Aspirin (Low Dose)+ Dipyridamole Pharmacology

Aspirin (Low Dose)+ Dipyridamole

About Aspirin (Low Dose)+ Dipyridamole
N/A
Mechanism of Action of Aspirin (Low Dose)+ Dipyridamole
N/A
Pharmacokinets of Aspirin (Low Dose)+ Dipyridamole
N/A
Onset of Action for Aspirin (Low Dose)+ Dipyridamole
N/A
Duration of Action for Aspirin (Low Dose)+ Dipyridamole
N/A
Half Life of Aspirin (Low Dose)+ Dipyridamole
N/A
Side Effects of Aspirin (Low Dose)+ Dipyridamole
N/A
Contra-indications of Aspirin (Low Dose)+ Dipyridamole
N/A
Special Precautions while taking Aspirin (Low Dose)+ Dipyridamole
N/A
Pregnancy Related Information
Contraindicated; since Aspirin (low dose) and Dipyridamole are contraindicated in pregnancy. So the combination generic cannot be used in pregnancy.
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated; since Aspirin (low dose) and Dipyridamole are contraindicated in lactation.
Children Related Information
N/A
Indications for Aspirin (Low Dose)+ Dipyridamole
1. Thromboembolic disorders
2. Stroke
3. Peripheral arterial disease
Interactions for Aspirin (Low Dose)+ Dipyridamole
N/A
Typical Dosage for Aspirin (Low Dose)+ Dipyridamole
1 tablet to be taken 3 times daily usually 1 hour before meals
Schedule of Aspirin (Low Dose)+ Dipyridamole
N/A
Storage Requirements for Aspirin (Low Dose)+ Dipyridamole
N/A
Effects of Missed Dosage of Aspirin (Low Dose)+ Dipyridamole
N/A
Effects of Overdose of Aspirin (Low Dose)+ Dipyridamole
N/A

Aspirin (Low Dose)

About Aspirin (Low Dose)
Salicylate, Anti platelet.
Mechanism of Action of Aspirin (Low Dose)
The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It irreversibly inactivating and inhibiting the enzymes cyclooxygenase and thromboxane-synthetase. At lower doses it selectively suppresses the release of thromboxane-A2 till fresh platelets are formed. It also inhibits the release of ADP from platelets and their sticking to each other.
Pharmacokinets of Aspirin (Low Dose)
Absorption: Well absorbed orally, Distribution: Widely distributed in the body in a protein bound form, Metabolism: Metabolized in the liver in to metabolites. Excretion: Excreted through urine as salicylates and it`s metabolites.
Onset of Action for Aspirin (Low Dose)
N/A
Duration of Action for Aspirin (Low Dose)
5 to 7days
Half Life of Aspirin (Low Dose)
15 to 20minutes
Side Effects of Aspirin (Low Dose)
1.Prolonged bleeding time
2.Thrombocytopenia
3.Gastrointestinal disturbances
4.Allergic reactions
5.Rash
6.Urticaria
7.Angioedema
Contra-indications of Aspirin (Low Dose)
1.Hypersensitivity to the drug
2.Peptic ulcer
3.Severe renal impairment
4.Severe hepatic impairment
5.G6PD deficiency
6.Haemorrhagic disorders
Special Precautions while taking Aspirin (Low Dose)

1.Hypo prothrobinemia
2.Renal impairment
3.Hepatic impairment
4.In gastrointestinal lesions
5.Vitamin K deficiency
6.Thrombotic thrombocytopenic purpura
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Aspirin (Low Dose)
Prophylaxis treatment of increased risks of blood clotting
Interactions for Aspirin (Low Dose)
Drugs Affecting Aspirin:
Activated charcoal: Decreases absorption of aspirin.
Antacids Urinary alkalizers and Cortiosteroids: Decrease efficacy of aspirin.

Drugs affected by aspirin:
Alcohol: Risk of G.I. ulceration increases; may also prolong bleeding time.
ACE inhibitors: Antihypertensive action decreased.
Oral Anticoagulants : May potentiate effect.
Methotrexate: Effect potentiated.
Tetracycline: Efficacy decreased.
Tricyclic Antidepressants - Effect potentiated.
Nitroglycerin: May result in unexpected hypotension.
Beta-adrenergic Blockers - Antihypertensive effect blunted.
NSAIDs: May decrease serum concentration.
Sulfonylureas and Exogenous Insulin: In high doses may potentiate these drugs.
Valproic Acid: Potentiates effect.
Spironolactone: May inhibit diuretic effect.
Probenecid & Sulfinpyrazone : Antagonise uricosuric effect (In doses > 3gm/day - uricosuric effect)
Lab Tests:
Thyroid Function Tests: Increase in PBI
Serum Uric Acid Levels: Increased by levels less than 10 mg/dl and decreased by levels> 10 mg/dl.
Urine Glucose: False negative by glucose oxidase method. False positive results by reduction method.
Urinary Ketones: Produce reddish colour.
Typical Dosage for Aspirin (Low Dose)
0ral: 50mg to 160mg/day
Schedule of Aspirin (Low Dose)
H
Storage Requirements for Aspirin (Low Dose)
Store at room temperature and protects from moisture.
Effects of Missed Dosage of Aspirin (Low Dose)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Aspirin (Low Dose)
Empty stomach by induced emesis and gastric lavage. Reduce absorption by administration of activated charcoal. Give symptomatic and supportive treatment. Monitor and assist respiratory function, fluid and electrolyte balance, and other vital parameters. Administer sodium bicarbonate and enhance alkaline diuresis. Haemodialysis is effective in severe poisoning.

Dipyridamole

About Dipyridamole
Antiplatelet Agent(Platelet Aggregation Inhibitor), Vasodilator.
Mechanism of Action of Dipyridamole
The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It inhibits phosphodiesterase, blocks uptake and degradation of adenosine (local mediator involved in auto regulation of coronary blood flow in response to ischaemia.), Potentiate prostacyclin (PG I2) and increase cyclic AMP in platelets and interferes with aggregation.
Pharmacokinets of Dipyridamole
Absorption: About 27% to 59% of drug is slowly absorbed orally.
Distribution: Widely distributed in a protein bound form and a small portion cross the placental barrier.
Metabolism: Metabolized in the liver.
Excretion: Excreted mainly through bile and small amount is excreted through urine.
Onset of Action for Dipyridamole
N/A
Duration of Action for Dipyridamole
N/A
Half Life of Dipyridamole
N/A
Side Effects of Dipyridamole
1. Headache
2. Dizziness
3. Rash
4. Nausea
5. Abdominal disturbances
6. Hypotension or hypertension

Contra-indications of Dipyridamole
No known contraindications
Special Precautions while taking Dipyridamole
1. Hypotension
2. Rapidly progressing angina
3. It shows "coronary steal" phenomenon by dilating resistance vessels in non ischaemic zone as well and diverts already reduced blood flow away from ischaemic zone.
4. Recent myocardial infarction with haemodynamic instability
5. Sub valvular aortic stenosis
Pregnancy Related Information
Contraindicated
Old Age Related Information
May be used
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Dipyridamole
1. Thromboembolic disorders
2. Angina pectoris
3. Inhibition of platelet adhesion in patients with prosthetic heart valves

Interactions for Dipyridamole
Oral anti-coagulants & anti-arrhythmic agent Adenosine: Efficacy enhanced by dipyridamole.
Antacids: Reduces efficacy of dipyridamole.
Aminophylline: Reverses vasodilatation effect of dipyridamole.
Aspirin: Useful combination for prevention of thromboembolic phenomenon.
Typical Dosage for Dipyridamole
Oral:
Thromboembolic disorders: Initially 100mg. gradually increases the dosage up to 450mg (in divided doses); as required by the patient.
Angina pectoris: 50mg 8th hourly to be taken 1 hour before meals.

Schedule of Dipyridamole
N/A
Storage Requirements for Dipyridamole
Store at room temperature in a range of 15 to 30 degree C. Protect from moisture.
Effects of Missed Dosage of Dipyridamole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dipyridamole
Give symptomatic treatment and maintain blood pressure.

Home Delivery for Aspirin (Low Dose)+ Dipyridamole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including aspirin (low dose)+ dipyridamole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for aspirin (low dose)+ dipyridamole and other medicines and health products. Home delivery services for aspirin (low dose)+ dipyridamole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take aspirin (low dose)+ dipyridamole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for aspirin (low dose)+ dipyridamole before they complete the sale. You can get this information while placing the order for aspirin (low dose)+ dipyridamole with the pharmacy.

Aspirin (Low Dose)+ Dipyridamole is a generic medicine name and there are several brands available for it. Some of the brands for aspirin (low dose)+ dipyridamole might be better known than aspirin (low dose)+ dipyridamole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aspirin (low dose)+ dipyridamole in stock, you can ask for one of the branded alternatives for aspirin (low dose)+ dipyridamole.