Fosinopril Pharmacology


About Fosinopril
Phosphonate-containing Angiotensin-Converting Enzyme (ACE) Inhibitor, Antihypertensive.
Mechanism of Action of Fosinopril
It is a prodrug and converted in to active Fosinoprilat; which is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.
Pharmacokinets of Fosinopril
Absorption: Slowly absorbed orally about 36%
Distribution: It is distributed in to the body, in a protein bound form
Metabolism: Metabolized in the body in to active metabolite, Fosinoprilat in liver and intestinal wall.
Excretion: Excreted through urine and faeces.
Onset of Action for Fosinopril
60 minutes
Duration of Action for Fosinopril
24 hours
Half Life of Fosinopril
12 hours
Side Effects of Fosinopril
1. Cough
2. Angioedema
3. Chest pain
4. Hypotension
5. Hypertensive crisis
6. Memory disturbance
7. Arrhythmia
8. Tremor
9. Flushing
10. Hyperkalemia
11. Rashes
12. Urticaria
13. Swelling of lips mouth nose and larynx
14. Fetopathic in later half of pregnancy
15. Headache
16. Dizziness
17. Paraesthesia
18. Sleep disturbances
19. Nausea
20. Vomiting
21. Constipation
22. Abdominal pain
23. Dysphagia
24. Musculoskeletal pain
25. Infections
26. Altered liver and kidney function tests
27. Sexual dysfunction.

Contra-indications of Fosinopril
1. Hypersensitivity to the drug
2. Renal artery stenosis
3. Aortic stenosis
4. Coarctation of aorta
5. Angioedema
Special Precautions while taking Fosinopril
1. Renal impairment
2. Hepatic impairment
3. Patient of ischaemic heart disease
4. Severe heart failure
5. Collagen vascular diseases
6. Angioedema
7. Cerebrovascular diseases etc.
8. Use cautiously in volume depleted and salt depleted patients
9. Monitor WBC count during therapy and use with caution along with drugs which alter WBC count
10. Stops diuretics before starting therapy.

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Fosinopril
1. Hypertension,
2. Congestive heart failure
Interactions for Fosinopril
Diuretics : To decrease symptomatic hypertension with the initial dose, discontinue diuretic therapy before starting fosinopril.
Typical Dosage for Fosinopril
Starts with 10mg; orally once daily or in two divided doses. Increases the dose at one month interval to the usual dosage of 20 to 40mg one or two divided doses; depending on patient`s response.
Maximum dose: 80mg/day
Schedule of Fosinopril
Storage Requirements for Fosinopril
Store at a temperature range of 15 to 30 degree C. in a well closed container and protect from light and moisture.
Effects of Missed Dosage of Fosinopril
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Fosinopril
Treatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. Treatment includes I.V. infusion of normal saline solution to treat hypotension. Treat dehydration and maintain electrolyte balance

Home Delivery for Fosinopril in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fosinopril.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fosinopril and other medicines and health products. Home delivery services for fosinopril may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take fosinopril only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fosinopril before they complete the sale. You can get this information while placing the order for fosinopril with the pharmacy.

Fosinopril is a generic medicine name and there are several brands available for it. Some of the brands for fosinopril might be better known than fosinopril itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fosinopril in stock, you can ask for one of the branded alternatives for fosinopril.