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- Pharmacology For Benazepril
BenazeprilAbout BenazeprilAngiotensin - converting enzyme inhibitor (ACE - inhibitor), Anti hypertensive.Mechanism of Action of BenazeprilIt is a prodrug and converted in to active Benazeprilat; which is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.Pharmacokinets of BenazeprilAbsorption: Absorbed orally about 40%, Distribution: It is distributed in to the body, in a protein bound form, Metabolism: Metabolized in the body in to active metabolite, Benazeprilat and to the glucuronide conjugates of both drug and active metabolite. Excretion: Excreted mainly through urine.Onset of Action for BenazeprilN/ADuration of Action for Benazepril24 hourHalf Life of Benazepril10 to 12hoursSide Effects of Benazepril1.Cough
9.Swelling of lips, mouth, nose, and larynx
10.Fetopathic in later half of pregnancy
23.Urinary tract infections
25.Elevated liver enzymes
26.Altered kidney function tests
Contra-indications of Benazepril1.Hypersensitivity to the drug
2.Renal artery stenosis
4.Coarctation of aorta
Special Precautions while taking Benazepril1.Renal impairment
3.Ischaemic heart disease
4.Severe heart failure
5.Collagen vascular diseases
8.Use cautiously in volume depleted and salt depleted patients
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationContraindicated.Indications for BenazeprilHypertension.Interactions for BenazeprilDiuretics: May experience excessive BP reduction when benazepril is used. Benazepril may attenuate the potassium loss caused by thiazide diuretics which could be beneficial.
Potassium sparing diuretics and K-supplements: Can increase the risk of hyperkalemia.Typical Dosage for BenazeprilStarts with 10mg; orally once daily or in two divided doses. Increases the dose to the usual dosage of 20 to 40mg one or two divided doses; depending on patient`s response.Schedule of BenazeprilHStorage Requirements for BenazeprilStore at a temperature range of 15 to 30 degree C. in a well closed container and protect from light and moisture.Effects of Missed Dosage of BenazeprilTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BenazeprilTreatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases dialysis is considered if required. Treatment includes I.V. infusion of normal saline solution to treat hypotension. Treat dehydration and maintain electrolyte balance.
Home Delivery for Benazepril in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including benazepril.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for benazepril and other medicines and health products. Home delivery services for benazepril may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take benazepril only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for benazepril before they complete the sale. You can get this information while placing the order for benazepril with the pharmacy.
Benazepril is a generic medicine name and there are several brands available for it. Some of the brands for benazepril might be better known than benazepril itself. If the pharmacy that's willing to deliver medicines to your home doesn't have benazepril in stock, you can ask for one of the branded alternatives for benazepril.