Aprotinin Pharmacology


About Aprotinin
Bovine pancreatic trypsin inhibitor(natural proteinase inhibitor), Hemostatic.
Mechanism of Action of Aprotinin
Aprotinin is a polypeptide obtained from bovine lung tissues with polyvalent protease inhibitory activity. It inhibits trypsin, chymotrypsin, kallikrein, and plasmin. It inhibits fibrinolysis and turnover of coagulation factors and prevents bleeding.
It inhibits serine proteases and preserves platelet function and decrease bleeding time. It inhibits contact face activation and preserves adhesive glycoprotein in the platelet membrane. It increases resistance to damage and preserves adhesive glycoprotein receptors in the platelets which are responsible for platelet adhesion to endothelium. It prevents expression of proinflamatory adhesive glycoprotein and inhibits proinflamatory cytokine release.
Pharmacokinets of Aprotinin
Absorption: Administered intravenously. Distribution: Distributed extracellularly and accumulates in kidneys. Metabolism: It is degraded by lysosomal enzymes in proximal tubules of kidneys. Excretion: Up to 40% is excreted in urine.

Onset of Action for Aprotinin
Duration of Action for Aprotinin
Half Life of Aprotinin
2 to 5hours
Side Effects of Aprotinin
1.Hypersensitivity reactions
2.Anaphylactic shock
3.Local thrombophlebitis
10.Skin eruptions
Contra-indications of Aprotinin
Hypersensitivity to the drug
Special Precautions while taking Aprotinin
1. First give a test dose 10 minutes prior to loading dose to access allergy to the drug.
2. If hypersensitivity reactions appear during loading dose administration stops the drug immediately.
Pregnancy Related Information
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Aprotinin
1.Cardio pulmonary bypass surgery
Interactions for Aprotinin
Fibrinolytic agents: May inhibit the effects of fibrinolytic agents.
Heparin: May prolong activated blood clotting time. Dosage may need to be adjusted.
Captopril: May block the hypotensive effect of captopril.
Typical Dosage for Aprotinin
Cardio pulmonary bypass surgery: 2000,000 KIU Aprotinin loading dose, immediately after anaesthetic induction 2000,000KIU added to cardiopulmonary bypass circuit prime, and a continuous infusion of 500000 KIU during surgery until closing chest.
Other wise low dose protocol is adopted which use half of full dose as effective as full dose except in anti inflammatory activity.
Haemorrhage: 500000 to 1000000 KIU by slow infusion at a rate of 100000KIU/minute. Followed by 200000KIU every hour until bleeding stops.

Schedule of Aprotinin
Storage Requirements for Aprotinin
Store at a temperature range of 2 to 8degree C.
Effects of Missed Dosage of Aprotinin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Aprotinin
Treatment is supportive and symptomatic

Home Delivery for Aprotinin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including aprotinin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for aprotinin and other medicines and health products. Home delivery services for aprotinin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take aprotinin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for aprotinin before they complete the sale. You can get this information while placing the order for aprotinin with the pharmacy.

Aprotinin is a generic medicine name and there are several brands available for it. Some of the brands for aprotinin might be better known than aprotinin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aprotinin in stock, you can ask for one of the branded alternatives for aprotinin.