Tissue Type Plasminogen Activator (TPA) Pharmacology

Tissue Type Plasminogen Activator (TPA)

About Tissue Type Plasminogen Activator (TPA)

Plasminogen activator, A clot-dissolving enzyme (a serine protease), Fibrinolytic.

Mechanism of Action of Tissue Type Plasminogen Activator (TPA)

It exerts it`s fibrinolytic action by activating natural fibrinolytic system. It causes lysis of thrombus or clot and thus recanalyses occluded blood vessels such as coronary artery. It selectively activates gel phase plasminogen; already bound to fibrin to active plasmin (fibrinolysin). Plasmin converts insoluble fibrin to soluble fibrin fragments.

Pharmacokinets of Tissue Type Plasminogen Activator (TPA)

Absorption: Administered intravenously. Distribution: Rapidly cleared from the blood by liver. Metabolism: Metabolized in liver Excretion: Excreted mainly through urine and small amount is excreted through bile.

Onset of Action for Tissue Type Plasminogen Activator (TPA)

Rapid

Duration of Action for Tissue Type Plasminogen Activator (TPA)

4 hours

Half Life of Tissue Type Plasminogen Activator (TPA)

4 to 10 minutes

Side Effects of Tissue Type Plasminogen Activator (TPA)

1.Haemorrhage
2.Allergic reactions
3.Fever
4.Arrhythmias
5.Hypotension
6.Headache
7.Nausea
8.Vomiting
9.Anaphylaxis
10.Urticaria
11.Rash

Contra-indications of Tissue Type Plasminogen Activator (TPA)

1.Hypersensitivity to the drug
2.Bleeding disorders
3.Gastro intestinal tract ulceration
4.Ulcerative wounds
5.In sub acute bacterial endocarditis
6.Acute pancreatitis
7.Severe hypertension
8.Increased capillary permeability
9.Possible internal injuries
10.Cerebrovascular haemorrhage
11.Surgery within 10days
12.10days postpartum
13.Hepatic impairment

Special Precautions while taking Tissue Type Plasminogen Activator (TPA)

1.Renal diseases
2.Liver diseases
3.Recent surgery
4.First 10days postpartum
5.Organ biopsy
6.Cerebrovascular diseases
7.Mitral stenosis
8.Atrial fibrillation
9.Diabetic retinopathy

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Contraindicated

Indications for Tissue Type Plasminogen Activator (TPA)

1.Lysis of thrombi obstructing coronary arteries in myocardial infarction
2.Pulmonary embolism

Interactions for Tissue Type Plasminogen Activator (TPA)

Heparin: Decreased risk of coronary reocclusion.
NSAIDs: Increased risk of GI bleeding.

Typical Dosage for Tissue Type Plasminogen Activator (TPA)

Lysis of thrombi obstructing coronary arteries in myocardial infarction:100mgI.V.; given as 15mg within 1st 1 to 2 minutes followed by 50mg over 30minutes and then 35mg over next one hour.
Pulmonary embolism: 100mg infused over 2hours

Schedule of Tissue Type Plasminogen Activator (TPA)

Storage Requirements for Tissue Type Plasminogen Activator (TPA)

Store at a temperature range of 2 to 8 degree C

Effects of Missed Dosage of Tissue Type Plasminogen Activator (TPA)

The doctor should be informed immediately if a dose is missed

Effects of Overdose of Tissue Type Plasminogen Activator (TPA)

Discontinue the drug during over dosage and restart during stoppage of haemorrhage

Home Delivery for Tissue Type Plasminogen Activator (TPA) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tissue type plasminogen activator (tpa).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tissue type plasminogen activator (tpa) and other medicines and health products. Home delivery services for tissue type plasminogen activator (tpa) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tissue type plasminogen activator (tpa) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tissue type plasminogen activator (tpa) before they complete the sale. You can get this information while placing the order for tissue type plasminogen activator (tpa) with the pharmacy.

Tissue Type Plasminogen Activator (TPA) is a generic medicine name and there are several brands available for it. Some of the brands for tissue type plasminogen activator (tpa) might be better known than tissue type plasminogen activator (tpa) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tissue type plasminogen activator (tpa) in stock, you can ask for one of the branded alternatives for tissue type plasminogen activator (tpa).