Reserpine Pharmacology


About Reserpine
Central Monoamine-Depleting Agent, Rauwolfia Alkaloid, Antihypertensive , antipsychotic.
Mechanism of Action of Reserpine
The drug exerts its action by causing depletion of Catecholamine and serotonin which leads to decrease in blood pressure & bradycardia. Reserpine acts at the intraneural granular membrane which stores monoamines like Adrenaline, nor adrenaline, Serotonin, & Dopamine and irreversibly inhibits the active amine transport & storage. The mono amines are gradually depleted and degraded by MAO. It also inhibits the release of renin.Hypotensive action is primarily due to depletion of nor adrenaline from peripheral neurons.
Pharmacokinets of Reserpine
Absorption: well absorbed orally and parenterally, Distribution: Widely distributed preferably in to lipid rich tissues Metabolism: Metabolized inside the body
Onset of Action for Reserpine
Few days
Duration of Action for Reserpine
Half Life of Reserpine
Side Effects of Reserpine
1.Excessive salivation
2.Nasal congestion
3.Cutaneous vasodilatation
4.Increased gut motility
5.Increased acidity
6.A-V conduction blocks
7.Orthostatic hypotension
8.Mental depression
9.Exacerbate epilepsy
10.Weight gain
11.Electrolyte imbalance

Contra-indications of Reserpine
2.In patients receiving electro convulsive therapy
3.Peptic ulcer
4.Ulcerative colitis

Special Precautions while taking Reserpine
2.Myocardial infarction
5.Cardiac failure
6.Renal impairment
7.Hepatic impairment

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Reserpine
Interactions for Reserpine
Antihypertensives / Diuretics: Antihypertensive effects are enhanced.
Digitialis and Quinidine: May result in cardiac arrhythmias.
Ephedrine or Mephentermine: Hypertension may occur.
General anaesthesia: Hypotension and bradycardia may occur.
Levodopa: Signs and symptoms of Parkinsonism may be exacerbated.
MAOIs: Should be avoided since it may result in hypertension.
Sympathomimetics: Reserpine prolongs sympathomimetic response of direct acting and inhibits of indirect acting sympathomimetics.
TCAs: Results in a response refractory to TCA therapy. Also hypotension, flushing, diarrhoea and manic reactions may occur.
Lab tests: Increased serum prolactin levels, decreased urinary excretion of catecholamines, 17-ketosteroids, 17-hydroxycorticosteroids (17-OCHS) and vanillyl mandelic acid (VMA).
Typical Dosage for Reserpine
250 to 500mcg/day, gradually reduce to maintenance dose of 250mcg/day
Maximum dose: 1mg to 1.5 mg
Schedule of Reserpine
Storage Requirements for Reserpine
Store in a well closed container and protect from light. Keep out of the reach of children.
Effects of Missed Dosage of Reserpine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Reserpine
Treatment is supportive & symptomatic.

Home Delivery for Reserpine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including reserpine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for reserpine and other medicines and health products. Home delivery services for reserpine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take reserpine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for reserpine before they complete the sale. You can get this information while placing the order for reserpine with the pharmacy.

Reserpine is a generic medicine name and there are several brands available for it. Some of the brands for reserpine might be better known than reserpine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have reserpine in stock, you can ask for one of the branded alternatives for reserpine.