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- Pharmacology For Ethamsylate + Mefenamic acid
Ethamsylate + Mefenamic acid Pharmacology
Ethamsylate + Mefenamic acidAbout Ethamsylate + Mefenamic acidN/AMechanism of Action of Ethamsylate + Mefenamic acidN/APharmacokinets of Ethamsylate + Mefenamic acidN/AOnset of Action for Ethamsylate + Mefenamic acidN/ADuration of Action for Ethamsylate + Mefenamic acidN/AHalf Life of Ethamsylate + Mefenamic acidN/ASide Effects of Ethamsylate + Mefenamic acidN/AContra-indications of Ethamsylate + Mefenamic acidN/ASpecial Precautions while taking Ethamsylate + Mefenamic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ethamsylate + Mefenamic acidN/AInteractions for Ethamsylate + Mefenamic acidN/ATypical Dosage for Ethamsylate + Mefenamic acidN/ASchedule of Ethamsylate + Mefenamic acidN/AStorage Requirements for Ethamsylate + Mefenamic acidN/AEffects of Missed Dosage of Ethamsylate + Mefenamic acidN/AEffects of Overdose of Ethamsylate + Mefenamic acidN/A
EthamsylateAbout EthamsylateBenzenesulfonate derivative, Systemic haemostatic.Mechanism of Action of EthamsylateIt exerts haemostatic action by acting on the first step of haemostasis by improving platelet adhesiveness and restoring capillary resistance. It decreases bleeding time and increases platelet aggregation. It reduces capillary bleeding when platelets are adequate. The drug exerts antihyaluronidase action and improves capillary wall stability. It inhibits PGI-2 synthesis and correct abnormal platelet function.Pharmacokinets of EthamsylateAbsorption: Well absorbed orally.
Distribution: Distributed in a protein bound form.
Excretion: Excreted through urine as unchanged drug.
Onset of Action for EthamsylateN/ADuration of Action for Ethamsylate3 daysHalf Life of Ethamsylate8 hours.Side Effects of Ethamsylate1. Headache
4. Fall in BP(only after I.V. administration)
Contra-indications of Ethamsylate1. Hypersensitivity to the drug
4. Thrombocytopenic purpura
Special Precautions while taking EthamsylateHPregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for EthamsylateUsed for prevention of haemorrhage in various conditions like :-
3. After abortion
4. Post partum haemorrhage
8. After tooth extraction
9. Surgical procedures
Interactions for EthamsylateNo known interaction.Typical Dosage for EthamsylateDosage:
250 mg twice daily to 500mg thrice daily until bleeding stops.
In menorrhagia and metrorrhagia: 250mg 8th hourly. Increases the dosage to 500mg 8th hourly if required depending up on the condition of the disease.
In persistent menorrhagia take 0.5g 8th hourly starting form 5days before menstruation and continued up to 5 days after menstruation.
Children: Half of adult dose.
250mg to 500mg I.V. or I.M.
Take 1 hour before the procedure during Preoperative indications, repeat the dosage if required during the surgery and in post operative indications take the same dose and repeat 4 to 6 times daily until bleeding stops. In emergency situations also repeat the dosage 4 to 6 times daily until bleeding stops.
Children: Half of adult dose.
Neonates: 10mg/kg intramuscularly within two hours after birth and repeat at 4 to 6 times daily until bleeding stops.
Schedule of EthamsylateHStorage Requirements for EthamsylateStore in a cool dry place and protects from direct heat and light.Effects of Missed Dosage of EthamsylateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Effects of Overdose of EthamsylateGive supportive measures and symptomatic treatment.
Mefenamic AcidAbout Mefenamic AcidNSAID, Analgesic,antiinflammatory.Mechanism of Action of Mefenamic AcidMefenamic acid has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other analgesics. Mefenamic acid inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.Pharmacokinets of Mefenamic AcidAbsorption: Mefenamic acid is well absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Mefenamic acid and its metabolites are excreted mainly in the urine.Onset of Action for Mefenamic Acid1-2 hours.Duration of Action for Mefenamic Acid6 hours.Half Life of Mefenamic Acid2-4 hours.Side Effects of Mefenamic Acid1.Nausea
Contra-indications of Mefenamic Acid1.Hypersensitivity to Mefenamic acid and other NSAIDs
2.Inflammatory bowel disease
Special Precautions while taking Mefenamic Acid1.Hepatic impairment
5.Pre existing asthma
6.Patient on anticoagulant therapy
9.StrokePregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationBelow 14 years: contraindicated
NEONATES: used only to close the patent ductus arteriosus as IV form only
Indications for Mefenamic Acid1.Muscular aches
6.Patent ductus arteriosus
Interactions for Mefenamic AcidN/ATypical Dosage for Mefenamic AcidAdult: initial dose: 500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children above 14 years:
500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children below 14 years: not recommended.
Schedule of Mefenamic AcidHStorage Requirements for Mefenamic AcidStore Mefenamic acid at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Mefenamic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Mefenamic AcidGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.
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