Urokinase Pharmacology


About Urokinase
A protease enzyme, a plasminogen activator, A thrombolytic agent.
Mechanism of Action of Urokinase
It exerts it`s fibrinolytic action by activating natural fibrinolytic system. It causes lysis of thrombus or clot and thus recanalyses occluded blood vessels such as coronary artery. It directly activates plasminogen to active plasmin (fibrinolysin). Plasmin converts insoluble fibrin to soluble fibrin fragments.
Pharmacokinets of Urokinase
Absorption: Administered intravenously.
Metabolism: Metabolized in liver.
Excretion: It is rapidly cleared from the circulation and small amount is excreted through urine and bile.
Onset of Action for Urokinase
Duration of Action for Urokinase
4 hours
Half Life of Urokinase
10 to 15 minutes
Side Effects of Urokinase
1. Haemorrhage
2. Allergic reactions
3. Fever
4. Arrhythmias
5. Hypotension or hypertension
6. Bronchospasm
7. Angioedema
8. Anaphylaxis
9. Urticaria
10. Pruritus
11. Flushing

Contra-indications of Urokinase
1. Hypersensitivity to the drug
2. Bleeding disorders
3. Ulcerative wounds
4. In sub acute bacterial endocarditis
5. Severe hypertension
6. Increased capillary permeability
7. Possible internal injuries
8. Cerebrovascular haemorrhage
9. Surgery within 10days
10. 10days postpartum
11. Lumbar puncture
12. Renal impairment
13. Hepatic impairment

Special Precautions while taking Urokinase
1. Renal diseases
2. Liver diseases

Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Urokinase
1. Acute myocardial infarction
2. Pulmonary embolism
3. Venous thrombosis
4. Arterial Thromboembolic disorders
Interactions for Urokinase
Anticoagulants and antiplatelet agents: Carefully monitor since they may cause bleeding complications.
Typical Dosage for Urokinase
Pulmonary embolism: 4400 IU/kg I.V. over 10minutes followed by 4400 IU/kg every hour for 12 hours
Coronary artery thrombosis: 6000 IU/minute intra arterially in to the coronary artery until maximum opening of artery or up to 2 hours of an average total dose of 500000 IU.
Acute myocardial infarction: 2 million IU as I.V. bolus. Alternatively 6000 to 10000 IU/minute intra arterially in to the coronary artery; until maximum opening of artery or up to 2 hours.

Schedule of Urokinase
Storage Requirements for Urokinase
Store at controlled room temperature at a range of 15 to 30 degree C.
Effects of Missed Dosage of Urokinase
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Urokinase
Discontinue the drug during over dosage and restart during stoppage of haemorrhage.

Home Delivery for Urokinase in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including urokinase.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for urokinase and other medicines and health products. Home delivery services for urokinase may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take urokinase only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for urokinase before they complete the sale. You can get this information while placing the order for urokinase with the pharmacy.

Urokinase is a generic medicine name and there are several brands available for it. Some of the brands for urokinase might be better known than urokinase itself. If the pharmacy that's willing to deliver medicines to your home doesn't have urokinase in stock, you can ask for one of the branded alternatives for urokinase.