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- Generic Medicines
- Pharmacology For Nicorandil
NicorandilAbout NicorandilA potassium channel opener,a vasodilator, Antianginal.Mechanism of Action of NicorandilThe drug exerts antianginal action by activating ATP sensitive potassium channels which leads to hyperpolarizing vascular smooth muscle and ultimate vasodilatation. It also acts as a nitric oxide donor relaxes blood vessels by increasing cyclic GMP and hence arterial dilatation is coupled with venodilatation. Dilatations of both epicardial conducting vessels and deeper resistance vessels have occurred and coronary flow is increased. Improves exercise tolerance and reduce frequency of angina. Mitochondrial K+ATP channel opening by Nicorandil also exerts myocardial protection by a process of ischaemic preconditioning which reduce myocardial stunning, arrhythmias and infarct size when a coronary artery is suddenly blocked. Myocardial recovery from ischaemic damage after myocardial infarction as measured by left ventricular wall motion is improved by Nicorandil.Pharmacokinets of NicorandilAbsorption: Well absorbed orally, Metabolism: Entirely metabolized in liver. Excretion: Excreted as metabolites in urine.Onset of Action for NicorandilN/ADuration of Action for Nicorandil12 hoursHalf Life of NicorandilN/ASide Effects of Nicorandil1. Headache
Contra-indications of Nicorandil1. Hypersensitivity to the drug
3. Cardiogenic Shock
4. Left ventricular failure
5. Along with phosphodiesterase-5 inhibitors
Special Precautions while taking Nicorandil1.Blood volume depletetion
2.Low systolic blood pressure
3.Acute pulmonary edema
5.Along with other anti hypertensive drugs
6.Alternative therapy should be considered in Mouth ulceration and persistent aphtosisPregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Nicorandil1.Stable angina
3.Congestive heart diseases
Interactions for NicorandilAtenolol: Antihypertensive effects potentiated while the reflex tachycardia is obviated.Typical Dosage for Nicorandil10 to 40mg/day in two divided doses
Maximum doe: 60mg/day in two divided doses.
Schedule of NicorandilN/AStorage Requirements for NicorandilStore in a dry place in a tightly closed container below 25 degree C.Effects of Missed Dosage of NicorandilTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NicorandilTreatment is supportive and symptomatic. Monitor and assist cardiac function. Infuse plasma volume expanders if required. Administer vasopressors in life threatening conditions.
Home Delivery for Nicorandil in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nicorandil.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nicorandil and other medicines and health products. Home delivery services for nicorandil may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take nicorandil only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nicorandil before they complete the sale. You can get this information while placing the order for nicorandil with the pharmacy.
Nicorandil is a generic medicine name and there are several brands available for it. Some of the brands for nicorandil might be better known than nicorandil itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nicorandil in stock, you can ask for one of the branded alternatives for nicorandil.