Ethamsylate Pharmacology


About Ethamsylate
Benzenesulfonate derivative, Systemic haemostatic.
Mechanism of Action of Ethamsylate
It exerts haemostatic action by acting on the first step of haemostasis by improving platelet adhesiveness and restoring capillary resistance. It decreases bleeding time and increases platelet aggregation. It reduces capillary bleeding when platelets are adequate. The drug exerts antihyaluronidase action and improves capillary wall stability. It inhibits PGI-2 synthesis and correct abnormal platelet function.
Pharmacokinets of Ethamsylate
Absorption: Well absorbed orally.
Distribution: Distributed in a protein bound form.
Excretion: Excreted through urine as unchanged drug.
Onset of Action for Ethamsylate
Duration of Action for Ethamsylate
3 days
Half Life of Ethamsylate
8 hours.
Side Effects of Ethamsylate
1. Headache
2. Nausea
3. Rash
4. Fall in BP(only after I.V. administration)

Contra-indications of Ethamsylate
1. Hypersensitivity to the drug
2. Porphyria
3. Haemophilia
4. Thrombocytopenic purpura

Special Precautions while taking Ethamsylate
Pregnancy Related Information
Old Age Related Information
May be used
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Ethamsylate
Used for prevention of haemorrhage in various conditions like :-
1. Menorrhagia
2. Metrorrhagia
3. After abortion
4. Post partum haemorrhage
5. Epistaxis
6. Melena
7. Haematuria
8. After tooth extraction
9. Surgical procedures
10. Haematemesis
11. Haemoptysis

Interactions for Ethamsylate
No known interaction.
Typical Dosage for Ethamsylate
250 mg twice daily to 500mg thrice daily until bleeding stops.
In menorrhagia and metrorrhagia: 250mg 8th hourly. Increases the dosage to 500mg 8th hourly if required depending up on the condition of the disease.
In persistent menorrhagia take 0.5g 8th hourly starting form 5days before menstruation and continued up to 5 days after menstruation.
Children: Half of adult dose.

250mg to 500mg I.V. or I.M.
Take 1 hour before the procedure during Preoperative indications, repeat the dosage if required during the surgery and in post operative indications take the same dose and repeat 4 to 6 times daily until bleeding stops. In emergency situations also repeat the dosage 4 to 6 times daily until bleeding stops.
Children: Half of adult dose.
Neonates: 10mg/kg intramuscularly within two hours after birth and repeat at 4 to 6 times daily until bleeding stops.

Schedule of Ethamsylate
Storage Requirements for Ethamsylate
Store in a cool dry place and protects from direct heat and light.
Effects of Missed Dosage of Ethamsylate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.
Effects of Overdose of Ethamsylate
Give supportive measures and symptomatic treatment.

Home Delivery for Ethamsylate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ethamsylate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ethamsylate and other medicines and health products. Home delivery services for ethamsylate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ethamsylate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ethamsylate before they complete the sale. You can get this information while placing the order for ethamsylate with the pharmacy.

Ethamsylate is a generic medicine name and there are several brands available for it. Some of the brands for ethamsylate might be better known than ethamsylate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ethamsylate in stock, you can ask for one of the branded alternatives for ethamsylate.