Candesartan Pharmacology


About Candesartan
Angiotensin II Receptor Antagonist, Antihypertensive agents.
Mechanism of Action of Candesartan
It is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.
Pharmacokinets of Candesartan
Absorption: Rapidly and compleately absorbed orally, Distribution: Widely distributed in to the body in a protein bound form, Metabolism: Undergoes minor hepatic metabolism by ortho-deethylation to an inactive metabolite. Excretion: Excreted through faeces and urine.
Onset of Action for Candesartan
Within 3 to 4hours
Duration of Action for Candesartan
24 hours
Half Life of Candesartan
8 to 12hours
Side Effects of Candesartan
2.Swelling of lips face tongue
6.Chest pain
10.Abdominal pain
15.Upper respiratory tract infections
19.Precipitate renal failure in renal artery stenosis and in insufficient renal blood flow
Contra-indications of Candesartan
Hypersensitivity to the drug.
Special Precautions while taking Candesartan
1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Aortic or mitral valve stenosis
5.Obstructive cardiomyopathy
6.Volume depleted and salt depleted individuals
7.Patient should be cautiously involve in driving or operating heavy machinery during therapy,
8.Avoid alcohol
10.Use caution while taking potassium sparing diuretics
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Candesartan
Interactions for Candesartan
No significant drug interactions have been reported when candesartan cilexetil is given with other drugs such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothazide and oral contraceptives in healthy volunteers.
Typical Dosage for Candesartan
Starts with 16mg once daily. Usual dose range is 8 to32mg/day as once daily or two divided doses.
Schedule of Candesartan
Storage Requirements for Candesartan
Store at room temperature at a range of 15 to 30 degree C. protects from direct heat and light and store in a tightly closed container.
Effects of Missed Dosage of Candesartan
Take the missed dose as soon as remember; If it is the time of next dose then skip the missed dose and take the regular dose
Effects of Overdose of Candesartan
Treatment is supportive and symptomatic. If hypotension occur kept patient in supine position and if required give I.V. infusion of normal saline.

Home Delivery for Candesartan in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including candesartan.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for candesartan and other medicines and health products. Home delivery services for candesartan may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take candesartan only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for candesartan before they complete the sale. You can get this information while placing the order for candesartan with the pharmacy.

Candesartan is a generic medicine name and there are several brands available for it. Some of the brands for candesartan might be better known than candesartan itself. If the pharmacy that's willing to deliver medicines to your home doesn't have candesartan in stock, you can ask for one of the branded alternatives for candesartan.