Factor VIII Pharmacology

Factor VIII

About Factor VIII
Recombinant protein,an essential blood clotting factor(anti-hemophilic factor), Systemic antihemorrhagic agent.
Mechanism of Action of Factor VIII
Factor VIII (anti hemophilic factor) along with Ca2+ and platelet factor helps to convert factor X to Xa (activated form) in intrinsic pathway of coagulation cascade. The factor Xa along with factor V, Ca2+ and platelet factor helps to convert Prothrombin to thrombin; leading ultimately to conversion of fibrinogen to soluble fibrin and finally conversion of soluble fibrin to insoluble fibrin.

Pharmacokinets of Factor VIII
Absorption: Administered intravenously.
Onset of Action for Factor VIII
Duration of Action for Factor VIII
Half Life of Factor VIII
10 to 12 hours
Side Effects of Factor VIII
1. Allergic reactions
2. Dyspnoea
3. Wheezing
4. Tightness in chest
5. Closure of throat
6. Swelling of lips and face
7. Dizziness
8. Fainting
9. Nausea
10. Vomiting
11. Increased heart rate
12. Decreased BP
13. Chest pain
14. Pain, redness and swelling at injected site
15. Headache
16. Flushing

Contra-indications of Factor VIII
1. Hyper sensitivity to the drug
2. Hardening of arteries
Special Precautions while taking Factor VIII
1. Other bleeding or clotting disorders
2. Monitor blood tests during therapy
3. Severe injury or infection.

Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Children Related Information
Indications for Factor VIII
1. Factor VIII deficiency disorders
2. Hemophilia A with bleeding episodes
3. Von Willebrand disease.

Interactions for Factor VIII
Typical Dosage for Factor VIII
30% to 100% factor VIII; intra venously 8th hourly. (100% specifies One IU of anti hemophilic factor/ml of blood).
Minor haemorrhage: 30%
Moderate to major haemorrhage: 40 to 50% 3 to 4days until wound healing
Major haemorrhage: 60 to 100% for 0ne week and continued in the next week to maintain blood level 30 to 50%.
In life threatening or surgical situations initiate the therapy to achieve 100% and then adjust the dosage so that the blood level after 8 hours of an infusion does not fall below 50%.

Schedule of Factor VIII
Storage Requirements for Factor VIII
Store at a temperature range of 2 to 8 degree C. Do not freeze and protect from light.
Effects of Missed Dosage of Factor VIII
The doctor should be informed immediately if a dose is missed
Effects of Overdose of Factor VIII
Give supportive measures and symptomatic treatment.

Home Delivery for Factor VIII in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including factor viii.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for factor viii and other medicines and health products. Home delivery services for factor viii may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take factor viii only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for factor viii before they complete the sale. You can get this information while placing the order for factor viii with the pharmacy.

Factor VIII is a generic medicine name and there are several brands available for it. Some of the brands for factor viii might be better known than factor viii itself. If the pharmacy that's willing to deliver medicines to your home doesn't have factor viii in stock, you can ask for one of the branded alternatives for factor viii.