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- Pharmacology For Atorvastatin + Nicotinic acid
Atorvastatin + Nicotinic acid Pharmacology
Atorvastatin + Nicotinic acidAbout Atorvastatin + Nicotinic acidN/AMechanism of Action of Atorvastatin + Nicotinic acidN/APharmacokinets of Atorvastatin + Nicotinic acidN/AOnset of Action for Atorvastatin + Nicotinic acidN/ADuration of Action for Atorvastatin + Nicotinic acidN/AHalf Life of Atorvastatin + Nicotinic acidN/ASide Effects of Atorvastatin + Nicotinic acidN/AContra-indications of Atorvastatin + Nicotinic acidN/ASpecial Precautions while taking Atorvastatin + Nicotinic acidN/APregnancy Related InformationContraindicated; since Atorvastatin is contraindicated in Pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Atorvastatin is contraindicated in breast feeding mother. The combination generic cannot be used in LactationChildren Related InformationN/AIndications for Atorvastatin + Nicotinic acidHyperlipidaemiaInteractions for Atorvastatin + Nicotinic acidN/ATypical Dosage for Atorvastatin + Nicotinic acid1 tablet / day with mealsSchedule of Atorvastatin + Nicotinic acidN/AStorage Requirements for Atorvastatin + Nicotinic acidN/AEffects of Missed Dosage of Atorvastatin + Nicotinic acidN/AEffects of Overdose of Atorvastatin + Nicotinic acidN/A
AtorvastatinAbout AtorvastatinHMG-CoA Reductase Inhibitor, statins, Antilipemic agent.Mechanism of Action of AtorvastatinIt is a more potent statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels. It also exerts antioxidant property.Pharmacokinets of AtorvastatinAbsorption: Readily absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in liver in to active metabolite, Excretion: Excreted mainly through bile.Onset of Action for AtorvastatinN/ADuration of Action for AtorvastatinN/AHalf Life of Atorvastatin18 to 24 hoursSide Effects of Atorvastatin1.Headache
13.Abnormal liver function tests
21.Upper respiratory tract infections
Contra-indications of Atorvastatin1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
Special Precautions while taking Atorvastatin
1.Monitor hepatic function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
4.In severe adverse effects and fever
Pregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Below 9years: ContraindicatedIndications for Atorvastatin1.Hypercholesterolemia
Interactions for AtorvastatinN/ATypical Dosage for AtorvastatinOral:
Starts with 10mg once daily; Increased if required based on patients response.
Maximum dose: 80mg
Schedule of AtorvastatinHStorage Requirements for AtorvastatinStore at room temperature at a range of 15 to 25 degree C.Effects of Missed Dosage of AtorvastatinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AtorvastatinProvide supportive care and symptomatic treatment.
Nicotinic AcidAbout Nicotinic AcidN/AMechanism of Action of Nicotinic AcidNiacin refers to Nicotinic acid as well as Nicotinamide which exerts it`s action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and its phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.Pharmacokinets of Nicotinic AcidAbsorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.Onset of Action for Nicotinic AcidN/ADuration of Action for Nicotinic AcidN/AHalf Life of Nicotinic AcidN/ASide Effects of Nicotinic Acid1. Flushing
2. Activation of peptic ulcer
11. Hepatic impairment
Contra-indications of Nicotinic Acid1. Hypersensitivity to the drug
2. Hepatic impairment
3. Peptic ulcer
4. Severe hypotension
5. Arterial haemorrhage
Special Precautions while taking Nicotinic Acid1.History of liver disease
2.Gall bladder diseases
4.Coronary artery diseases
6.When use along with Statins reduces the dosage of StatinsPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Nicotinic Acid1. Pellagra
2. Niacin deficiency
3. Hartnup disease
4. Hyperlipidaemia (only nicotinic acid
5. Peripheral vascular diseases (only nicotinic acid)Interactions for Nicotinic AcidN/ATypical Dosage for Nicotinic AcidOral:
Peripheral vascular diseases: 100 to 150mg three to five times daily. Alternatively 1000 to 2000g once daily at bed time.
Hyperlipidaemia: 1.5 to 6g daily in two to four divided doses with or after meals.
Schedule of Nicotinic AcidC1Storage Requirements for Nicotinic AcidStore at controlled room temperature at a range of 15 to 30 degree CEffects of Missed Dosage of Nicotinic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Nicotinic AcidProvide supportive measures and symptomatic treatment
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Atorvastatin + Nicotinic acid is a generic medicine name and there are several brands available for it. Some of the brands for atorvastatin + nicotinic acid might be better known than atorvastatin + nicotinic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have atorvastatin + nicotinic acid in stock, you can ask for one of the branded alternatives for atorvastatin + nicotinic acid.