Pravastatin Sodium Pharmacology

Pravastatin Sodium

About Pravastatin Sodium
HMG-CoA reductase inhibitor,statins, Antilipemic.
Mechanism of Action of Pravastatin Sodium
It is an active hydrophilic statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 25% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels. It has only little effects on cholesterol synthesis in other tissues It also decreases plasma fibrinogen levels.
Pharmacokinets of Pravastatin Sodium
Absorption: About 34% of drug is rapidly absorbed orally, and bioavailability is about 17%. Distribution: Distributed in to the liver by extensive first pass hepatic extraction and about 50% of drug is plasma protein bound, Metabolism: Metabolized in liver in to both active and inactive metabolites, Excretion: Excreted mainly through bile and rest is excreted through urine.
Onset of Action for Pravastatin Sodium
Duration of Action for Pravastatin Sodium
Half Life of Pravastatin Sodium
77 hours
Side Effects of Pravastatin Sodium
2.Abdominal discomfort
3.Heart burn
4.Abdominal pain
9.Abnormal liver function tests
10.Abnormal thyroid function tests
11.Urinary abnormality
17.Chest pain
20.Upper respiratory tract infections

Contra-indications of Pravastatin Sodium
1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels

Special Precautions while taking Pravastatin Sodium
1.Monitor hepatic and liver function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
3.Renal impairment
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Pravastatin Sodium
2.Hyper lipoproteinemia
3.Primary prevention of coronary events
Interactions for Pravastatin Sodium
Bile Acid Sequestrants (BAS): When pravastatin is administered 1hour before or 4 hours after BAS, there is no clinically significant decrease in bioavailability or therapeutic effect.
Gemfibrozil : Combination therapy generally not recommended.
Typical Dosage for Pravastatin Sodium
Starts with 10mg to 20mg once daily; at bed time. Increased if required based on patients response.
Maximum dose: 40mg

Schedule of Pravastatin Sodium
Storage Requirements for Pravastatin Sodium
Store at room temperature at a range of 15 to 25 degree C. Protect from moisture and light.
Effects of Missed Dosage of Pravastatin Sodium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Pravastatin Sodium
Provide supportive care and symptomatic treatment.

Home Delivery for Pravastatin Sodium in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pravastatin sodium and other medicines and health products. Home delivery services for pravastatin sodium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take pravastatin sodium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pravastatin sodium before they complete the sale. You can get this information while placing the order for pravastatin sodium with the pharmacy.

Pravastatin Sodium is a generic medicine name and there are several brands available for it. Some of the brands for pravastatin sodium might be better known than pravastatin sodium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pravastatin sodium in stock, you can ask for one of the branded alternatives for pravastatin sodium.