Nicorandil Pharmacology


About Nicorandil
A potassium channel opener,a vasodilator, Antianginal.
Mechanism of Action of Nicorandil
The drug exerts antianginal action by activating ATP sensitive potassium channels which leads to hyperpolarizing vascular smooth muscle and ultimate vasodilatation. It also acts as a nitric oxide donor relaxes blood vessels by increasing cyclic GMP and hence arterial dilatation is coupled with venodilatation. Dilatations of both epicardial conducting vessels and deeper resistance vessels have occurred and coronary flow is increased. Improves exercise tolerance and reduce frequency of angina. Mitochondrial K+ATP channel opening by Nicorandil also exerts myocardial protection by a process of ischaemic preconditioning which reduce myocardial stunning, arrhythmias and infarct size when a coronary artery is suddenly blocked. Myocardial recovery from ischaemic damage after myocardial infarction as measured by left ventricular wall motion is improved by Nicorandil.
Pharmacokinets of Nicorandil
Absorption: Well absorbed orally, Metabolism: Entirely metabolized in liver. Excretion: Excreted as metabolites in urine.
Onset of Action for Nicorandil
Duration of Action for Nicorandil
12 hours
Half Life of Nicorandil
Side Effects of Nicorandil
1. Headache
7.Mouth ulcers
10.Gastrointestinal disturbances
Contra-indications of Nicorandil
1. Hypersensitivity to the drug
2. Hypotension
3. Cardiogenic Shock
4. Left ventricular failure
5. Along with phosphodiesterase-5 inhibitors

Special Precautions while taking Nicorandil
1.Blood volume depletetion
2.Low systolic blood pressure
3.Acute pulmonary edema
4.Myocardial infarction
5.Along with other anti hypertensive drugs
6.Alternative therapy should be considered in Mouth ulceration and persistent aphtosis
Pregnancy Related Information
Old Age Related Information
May be used
Breast Feeding Related Information
Children Related Information
Indications for Nicorandil
1.Stable angina
2.Vasospastic angina
3.Congestive heart diseases
Interactions for Nicorandil
Atenolol: Antihypertensive effects potentiated while the reflex tachycardia is obviated.
Typical Dosage for Nicorandil
10 to 40mg/day in two divided doses
Maximum doe: 60mg/day in two divided doses.
Schedule of Nicorandil
Storage Requirements for Nicorandil
Store in a dry place in a tightly closed container below 25 degree C.
Effects of Missed Dosage of Nicorandil
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Nicorandil
Treatment is supportive and symptomatic. Monitor and assist cardiac function. Infuse plasma volume expanders if required. Administer vasopressors in life threatening conditions.

Home Delivery for Nicorandil in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nicorandil.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nicorandil and other medicines and health products. Home delivery services for nicorandil may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nicorandil only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nicorandil before they complete the sale. You can get this information while placing the order for nicorandil with the pharmacy.

Nicorandil is a generic medicine name and there are several brands available for it. Some of the brands for nicorandil might be better known than nicorandil itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nicorandil in stock, you can ask for one of the branded alternatives for nicorandil.