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- Pharmacology For Reserpine + Dihydralazine sulphate
Reserpine + Dihydralazine sulphate Pharmacology
Reserpine + Dihydralazine sulphateAbout Reserpine + Dihydralazine sulphateN/AMechanism of Action of Reserpine + Dihydralazine sulphateN/APharmacokinets of Reserpine + Dihydralazine sulphateN/AOnset of Action for Reserpine + Dihydralazine sulphateN/ADuration of Action for Reserpine + Dihydralazine sulphateN/AHalf Life of Reserpine + Dihydralazine sulphateN/ASide Effects of Reserpine + Dihydralazine sulphateN/AContra-indications of Reserpine + Dihydralazine sulphateN/ASpecial Precautions while taking Reserpine + Dihydralazine sulphateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Reserpine + Dihydralazine sulphateN/AInteractions for Reserpine + Dihydralazine sulphateN/ATypical Dosage for Reserpine + Dihydralazine sulphateN/ASchedule of Reserpine + Dihydralazine sulphateN/AStorage Requirements for Reserpine + Dihydralazine sulphateN/AEffects of Missed Dosage of Reserpine + Dihydralazine sulphateN/AEffects of Overdose of Reserpine + Dihydralazine sulphateN/A
ReserpineAbout ReserpineCentral Monoamine-Depleting Agent, Rauwolfia Alkaloid, Antihypertensive , antipsychotic.Mechanism of Action of ReserpineThe drug exerts its action by causing depletion of Catecholamine and serotonin which leads to decrease in blood pressure & bradycardia. Reserpine acts at the intraneural granular membrane which stores monoamines like Adrenaline, nor adrenaline, Serotonin, & Dopamine and irreversibly inhibits the active amine transport & storage. The mono amines are gradually depleted and degraded by MAO. It also inhibits the release of renin.Hypotensive action is primarily due to depletion of nor adrenaline from peripheral neurons.Pharmacokinets of ReserpineAbsorption: well absorbed orally and parenterally, Distribution: Widely distributed preferably in to lipid rich tissues Metabolism: Metabolized inside the bodyOnset of Action for ReserpineFew daysDuration of Action for ReserpineN/AHalf Life of ReserpineN/ASide Effects of Reserpine1.Excessive salivation
4.Increased gut motility
6.A-V conduction blocks
Contra-indications of Reserpine1.Depression
2.In patients receiving electro convulsive therapy
Special Precautions while taking Reserpine1.Tachycardia
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for ReserpineHypertensionInteractions for ReserpineAntihypertensives / Diuretics: Antihypertensive effects are enhanced.
Digitialis and Quinidine: May result in cardiac arrhythmias.
Ephedrine or Mephentermine: Hypertension may occur.
General anaesthesia: Hypotension and bradycardia may occur.
Levodopa: Signs and symptoms of Parkinsonism may be exacerbated.
MAOIs: Should be avoided since it may result in hypertension.
Sympathomimetics: Reserpine prolongs sympathomimetic response of direct acting and inhibits of indirect acting sympathomimetics.
TCAs: Results in a response refractory to TCA therapy. Also hypotension, flushing, diarrhoea and manic reactions may occur.
Lab tests: Increased serum prolactin levels, decreased urinary excretion of catecholamines, 17-ketosteroids, 17-hydroxycorticosteroids (17-OCHS) and vanillyl mandelic acid (VMA).Typical Dosage for Reserpine250 to 500mcg/day, gradually reduce to maintenance dose of 250mcg/day
Maximum dose: 1mg to 1.5 mg
Schedule of ReserpineHStorage Requirements for ReserpineStore in a well closed container and protect from light. Keep out of the reach of children.Effects of Missed Dosage of ReserpineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of ReserpineTreatment is supportive & symptomatic.
Dihydralazine sulphateAbout Dihydralazine sulphateA pyridazine antiadrenergic agent, Nonsympatholytic vasodilatory antihypertensives.Mechanism of Action of Dihydralazine sulphateDihydralazine is an antihypertensive and its actions are similar to Hydralazine.Hydralazine exerts its pharmacological actions by direct vasodilator action on arteriolar smooth muscles with little actions on venous capacitance vessels. It produces after load reduction by dilating resistance vessels which leads to decreasing aortic impedence.So that more blood is pumped even in weaker ventricular contractions. It decreases total peripheral resistance and there is greater decrease in diastolic pressure than systolic pressure. There is a decrease in intracellular Ca2+concentration but there is no reduction in renal blood flow.Pharmacokinets of Dihydralazine sulphateAbsorption: It is well absorbed orally, but bioavailability is low in fast acetylators.Distribution: Widely distributed in a highly plasma protein bound form.Metabolism: It is metabolized in liver,plasma and gastrointestinal mucosa. Excretion: Excreted mainly through urine and the rest of dose is excreted through bile and faeces.
Onset of Action for Dihydralazine sulphateN/ADuration of Action for Dihydralazine sulphateN/AHalf Life of Dihydralazine sulphateN/ASide Effects of Dihydralazine sulphate1. Tachycardia
6. Dryness of mouth
7. Nasal congestion
11. Orthostatic hypotension
14. Sleep disturbances
15. Reversible lupus erythmatosis
18. Muscle cramps
Contra-indications of Dihydralazine sulphate1. Hypersensitivity to the drug
2. Ischaemic heart disease
3. Coronary artery diseases
4. Valvular stenosis
6. Aortic aneurism
Special Precautions while taking Dihydralazine sulphate1. Renal impairment
2. Hepatic impairment
3. Cardiovascular disorders
4. Cerebro vascular disorders
5. Use with caution along with other antihypertensive drugs
6. Slowly withdraw the drug with caution
Pregnancy Related InformationUse with cautionOld Age Related InformationContraindicatedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Dihydralazine sulphate1. Hypertension
2. Congestive heart failure
Interactions for Dihydralazine sulphateN/ATypical Dosage for Dihydralazine sulphateAs directed by the physicianSchedule of Dihydralazine sulphateHStorage Requirements for Dihydralazine sulphateStore at controlled room temperature at a temperature range of 15 to 30 degree C in a light resistant tightly closed container.Effects of Missed Dosage of Dihydralazine sulphateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of Dihydralazine sulphateTreatment is supportive and symptomatic. After ingestion empty the stomach by induced emesis and gastric lavage. Administer activated charcoal to reduce absorption.
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