- Medicine India
- Generic Medicines
- E
- Pharmacology For Ethamsylate + Tranexamic acid
Ethamsylate + Tranexamic acid Pharmacology
Ethamsylate + Tranexamic acid
About Ethamsylate + Tranexamic acidN/AMechanism of Action of Ethamsylate + Tranexamic acidN/APharmacokinets of Ethamsylate + Tranexamic acidN/AOnset of Action for Ethamsylate + Tranexamic acidN/ADuration of Action for Ethamsylate + Tranexamic acidN/AHalf Life of Ethamsylate + Tranexamic acidN/ASide Effects of Ethamsylate + Tranexamic acidN/AContra-indications of Ethamsylate + Tranexamic acidN/ASpecial Precautions while taking Ethamsylate + Tranexamic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ethamsylate + Tranexamic acidN/AInteractions for Ethamsylate + Tranexamic acidN/ATypical Dosage for Ethamsylate + Tranexamic acidN/ASchedule of Ethamsylate + Tranexamic acidN/AStorage Requirements for Ethamsylate + Tranexamic acidN/AEffects of Missed Dosage of Ethamsylate + Tranexamic acidN/AEffects of Overdose of Ethamsylate + Tranexamic acidN/AEthamsylate
About EthamsylateBenzenesulfonate derivative, Systemic haemostatic.Mechanism of Action of EthamsylateIt exerts haemostatic action by acting on the first step of haemostasis by improving platelet adhesiveness and restoring capillary resistance. It decreases bleeding time and increases platelet aggregation. It reduces capillary bleeding when platelets are adequate. The drug exerts antihyaluronidase action and improves capillary wall stability. It inhibits PGI-2 synthesis and correct abnormal platelet function.Pharmacokinets of EthamsylateAbsorption: Well absorbed orally.
Distribution: Distributed in a protein bound form.
Excretion: Excreted through urine as unchanged drug.
Onset of Action for EthamsylateN/ADuration of Action for Ethamsylate3 daysHalf Life of Ethamsylate8 hours.Side Effects of Ethamsylate1. Headache
2. Nausea
3. Rash
4. Fall in BP(only after I.V. administration)
Contra-indications of Ethamsylate1. Hypersensitivity to the drug
2. Porphyria
3. Haemophilia
4. Thrombocytopenic purpura
Special Precautions while taking EthamsylateHPregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for EthamsylateUsed for prevention of haemorrhage in various conditions like :-
1. Menorrhagia
2. Metrorrhagia
3. After abortion
4. Post partum haemorrhage
5. Epistaxis
6. Melena
7. Haematuria
8. After tooth extraction
9. Surgical procedures
10. Haematemesis
11. Haemoptysis
Interactions for EthamsylateNo known interaction.Typical Dosage for EthamsylateDosage:
Oral:
250 mg twice daily to 500mg thrice daily until bleeding stops.
In menorrhagia and metrorrhagia: 250mg 8th hourly. Increases the dosage to 500mg 8th hourly if required depending up on the condition of the disease.
In persistent menorrhagia take 0.5g 8th hourly starting form 5days before menstruation and continued up to 5 days after menstruation.
Children: Half of adult dose.
Parenteral:
250mg to 500mg I.V. or I.M.
Take 1 hour before the procedure during Preoperative indications, repeat the dosage if required during the surgery and in post operative indications take the same dose and repeat 4 to 6 times daily until bleeding stops. In emergency situations also repeat the dosage 4 to 6 times daily until bleeding stops.
Children: Half of adult dose.
Neonates: 10mg/kg intramuscularly within two hours after birth and repeat at 4 to 6 times daily until bleeding stops.
Schedule of EthamsylateHStorage Requirements for EthamsylateStore in a cool dry place and protects from direct heat and light.Effects of Missed Dosage of EthamsylateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Effects of Overdose of EthamsylateGive supportive measures and symptomatic treatment.Tranexamic Acid
About Tranexamic AcidLysine Analog, Hemostatic, competitive plasminogen activationinhibitor, Antifibrinolytic,Antihemophilic.Mechanism of Action of Tranexamic AcidTranexamic acid exerts antifibrinolytic effect by forming a reversible complex with plasminogen through the lysine binding site of fibrin and thus displaces the plasminogen from the fibrin surface ; preventing the binding of plasmin to fibrinogen or fibrin monomers. It inhibits the activation of plasminogen (i.e. formation of plasmin). It also acts as a weak non competitive inhibitor of plasmin and blocks it`s action on fibrin.Pharmacokinets of Tranexamic AcidAbsorption: About 40% is absorbed orally. Distribution: Widely distributed in the body. Excretion: Excreted mainly as unchanged drug.Onset of Action for Tranexamic AcidN/ADuration of Action for Tranexamic AcidN/AHalf Life of Tranexamic Acid2 hoursSide Effects of Tranexamic Acid1.Nausea
2.Diarrhoea
3.Gastrointestinal problems
4.Headache
5.Hypotension
6.Giddiness
7.Thrombophlebitis at injected vein
8.Impairment of Colour vision
Contra-indications of Tranexamic Acid1.Thromboembolic disorders
2.Subarachnoid haemorrhage
3.Massive upper urinary tract haemorrhage
4.Colour vision disorders
5.Thrombophlebitis
6.Hepatic impairment
7.Severe renal impairment
Special Precautions while taking Tranexamic Acid1.Avoid rapid I.V. administration
2.Lower dosage adjustment is required in renal impairment
3.Monitor liver functioning during long term use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Tranexamic Acid1.Surgical procedures
2.Menorrhagia
3. Metrorrhagia
4.Post partum haemorrhage
5.Haemorrhage after abortion
6.Haemorrhage due to contraceptive device insertion
7.Tooth extractions and haemorrhage in other dental procedures
8.Epistaxis
9.Haemoptysis
10.Gastrointestinal bleeding
11.Prostatectomy
12.Tonsillectomy
13.Fibrinolysis
14.Ocular trauma
15.Orthopedic surgery
16.Cardiovascular surgery
Interactions for Tranexamic AcidN/ATypical Dosage for Tranexamic AcidOral: 3 to 4gm/day in 3 to 4 divided doses or 15 to 25mg/kg body wt. 3 to 4 times daily.
I.V.: 1.5 to 3gm/day in 3 divided doses or 10 to 15mg/kg body wt. 3 times daily. Administered as slow I.V. injection or as continuous infusion; at a rate of 25 to 50mg/kg/day.
Schedule of Tranexamic AcidN/AStorage Requirements for Tranexamic AcidStore below 25 degree C. and protects from light. Keep out of reach of children.
Effects of Missed Dosage of Tranexamic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Tranexamic AcidTreatment is supportive and symptomatic. Remove drug from the body by induced emesis, gastric lavage and administer activated charcoal to reduce absorption. Maintain adequate diuresis with the aid of fluids and diuretics.Home Delivery for Ethamsylate + Tranexamic acid in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ethamsylate + tranexamic acid.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ethamsylate + tranexamic acid and other medicines and health products. Home delivery services for ethamsylate + tranexamic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take ethamsylate + tranexamic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ethamsylate + tranexamic acid before they complete the sale. You can get this information while placing the order for ethamsylate + tranexamic acid with the pharmacy.
Ethamsylate + Tranexamic acid is a generic medicine name and there are several brands available for it. Some of the brands for ethamsylate + tranexamic acid might be better known than ethamsylate + tranexamic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ethamsylate + tranexamic acid in stock, you can ask for one of the branded alternatives for ethamsylate + tranexamic acid.
