Aminocaproic Acid Pharmacology

Aminocaproic Acid

About Aminocaproic Acid
Antifibrinolytic Agent, Antihemorrhagic.
Mechanism of Action of Aminocaproic Acid
It is a lysine derivative act as an antifibrinolyte. It reversibly binds to kringle domain of plasminogen and blocks the binding of plasminogen to fibrin. It inhibits the plasminogen activators and it blocks antiplasmin activity by inhibiting fibrinolysis.
Pharmacokinets of Aminocaproic Acid
Absorption: Well absorbed orally, Distribution: Readily penetrates in to blood cells and other body cells. Metabolism: About 11% of drug metabolized in to Adipic acid. Excretion: About 60% of drug is excreted as unchanged drug in urine.
Onset of Action for Aminocaproic Acid
60minutes
Duration of Action for Aminocaproic Acid
N/A
Half Life of Aminocaproic Acid
2hours
Side Effects of Aminocaproic Acid
1.Hypotension
2.Bradycardia
3.Arrhythmias
4.Generalized thrombosis
5.Headache
6.Malaise
7.Dizziness
8.Seizures
9.Hallucinations
10.Weakness
11.Dyspnoea
12.Pulmonary embolism
13.Nasal congestion
14.Nausea
15.Diarrhoea
16.Altered liver function tests
17.Acute renal failure
18.Hyperkalaemia
19.Rash
20.Myopathy
Contra-indications of Aminocaproic Acid
1.Hypersensitivity to the drug
2.Active intravascular clotting or disseminated intravascular coagulation.
Special Precautions while taking Aminocaproic Acid
1.Renal impairment
2.Hepatic impairment
3.Cardiovascular disorders
4.Perform monitoring of coagulation studies, Cardiovascular, Renal functioning tests
5.Avoid long term high dose administration.
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Neonates: Contraindicated.
Indications for Aminocaproic Acid
1.Haemorrhage
2.Antidote for excessive thrombolysis due to administration of streptokinase or urokinase
3.Hereditary telangiectasia
4.Bleeding after prostatic surgery
5.Bleeding after tooth extractions in hemophiliacs
Interactions for Aminocaproic Acid
N/A
Typical Dosage for Aminocaproic Acid
Haemorrhage: Starts with 4 to 5gm; orally or I.V. followed by 1gm/hour for about 8hours or until bleeding is controlled.
Hereditary taelangiectasia: 1 to 1.5mg 12th hourly daily up to 2months followed by 1 to 2g daily
Maximum dose: 30g/day
Schedule of Aminocaproic Acid
H
Storage Requirements for Aminocaproic Acid
Store at controlled room temperature at a range of 15 to 30 degree C.
Effects of Missed Dosage of Aminocaproic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Aminocaproic Acid
Stop the drug immediately after over dosage and perform supportive and symptomatic treatment. Remove drug from the body by haemodialysis.

Home Delivery for Aminocaproic Acid in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including aminocaproic acid.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for aminocaproic acid and other medicines and health products. Home delivery services for aminocaproic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take aminocaproic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for aminocaproic acid before they complete the sale. You can get this information while placing the order for aminocaproic acid with the pharmacy.

Aminocaproic Acid is a generic medicine name and there are several brands available for it. Some of the brands for aminocaproic acid might be better known than aminocaproic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aminocaproic acid in stock, you can ask for one of the branded alternatives for aminocaproic acid.