Isoprenaline Pharmacology


About Isoprenaline
Adrenergic Beta1and Beta2 Agonist, Antiasthmatic , Cardiac stimulant.
Mechanism of Action of Isoprenaline
Isoprenaline exerts its pharmacological action by acting as a non selective beta adrenergic agonist. It causes bronchodilatation, cardiac stimulation, and peripheral vasodilatation. By its direct action on beta-2 adrenergic receptors it relaxes bronchial smooth muscles, relieving broncho-spasm, increasing vital capacity, decreasing residual volume in lungs, and facilitating passage of pulmonary secretions. It exerts cardiac stimulant action; by action on beta-1 adrenergic receptors and producing positive chronotropic and inotropic effects. It increases cardiac output. In AV block it shortens conduction time and refractory period of the AV block and increases rate and strength of ventricular contraction.
Pharmacokinets of Isoprenaline
Absorption: Rapidly absorbed after parenteral and administration and after oral inhalation.
Distribution: Widely distributed in the body.
Metabolism: Metabolized by conjugation in the gastrointestinal tract and enzymatic reduction in liver, lungs and other tissues.
Excretion: Excreted through urine as metabolites and as unchanged drugs.
Onset of Action for Isoprenaline
Duration of Action for Isoprenaline
Few minutes to 6 hours
Half Life of Isoprenaline
Side Effects of Isoprenaline
1. Rapid fluctuations in blood pressure
2. Tachycardia
3. Palpitations
4. Headache
5. Dizziness
6. Weakness
7. Nervousness
8. Restlessness
9. Tremor
10. Anginal pain
11. Stokes-Adams attack
12. Arrhythmias
13. Cardiac arrest
14. Diaphoresis
15. Insomnia
16. Heart burn

Contra-indications of Isoprenaline
1. Hypersensitivity to the drug
2. Tachycardia
3. Arrhythmias(except that respond to treatment with Isoprenaline)
4. Angina pectoris
5. Susceptibility to ventricular fibrillation
6. Acute coronary disease
7. Hyperthyroidism
8. Recent myocardial infarction

Special Precautions while taking Isoprenaline
1. Hypertension
2. Monitor blood pressure during therapy
3. Renal impairment
4. Coronary insufficiency
5. Ischaemic heart diseases
6. Hyperthyroidism
7. Diabetes
8. Sensitivity to sympathomimetic amines
9. AV node disease.

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Isoprenaline
1. Bradycardia
2. Bronchospasm
3. Heart block
4. Shock

Interactions for Isoprenaline
Typical Dosage for Isoprenaline
0.5 to 10mcg/minute as I.V. infusion. Titrate the dosage based on patient`s response.
Schedule of Isoprenaline
C & C1
Storage Requirements for Isoprenaline
Store at room temperature.
Effects of Missed Dosage of Isoprenaline
Take the missed dose as soon as remember and If it is the time for next dose then skip the missed dose and take the regular dose.
Effects of Overdose of Isoprenaline
Treatment is supportive and symptomatic. Closely monitor vital signs. Treat CNS stimulation with sedatives such as barbiturates. Treat tachycardia and arrhythmia with cardio selective beta blockers. Use these agents with caution because they may induce asthma attacks.

Home Delivery for Isoprenaline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including isoprenaline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for isoprenaline and other medicines and health products. Home delivery services for isoprenaline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take isoprenaline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for isoprenaline before they complete the sale. You can get this information while placing the order for isoprenaline with the pharmacy.

Isoprenaline is a generic medicine name and there are several brands available for it. Some of the brands for isoprenaline might be better known than isoprenaline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have isoprenaline in stock, you can ask for one of the branded alternatives for isoprenaline.