Rosuvastatin Pharmacology

Rosuvastatin

About Rosuvastatin

Statin, HMG-CoA Reductase Inhibitor, Antilipemic.

Mechanism of Action of Rosuvastatin

It is a hypolipidaemic statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels.

Pharmacokinets of Rosuvastatin

Absorption: Readily absorbed orally, and bioavailability is about 20%. Distribution: Widely distributed in a protein bound form, Metabolism: Not significantly metabolized in liver, only about 10% is metabolized in liver. Excretion: Excreted mainly through bile.

Onset of Action for Rosuvastatin

N/A

Duration of Action for Rosuvastatin

N/A

Half Life of Rosuvastatin

20 hours

Side Effects of Rosuvastatin

1.Headache
2.Dizziness
3.Insomnia
4.Asthenia
5.Abdominal discomfort
6.Heart burn
7.Abdominal pain
8.Nausea
9.Dyspepsia
10.Flatulence
11.Constipation
12.Abnormal liver function tests
13.Rash
14.Fatigue
15.Myositis
16.Chest pain
17.Myopathy
18.Upper respiratory tract infections

Contra-indications of Rosuvastatin

1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
4.Severe renal impairment

Special Precautions while taking Rosuvastatin

1.Monitor hepatic and renal function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
3.Alcoholics
4.In severe adverse effects and Myopathy

Pregnancy Related Information

Contraindicated

Old Age Related Information

May be used

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated below 9 years of age

Indications for Rosuvastatin

1.Hypercholesterolemia as an adjunct to diet
2.Mixed dyslipidaemia as an adjunct to diet

Interactions for Rosuvastatin

Rosuvastatin appears to have a low propensity for pharmacokinetic drug interactions. Caution should be exercised in patients receiving concomitant cyclosporin.

Typical Dosage for Rosuvastatin

Oral:
Initially 5mg to 10mg once daily; increased if required at four week intervals based on patient`s response.
Maximum dose: 40mg

Schedule of Rosuvastatin

Storage Requirements for Rosuvastatin

Store at room temperature below 25 degree C.

Effects of Missed Dosage of Rosuvastatin

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose

Effects of Overdose of Rosuvastatin

Provide supportive care and symptomatic treatment

Home Delivery for Rosuvastatin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including rosuvastatin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for rosuvastatin and other medicines and health products. Home delivery services for rosuvastatin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take rosuvastatin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for rosuvastatin before they complete the sale. You can get this information while placing the order for rosuvastatin with the pharmacy.

Rosuvastatin is a generic medicine name and there are several brands available for it. Some of the brands for rosuvastatin might be better known than rosuvastatin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rosuvastatin in stock, you can ask for one of the branded alternatives for rosuvastatin.