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- Pharmacology For Simvastatin + Ezetimibe
Simvastatin + Ezetimibe Pharmacology
Simvastatin + EzetimibeAbout Simvastatin + EzetimibeN/AMechanism of Action of Simvastatin + EzetimibeN/APharmacokinets of Simvastatin + EzetimibeN/AOnset of Action for Simvastatin + EzetimibeN/ADuration of Action for Simvastatin + EzetimibeN/AHalf Life of Simvastatin + EzetimibeN/ASide Effects of Simvastatin + EzetimibeN/AContra-indications of Simvastatin + EzetimibeN/ASpecial Precautions while taking Simvastatin + EzetimibeN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Simvastatin + EzetimibeN/AInteractions for Simvastatin + EzetimibeN/ATypical Dosage for Simvastatin + EzetimibeN/ASchedule of Simvastatin + EzetimibeN/AStorage Requirements for Simvastatin + EzetimibeN/AEffects of Missed Dosage of Simvastatin + EzetimibeN/AEffects of Overdose of Simvastatin + EzetimibeN/A
SimvastatinAbout SimvastatinStatins, HMG-CoA reductase inhibitor, A hypolipidemic agent.Mechanism of Action of SimvastatinIt is a precursor lactone converted in to active form in the body which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It increases high density lipoprotein (HDL) levels than other statins.Pharmacokinets of SimvastatinAbsorption: Readily absorbed orally but extensive fist pass hepatic metabolism limits bioavailability, Distribution: Distributed mainly to liver in a highly protein bound form and less than 5%of an oral dose reaches systemic circulation, Metabolism: Metabolized in liver in to active metabolite, Excretion: Excreted mainly through bile.Onset of Action for SimvastatinSignificant response seen after 1 to 2 weeks maximum therapeutic response seen after 4 to 6 weeks.Duration of Action for SimvastatinN/AHalf Life of Simvastatin3 hoursSide Effects of Simvastatin1.Headache
11.Abnormal liver function tests
16. Upper respiratory tract infections
Contra-indications of Simvastatin1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
Special Precautions while taking Simvastatin1.Renal impairment
2.History of liver diseases
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Simvastatin1.Hypercholesterolemia(types IIa, IIb)
2.Hypercholesterolemia along with hypertriglyceridemia)
Interactions for SimvastatinCyclosporine, erythromycin, niacin, gemfibrozil: Severe myopathy or rhabdomyolysis.
Propranolol: Decrease in antihyperlipidaemic activity.
Itraconazole: Plasma levels of lovastatin increased 20-fold.
Warfarin: Anticoagulant effect increased, chances of bleeding.Typical Dosage for SimvastatinOral:
Starts with 5 to 10mg once daily; with evening meals. Increased if required based on patients response at every four weeks.
Maximum dose: 40mg
Schedule of SimvastatinHStorage Requirements for SimvastatinStore at room temperature at a range of 15 to 25 degree C.Effects of Missed Dosage of SimvastatinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of SimvastatinProvide supportive care and symptomatic treatment.
EzetimibeAbout EzetimibeCholesterol Absorption Inhibitor, 2-Azetidinone derivative, Hypolipidemic agent.Mechanism of Action of EzetimibeIt reduces the absorption of cholesterol from the intestine by localising at the brush border of the small intestine, where it inhibits the absorption of cholesterol from the diet. Specifically, it appears to bind to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelium, a critical mediator of cholesterol absorption. This decreased cholesterol absorption leads to an increase in LDL-cholesterol uptake into cells, thus decreasing levels in the blood plasma.Pharmacokinets of EzetimibeAbsorption- Poorly absorbed after oral administration
Distribution- Widely distributed in the body as plasma protein binding form (>90%)
Metabolism- Metabolized in the liver and intestinal wall
Excretion- Excreted through urine and feces
Onset of Action for EzetimibeN/ADuration of Action for EzetimibeN/AHalf Life of Ezetimibe19-30 hoursSide Effects of Ezetimibe1. Difficulty breathing
2. Closing of the throat
3. Swelling of the lips, tongue, or face
4. Abdominal pain
9. Sore throat
10. Runny nose
12. Joint pain
16. Upset stomach
17. Unusual bleeding or bruising
18. Loss of appetite
19. Pain in the upper right part of the stomach
20. Yellowing of the skin or eyes
21. flu-like symptoms
22. Muscle pain or weakness
25. Pale or fatty stools
26. Chest pain
Contra-indications of EzetimibeContraindicated in patients with hypersensitivity to the drug or any components of it
Special Precautions while taking Ezetimibe1. Liver disease
2. Liver enzymes, persistently high levels
3. Major surgery or serious illness
4. Diabetes mellitus
5. Kidney disease
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ezetimibe1. Adjunct to dietary measures and statin in primary and homozygous familial hypercholesterolaemia
2. Adjunct to dietary measures in homozygous familial sitosterolaemia
Interactions for EzetimibeCyclosporin: Plasma concentraction of ezetimibe increased. Lipid-regulating drugs: Avoid concomitant use with fibrates.Typical Dosage for EzetimibeOral-
Adult -10 mg/day
Schedule of EzetimibeN/AStorage Requirements for EzetimibeStored at room temperature (15-30 degree C).Effects of Missed Dosage of EzetimibeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of EzetimibeGive symptomatic and supportive treatment
Home Delivery for Simvastatin + Ezetimibe in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for simvastatin + ezetimibe and other medicines and health products. Home delivery services for simvastatin + ezetimibe may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take simvastatin + ezetimibe only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for simvastatin + ezetimibe before they complete the sale. You can get this information while placing the order for simvastatin + ezetimibe with the pharmacy.
Simvastatin + Ezetimibe is a generic medicine name and there are several brands available for it. Some of the brands for simvastatin + ezetimibe might be better known than simvastatin + ezetimibe itself. If the pharmacy that's willing to deliver medicines to your home doesn't have simvastatin + ezetimibe in stock, you can ask for one of the branded alternatives for simvastatin + ezetimibe.