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Benazepril + Amlodipine Pharmacology
Benazepril + AmlodipineAbout Benazepril + AmlodipineN/AMechanism of Action of Benazepril + AmlodipineN/APharmacokinets of Benazepril + AmlodipineN/AOnset of Action for Benazepril + AmlodipineN/ADuration of Action for Benazepril + AmlodipineN/AHalf Life of Benazepril + AmlodipineN/ASide Effects of Benazepril + AmlodipineN/AContra-indications of Benazepril + AmlodipineN/ASpecial Precautions while taking Benazepril + AmlodipineN/APregnancy Related InformationContraindicated; Benazepril and Amlodipine are contraindicated in pregnancy so the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Benazepril + AmlodipineIt is a combination of calcium channel blocker Amlodipine and ACE inhibitor Benazepril.
Interactions for Benazepril + AmlodipineN/ATypical Dosage for Benazepril + AmlodipineAdult:1 tablet / daySchedule of Benazepril + AmlodipineN/AStorage Requirements for Benazepril + AmlodipineN/AEffects of Missed Dosage of Benazepril + AmlodipineN/AEffects of Overdose of Benazepril + AmlodipineN/A
BenazeprilAbout BenazeprilAngiotensin - converting enzyme inhibitor (ACE - inhibitor), Anti hypertensive.Mechanism of Action of BenazeprilIt is a prodrug and converted in to active Benazeprilat; which is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.Pharmacokinets of BenazeprilAbsorption: Absorbed orally about 40%, Distribution: It is distributed in to the body, in a protein bound form, Metabolism: Metabolized in the body in to active metabolite, Benazeprilat and to the glucuronide conjugates of both drug and active metabolite. Excretion: Excreted mainly through urine.Onset of Action for BenazeprilN/ADuration of Action for Benazepril24 hourHalf Life of Benazepril10 to 12hoursSide Effects of Benazepril1.Cough
9.Swelling of lips, mouth, nose, and larynx
10.Fetopathic in later half of pregnancy
23.Urinary tract infections
25.Elevated liver enzymes
26.Altered kidney function tests
Contra-indications of Benazepril1.Hypersensitivity to the drug
2.Renal artery stenosis
4.Coarctation of aorta
Special Precautions while taking Benazepril1.Renal impairment
3.Ischaemic heart disease
4.Severe heart failure
5.Collagen vascular diseases
8.Use cautiously in volume depleted and salt depleted patients
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationContraindicated.Indications for BenazeprilHypertension.Interactions for BenazeprilDiuretics: May experience excessive BP reduction when benazepril is used. Benazepril may attenuate the potassium loss caused by thiazide diuretics which could be beneficial.
Potassium sparing diuretics and K-supplements: Can increase the risk of hyperkalemia.Typical Dosage for BenazeprilStarts with 10mg; orally once daily or in two divided doses. Increases the dose to the usual dosage of 20 to 40mg one or two divided doses; depending on patient`s response.Schedule of BenazeprilHStorage Requirements for BenazeprilStore at a temperature range of 15 to 30 degree C. in a well closed container and protect from light and moisture.Effects of Missed Dosage of BenazeprilTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BenazeprilTreatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases dialysis is considered if required. Treatment includes I.V. infusion of normal saline solution to treat hypotension. Treat dehydration and maintain electrolyte balance.
AmlodipineAbout AmlodipineCalcium Channel Blocker, Anti hypertensive,anti angina.Mechanism of Action of AmlodipineAmlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.Pharmacokinets of AmlodipineAbsorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.Onset of Action for AmlodipineSlowDuration of Action for Amlodipine24 hoursHalf Life of AmlodipineN/ASide Effects of Amlodipine1.Palpitation
12.Aggravates myocardial ischaemia
Contra-indications of Amlodipine1.Heart failure
3.Hypersensitivity to the drug
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution.Children Related InformationContraindicatedIndications for Amlodipine1.Hypertension
3.Stable anginaInteractions for AmlodipineACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.Typical Dosage for Amlodipine5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
.Schedule of AmlodipineHStorage Requirements for AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmlodipineMonitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.
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