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- Pharmacology For Aspirin (Low Dose)+ Dipyridamole
Aspirin (Low Dose)+ Dipyridamole Pharmacology
Aspirin (Low Dose)+ DipyridamoleAbout Aspirin (Low Dose)+ DipyridamoleN/AMechanism of Action of Aspirin (Low Dose)+ DipyridamoleN/APharmacokinets of Aspirin (Low Dose)+ DipyridamoleN/AOnset of Action for Aspirin (Low Dose)+ DipyridamoleN/ADuration of Action for Aspirin (Low Dose)+ DipyridamoleN/AHalf Life of Aspirin (Low Dose)+ DipyridamoleN/ASide Effects of Aspirin (Low Dose)+ DipyridamoleN/AContra-indications of Aspirin (Low Dose)+ DipyridamoleN/ASpecial Precautions while taking Aspirin (Low Dose)+ DipyridamoleN/APregnancy Related InformationContraindicated; since Aspirin (low dose) and Dipyridamole are contraindicated in pregnancy. So the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Aspirin (low dose) and Dipyridamole are contraindicated in lactation.Children Related InformationN/AIndications for Aspirin (Low Dose)+ Dipyridamole1. Thromboembolic disorders
3. Peripheral arterial disease
Interactions for Aspirin (Low Dose)+ DipyridamoleN/ATypical Dosage for Aspirin (Low Dose)+ Dipyridamole1 tablet to be taken 3 times daily usually 1 hour before mealsSchedule of Aspirin (Low Dose)+ DipyridamoleN/AStorage Requirements for Aspirin (Low Dose)+ DipyridamoleN/AEffects of Missed Dosage of Aspirin (Low Dose)+ DipyridamoleN/AEffects of Overdose of Aspirin (Low Dose)+ DipyridamoleN/A
Aspirin (Low Dose)About Aspirin (Low Dose)Salicylate, Anti platelet.Mechanism of Action of Aspirin (Low Dose)The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It irreversibly inactivating and inhibiting the enzymes cyclooxygenase and thromboxane-synthetase. At lower doses it selectively suppresses the release of thromboxane-A2 till fresh platelets are formed. It also inhibits the release of ADP from platelets and their sticking to each other.Pharmacokinets of Aspirin (Low Dose)Absorption: Well absorbed orally, Distribution: Widely distributed in the body in a protein bound form, Metabolism: Metabolized in the liver in to metabolites. Excretion: Excreted through urine as salicylates and it`s metabolites.Onset of Action for Aspirin (Low Dose)N/ADuration of Action for Aspirin (Low Dose)5 to 7daysHalf Life of Aspirin (Low Dose)15 to 20minutesSide Effects of Aspirin (Low Dose)1.Prolonged bleeding time
Contra-indications of Aspirin (Low Dose)1.Hypersensitivity to the drug
3.Severe renal impairment
4.Severe hepatic impairment
Special Precautions while taking Aspirin (Low Dose)
4.In gastrointestinal lesions
5.Vitamin K deficiency
6.Thrombotic thrombocytopenic purpura
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Aspirin (Low Dose)Prophylaxis treatment of increased risks of blood clottingInteractions for Aspirin (Low Dose)Drugs Affecting Aspirin:
Activated charcoal: Decreases absorption of aspirin.
Antacids Urinary alkalizers and Cortiosteroids: Decrease efficacy of aspirin.
Drugs affected by aspirin:
Alcohol: Risk of G.I. ulceration increases; may also prolong bleeding time.
ACE inhibitors: Antihypertensive action decreased.
Oral Anticoagulants : May potentiate effect.
Methotrexate: Effect potentiated.
Tetracycline: Efficacy decreased.
Tricyclic Antidepressants - Effect potentiated.
Nitroglycerin: May result in unexpected hypotension.
Beta-adrenergic Blockers - Antihypertensive effect blunted.
NSAIDs: May decrease serum concentration.
Sulfonylureas and Exogenous Insulin: In high doses may potentiate these drugs.
Valproic Acid: Potentiates effect.
Spironolactone: May inhibit diuretic effect.
Probenecid & Sulfinpyrazone : Antagonise uricosuric effect (In doses > 3gm/day - uricosuric effect)
Thyroid Function Tests: Increase in PBI
Serum Uric Acid Levels: Increased by levels less than 10 mg/dl and decreased by levels> 10 mg/dl.
Urine Glucose: False negative by glucose oxidase method. False positive results by reduction method.
Urinary Ketones: Produce reddish colour.Typical Dosage for Aspirin (Low Dose)0ral: 50mg to 160mg/daySchedule of Aspirin (Low Dose)HStorage Requirements for Aspirin (Low Dose)Store at room temperature and protects from moisture.Effects of Missed Dosage of Aspirin (Low Dose)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Aspirin (Low Dose)Empty stomach by induced emesis and gastric lavage. Reduce absorption by administration of activated charcoal. Give symptomatic and supportive treatment. Monitor and assist respiratory function, fluid and electrolyte balance, and other vital parameters. Administer sodium bicarbonate and enhance alkaline diuresis. Haemodialysis is effective in severe poisoning.
DipyridamoleAbout DipyridamoleAntiplatelet Agent(Platelet Aggregation Inhibitor), Vasodilator.Mechanism of Action of DipyridamoleThe drug exerts it`s antithrombotic action by interfering with platelet aggregation. It inhibits phosphodiesterase, blocks uptake and degradation of adenosine (local mediator involved in auto regulation of coronary blood flow in response to ischaemia.), Potentiate prostacyclin (PG I2) and increase cyclic AMP in platelets and interferes with aggregation.Pharmacokinets of DipyridamoleAbsorption: About 27% to 59% of drug is slowly absorbed orally.
Distribution: Widely distributed in a protein bound form and a small portion cross the placental barrier.
Metabolism: Metabolized in the liver.
Excretion: Excreted mainly through bile and small amount is excreted through urine.
Onset of Action for DipyridamoleN/ADuration of Action for DipyridamoleN/AHalf Life of DipyridamoleN/ASide Effects of Dipyridamole1. Headache
5. Abdominal disturbances
6. Hypotension or hypertension
Contra-indications of DipyridamoleNo known contraindicationsSpecial Precautions while taking Dipyridamole1. Hypotension
2. Rapidly progressing angina
3. It shows "coronary steal" phenomenon by dilating resistance vessels in non ischaemic zone as well and diverts already reduced blood flow away from ischaemic zone.
4. Recent myocardial infarction with haemodynamic instability
5. Sub valvular aortic stenosis
Pregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Dipyridamole1. Thromboembolic disorders
2. Angina pectoris
3. Inhibition of platelet adhesion in patients with prosthetic heart valves
Interactions for DipyridamoleOral anti-coagulants & anti-arrhythmic agent Adenosine: Efficacy enhanced by dipyridamole.
Antacids: Reduces efficacy of dipyridamole.
Aminophylline: Reverses vasodilatation effect of dipyridamole.
Aspirin: Useful combination for prevention of thromboembolic phenomenon.Typical Dosage for DipyridamoleOral:
Thromboembolic disorders: Initially 100mg. gradually increases the dosage up to 450mg (in divided doses); as required by the patient.
Angina pectoris: 50mg 8th hourly to be taken 1 hour before meals.
Schedule of DipyridamoleN/AStorage Requirements for DipyridamoleStore at room temperature in a range of 15 to 30 degree C. Protect from moisture.Effects of Missed Dosage of DipyridamoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DipyridamoleGive symptomatic treatment and maintain blood pressure.
Home Delivery for Aspirin (Low Dose)+ Dipyridamole in Your City
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Aspirin (Low Dose)+ Dipyridamole is a generic medicine name and there are several brands available for it. Some of the brands for aspirin (low dose)+ dipyridamole might be better known than aspirin (low dose)+ dipyridamole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aspirin (low dose)+ dipyridamole in stock, you can ask for one of the branded alternatives for aspirin (low dose)+ dipyridamole.