Isoxsuprine Pharmacology


About Isoxsuprine
A beta-adrenergic agonist, Tocolytic agent,Peripheral vasodilator.
Mechanism of Action of Isoxsuprine
The drug exerts vasodilatory and smooth muscle relaxant action through acting as a beta adrenergic receptor agonist. It relaxes veins and arteries and causes dilatation and thus improves blood flow through them. It causes uterine relaxation due to it`s direct smooth muscle relaxant action.
Pharmacokinets of Isoxsuprine
Absorption: Well absorbed orally and also administered parenterally.
Metabolism: Metabolized in liver by partial conjugation.
Excretion: Excreted mainly through urine.
Onset of Action for Isoxsuprine
I.V.: Rapid
Oral: 30 to 60 minutes
Duration of Action for Isoxsuprine
6 to 8 hours
Half Life of Isoxsuprine
1.25 hours
Side Effects of Isoxsuprine
1. Palpitation
2. Flushing
3. Tachycardia
4. Dizziness
5. Hypotension
6. Abdominal disturbances
7. Nausea
8. Vomiting
9. Rash
10. Allergic reactions
11. Oedema
Contra-indications of Isoxsuprine
1. Recent arterial haemorrhage
2. Immediately postpartum
3. Premature detachment of placenta
4. Parenteral form contraindicated in heart diseases
5. Severe anaemia
Special Precautions while taking Isoxsuprine
1. Renal impairment
2. Hepatic impairment
3. In cardio vascular disorders such as heart failure, severe angina, peripheral arterial diseases, resent myocardial infarction etc.
4. Along with other medication
5. Hyperthyroidism

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Isoxsuprine
1. Cerebral and peripheral vascular diseases
2. Prevention of premature labour and threatened abortion.

Interactions for Isoxsuprine
Typical Dosage for Isoxsuprine
Cerebral and peripheral vascular diseases:
Starts with 20mg; 6th hourly. Reduces the dosage up to 10mg 8th hourly based on patient`s response.
I.V.: Initially at an infusion rate of 0.3mg/minute. Then adjust the dosage based on the patient`s response.
I.M.: Initially 5mg 8th hourly and gradually increases to 10 to 20mg 8th hourly.
Prevention of premature labour and threatened abortion:
I.V.: Initially at an infusion rate of 0.3mg/minute. Then adjust the dosage based on the patient`s response.
I.M.:10mg at intervals of 60 to 120 minutes
Oral: 20mg 6th hourly or 40mg (sustained release) 12th hourly. Reduces the dosage based on patient`s response.

Schedule of Isoxsuprine
Storage Requirements for Isoxsuprine
Store at room temperature at a range of 15 to 30 degree C. away from heat, light, and moisture.
Effects of Missed Dosage of Isoxsuprine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Isoxsuprine
Give supportive measures and symptomatic treatment.

Home Delivery for Isoxsuprine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including isoxsuprine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for isoxsuprine and other medicines and health products. Home delivery services for isoxsuprine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take isoxsuprine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for isoxsuprine before they complete the sale. You can get this information while placing the order for isoxsuprine with the pharmacy.

Isoxsuprine is a generic medicine name and there are several brands available for it. Some of the brands for isoxsuprine might be better known than isoxsuprine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have isoxsuprine in stock, you can ask for one of the branded alternatives for isoxsuprine.