Tranexamic Acid Pharmacology

Tranexamic Acid

About Tranexamic Acid
Lysine Analog, Hemostatic, competitive plasminogen activationinhibitor, Antifibrinolytic,Antihemophilic.
Mechanism of Action of Tranexamic Acid
Tranexamic acid exerts antifibrinolytic effect by forming a reversible complex with plasminogen through the lysine binding site of fibrin and thus displaces the plasminogen from the fibrin surface ; preventing the binding of plasmin to fibrinogen or fibrin monomers. It inhibits the activation of plasminogen (i.e. formation of plasmin). It also acts as a weak non competitive inhibitor of plasmin and blocks it`s action on fibrin.
Pharmacokinets of Tranexamic Acid
Absorption: About 40% is absorbed orally. Distribution: Widely distributed in the body. Excretion: Excreted mainly as unchanged drug.
Onset of Action for Tranexamic Acid
Duration of Action for Tranexamic Acid
Half Life of Tranexamic Acid
2 hours
Side Effects of Tranexamic Acid
3.Gastrointestinal problems
7.Thrombophlebitis at injected vein
8.Impairment of Colour vision

Contra-indications of Tranexamic Acid
1.Thromboembolic disorders
2.Subarachnoid haemorrhage
3.Massive upper urinary tract haemorrhage
4.Colour vision disorders
6.Hepatic impairment
7.Severe renal impairment

Special Precautions while taking Tranexamic Acid
1.Avoid rapid I.V. administration
2.Lower dosage adjustment is required in renal impairment
3.Monitor liver functioning during long term use
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Tranexamic Acid
1.Surgical procedures
3. Metrorrhagia
4.Post partum haemorrhage
5.Haemorrhage after abortion
6.Haemorrhage due to contraceptive device insertion
7.Tooth extractions and haemorrhage in other dental procedures
10.Gastrointestinal bleeding
14.Ocular trauma
15.Orthopedic surgery
16.Cardiovascular surgery

Interactions for Tranexamic Acid
Typical Dosage for Tranexamic Acid
Oral: 3 to 4gm/day in 3 to 4 divided doses or 15 to 25mg/kg body wt. 3 to 4 times daily.
I.V.: 1.5 to 3gm/day in 3 divided doses or 10 to 15mg/kg body wt. 3 times daily. Administered as slow I.V. injection or as continuous infusion; at a rate of 25 to 50mg/kg/day.

Schedule of Tranexamic Acid
Storage Requirements for Tranexamic Acid
Store below 25 degree C. and protects from light. Keep out of reach of children.

Effects of Missed Dosage of Tranexamic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tranexamic Acid
Treatment is supportive and symptomatic. Remove drug from the body by induced emesis, gastric lavage and administer activated charcoal to reduce absorption. Maintain adequate diuresis with the aid of fluids and diuretics.

Home Delivery for Tranexamic Acid in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tranexamic acid.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tranexamic acid and other medicines and health products. Home delivery services for tranexamic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tranexamic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tranexamic acid before they complete the sale. You can get this information while placing the order for tranexamic acid with the pharmacy.

Tranexamic Acid is a generic medicine name and there are several brands available for it. Some of the brands for tranexamic acid might be better known than tranexamic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tranexamic acid in stock, you can ask for one of the branded alternatives for tranexamic acid.