Losartan Potassium Pharmacology

Losartan Potassium

About Losartan Potassium
An angiotensin II receptor antagonist, Antihypertensive.
Mechanism of Action of Losartan Potassium
It is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.
Pharmacokinets of Losartan Potassium
Absorption: Well absorbed orally, but bioavailability is about 33% due to first pass metabolism.
Distribution: Distributed in to the body in a protein bound form, but there is no brain penetration.
Metabolism: Metabolized in the liver in to active carboxylic acid metabolite and other metabolites.
Excretion: Excreted through faeces and urine.
Onset of Action for Losartan Potassium
1 hour
Duration of Action for Losartan Potassium
Half Life of Losartan Potassium
2 hours
Half life of active metabolite: 6 to 9 hours
Side Effects of Losartan Potassium
1. Hypotension
2. Hyperkalemia
3. Headache
4. Breathlessness
5. Chest pain
6. Sore throat
7. Infections
8. Weakness
9. Dizziness
10. Elevated liver enzyme levels
11. Myalgia
12. Fetopathic
13. Precipitate renal failure in renal artery stenosis, and in insufficient renal blood flow
14. Rashes
15. Insomnia
16. Nightmares
Contra-indications of Losartan Potassium
1. Hypersensitivity to the drug
Special Precautions while taking Losartan Potassium
1.Hepatic impairment
2.Renal impairment
3.Heart failure
4.Volume depleted individuals
5.Monitor serum potassium levels and avoid use along with potassium sparing diuretics
6. Avoid driving or operating heavy machinery during therapy
7. Avoid alcohol use during therapy
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Losartan Potassium
1. Hypertension
Interactions for Losartan Potassium
Diuretics, other antihypertensives: Potentiate the hypotensive effect of losartan.
Potassium sparing diuretics, potassium suppliments: Risk of hyperkalaemia.
NSAIDs: May blunt hypotensive effect of losartan.
Cytochrome P450 inhibitors like ketoconazole: Increase in AUC of losartan by 18 % but has no effect on its active metabolite.
Phenobarbital: Results in 20% reduction in AUC of losartan and its active metabolite.
Typical Dosage for Losartan Potassium
25 to 50mg once daily. Gradually increases up to 100mg once daily or as two divided doses.
Schedule of Losartan Potassium
Storage Requirements for Losartan Potassium
Store at room temperature at a range of 15 to 30 degree C. protect from moisture and store in a tightly closed container.
Effects of Missed Dosage of Losartan Potassium
Take the missed dose as soon as remember; if it is the time of next dose then skip the missed dose and take the regular dose.
Effects of Overdose of Losartan Potassium
Treatment is supportive and symptomatic.

Home Delivery for Losartan Potassium in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for losartan potassium and other medicines and health products. Home delivery services for losartan potassium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take losartan potassium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for losartan potassium before they complete the sale. You can get this information while placing the order for losartan potassium with the pharmacy.

Losartan Potassium is a generic medicine name and there are several brands available for it. Some of the brands for losartan potassium might be better known than losartan potassium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have losartan potassium in stock, you can ask for one of the branded alternatives for losartan potassium.