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- Pharmacology For Gemfibrozil
GemfibrozilAbout GemfibrozilFibric Acid Derivative, Antilipemic agent.Mechanism of Action of GemfibrozilThe drug lowers circulating triglyceride levels by activating lipoprotein lipase which is a key enzyme in the degradation of VLDL (very low density lipoprotein) cholesterol. This effect is exerted through paroxisome proliferator-activated receptor alpha (PPARalpha) which enhances lipoprotein lipase synthesis and fatty acid oxidation. It also reduces hepatic triglyceride synthesis. It also reduces VLDL secretion by liver and increases HDL (high density lipoprotein) cholesterol. The increase in HDL cholesterol is partly due to transfer of surface lipid components from catabolised VLDL to HDL and also due to increased production of HDL apoproteins by liver. The small dense LDL have been shifted to larger less dense particles. It is highly effective in type III hyperlipoproteinemia and lowers raised blood cholesterol. It also exerts antiatherosclerotic effect by promoting fibrinolysis; by decreasing the level of clotting factor VII-phospholipid complex.Pharmacokinets of GemfibrozilAbsorption: Well absorbed orally
Distribution: Widely distributed in a protein bound form.
Metabolism: Metabolized by glucuronide conjugation in liver.
Excretion: Excreted mainly through urine and a small portion is excreted through faeces.
Onset of Action for Gemfibrozil2 to 5 daysDuration of Action for GemfibrozilN/AHalf Life of Gemfibrozil90 minutesSide Effects of Gemfibrozil1. Abdominal discomfort
2. Epigastric pain
3. Loose motions
9. Acute appendicitis
10. Bile duct obstruction
11. Elevated liver enzymes
15. Blurred vision
17. Atrial fibrillation
Contra-indications of Gemfibrozil1. Hypersensitivity to the drug
2. Severe hepatic impairment
3. Severe renal impairment
4. Gall bladder disease
5. Type-1 hyperlipoproteinemia
Special Precautions while taking Gemfibrozil1. Monitor lipid profile, blood count, and hepatic function before and periodically during therapy.
2. If response is inadequate after 3 months therapy.
Pregnancy Related InformationContraindicated
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Gemfibrozil1. Hyper lipidaemia
2. Lipoprotein abnormalities and hypercholesterolemia unresponsive to diet alone.
Interactions for GemfibrozilOral anticoagulants: Efficacy of oral anticoagulants enhanced requiring adjustment in their dosage.
Lovastatin: Rhabdomyolysis (myositis) has occured as early as three weeks after combined therapy.Typical Dosage for GemfibrozilOral: 1.2g/day as two divided doses 30minutes before morning and evening meals
Or 900mg once daily; 30minutes before evening meals.
Maximum dose: 1.5gm/day
Schedule of GemfibrozilHStorage Requirements for GemfibrozilStore at controlled room temperature at a range of 15 to 25 degree C. Protect from light and humidityEffects of Missed Dosage of GemfibrozilTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of GemfibrozilDrug is removed from the body by induced emesis and gastric lavage. Treatment is supportive and symptomatic.
Home Delivery for Gemfibrozil in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including gemfibrozil.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for gemfibrozil and other medicines and health products. Home delivery services for gemfibrozil may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take gemfibrozil only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for gemfibrozil before they complete the sale. You can get this information while placing the order for gemfibrozil with the pharmacy.
Gemfibrozil is a generic medicine name and there are several brands available for it. Some of the brands for gemfibrozil might be better known than gemfibrozil itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gemfibrozil in stock, you can ask for one of the branded alternatives for gemfibrozil.