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- Pharmacology For Valsartan + S-Amlodipine
Valsartan + S-Amlodipine Pharmacology
Valsartan + S-AmlodipineAbout Valsartan + S-AmlodipineN/AMechanism of Action of Valsartan + S-AmlodipineN/APharmacokinets of Valsartan + S-AmlodipineN/AOnset of Action for Valsartan + S-AmlodipineN/ADuration of Action for Valsartan + S-AmlodipineN/AHalf Life of Valsartan + S-AmlodipineN/ASide Effects of Valsartan + S-AmlodipineN/AContra-indications of Valsartan + S-AmlodipineN/ASpecial Precautions while taking Valsartan + S-AmlodipineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Valsartan + S-AmlodipineN/AInteractions for Valsartan + S-AmlodipineN/ATypical Dosage for Valsartan + S-AmlodipineN/ASchedule of Valsartan + S-AmlodipineN/AStorage Requirements for Valsartan + S-AmlodipineN/AEffects of Missed Dosage of Valsartan + S-AmlodipineN/AEffects of Overdose of Valsartan + S-AmlodipineN/A
ValsartanAbout ValsartanAngiotensin II receptor antagonist, Antihypertensive.Mechanism of Action of ValsartanIt is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.Pharmacokinets of ValsartanAbsorption: Absorbed orally, bioavailability is about 25%.
Distribution: It is distributed in to the body in a protein bound form.
Metabolism: About 20% of the drug undergoes metabolism.
Excretion: Excreted mainly through faeces and rest is excreted through urine.
Onset of Action for Valsartan2 hoursDuration of Action for Valsartan24 hoursHalf Life of Valsartan6 hoursSide Effects of Valsartan1. Dizziness
6. Abdominal pain
11. Upper respiratory tract infections
16. Precipitate renal failure in renal artery stenosis and in insufficient renal blood flow
Contra-indications of Valsartan1. Hypersensitivity to the drugSpecial Precautions while taking Valsartan1.Renal impairment: Use with caution in renal impairment. Precipitate renal failure in renal artery stenosis, and in insufficient renal blood flow.
2.Hepatic impairment: Use with caution in hepatic impairment and dosage adjustment is required.
4.Aortic or mitral valve stenosis
6. Use cautiously in volume depleted and salt depleted individuals
7. Patient should be cautiously involve in driving or operating heavy machinery during therapy
8. Avoid alcohol or use with caution during therapy
9. Use with caution in hyperkalemia and along with potassium sparing diuretics
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Valsartan1. HypertensionInteractions for ValsartanPotassium-sparing diuretics (e.g., Spironolactone, Triamterene, Amiloride), Potassium supplements, or Salt substitutes containing potassium: Concomitant use of Valsartan with these drugs will result in hyperkalaemia and in heart failure patients it increases serum creatinine. Typical Dosage for ValsartanStarts with 80mg once daily. Increase the dosage after 2 to 4 weeks intervals depending upon the patient`s response to 160mg once daily or two divided doses or a diuretic should be added if required. Further increase in dosage is depending up on patient`s response.
Maximum dose: 320mg/day.
Schedule of ValsartanHStorage Requirements for ValsartanStore at room temperature at a range of 15 to 30 degree C. protects from direct heat and light and store in a tightly closed container.
Effects of Missed Dosage of ValsartanTake the missed dose as soon as remember; If it is the time of next dose then skip the missed dose and take the regular dose.
Effects of Overdose of ValsartanTreatment is supportive and symptomatic. If hypotension occur kept patient in supine position and if required give I.V. infusion of normal saline.
S-AmlodipineAbout S-AmlodipineCalcium Channel Blocker (dihydropyridine class), Anti hypertensive,anti angina.Mechanism of Action of S-AmlodipineS-Amlodipine, which is an enantiomer of Amlodipine; is a dihydropyridine Ca2+ channel blocker. It exerts it`s antihypertensive action through blocking the influx of Ca2+ ions through voltage gated L-type Calcium channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells and causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand and improves oxygen supply to myocardial cells. It directly dilates vascular smooth muscle and reduces hypertension.Pharmacokinets of S-AmlodipineN/AOnset of Action for S-AmlodipineN/ADuration of Action for S-AmlodipineN/AHalf Life of S-AmlodipineN/ASide Effects of S-Amlodipine1.Headache
Contra-indications of S-Amlodipine1.Hyper sensitivity to the drug or other dihydropyridines
Special Precautions while taking S-AmlodipineHepatic impairmentPregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for S-AmlodipineHypertensionInteractions for S-AmlodipineN/ATypical Dosage for S-Amlodipine2.5mg once dailySchedule of S-AmlodipineHStorage Requirements for S-AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.Effects of Missed Dosage of S-AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of S-AmlodipineGive supportive measures and symptomatic treatment.
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