Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium Pharmacology

Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium

About Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Mechanism of Action of Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Pharmacokinets of Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Onset of Action for Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Duration of Action for Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Half Life of Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Side Effects of Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Contra-indications of Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Special Precautions while taking Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Interactions for Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Typical Dosage for Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Schedule of Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Storage Requirements for Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Effects of Missed Dosage of Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Effects of Overdose of Atorvastatin + Co Enzyme Q10 + Vitamin E + Zinc + Selenium
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Atorvastatin

About Atorvastatin
HMG-CoA Reductase Inhibitor, statins, Antilipemic agent.
Mechanism of Action of Atorvastatin
It is a more potent statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels. It also exerts antioxidant property.
Pharmacokinets of Atorvastatin
Absorption: Readily absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in liver in to active metabolite, Excretion: Excreted mainly through bile.
Onset of Action for Atorvastatin
N/A
Duration of Action for Atorvastatin
N/A
Half Life of Atorvastatin
18 to 24 hours
Side Effects of Atorvastatin
1.Headache
2.Dizziness
3.Insomnia
4.Alopecia
5.Anorexia
6.Abdominal discomfort
7.Heart burn
8.Abdominal pain
9.Nausea
10.Dyspepsia
11.Flatulence
12.Constipation
13.Abnormal liver function tests
14.Rash
15.Pruritus
16.Fatigue
17.Myositis
18.Chest pain
19.Impotence
20.Myopathy
21.Upper respiratory tract infections

Contra-indications of Atorvastatin
1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
Special Precautions while taking Atorvastatin

1.Monitor hepatic function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
3.Alcoholics
4.In severe adverse effects and fever


Pregnancy Related Information
Contraindicated
Old Age Related Information
May be used
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Below 9years: Contraindicated
Indications for Atorvastatin
1.Hypercholesterolemia
2.Combined hyperlipidaemia
Interactions for Atorvastatin
N/A
Typical Dosage for Atorvastatin
Oral:
Starts with 10mg once daily; Increased if required based on patients response.
Maximum dose: 80mg
Schedule of Atorvastatin
H
Storage Requirements for Atorvastatin
Store at room temperature at a range of 15 to 25 degree C.
Effects of Missed Dosage of Atorvastatin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Atorvastatin
Provide supportive care and symptomatic treatment.

Co Enzyme Q10

About Co Enzyme Q10
1,4-benzoquinone derivative, oil-soluble vitamin-like substance, Enzyme cofactors, powerful antioxidant
Mechanism of Action of Co Enzyme Q10
Coenzyme Q10 is vital for the proper transfer of electrons within the mitochondrial oxidative respiratory chain there it passes reducing equivalents to acceptors such as Coenzyme Q: cytochrome c - oxidoreductase:
CoQH2+ 2 FeIII-cytochrome c ? CoQ + 2 FeII-cytochrome c. main function of this transport is adenosine triphosphate production. Coenzyme Q10 also increases adenosine triphosphate levels by preventing the loss of the adenine nucleotide pool from cardiac cells. Coenzyme Q10 has activity as an antioxidant scavenger and an indirect stabilizer of calcium channels to decrease calcium overload. It also inhibits the oxidation of LDL-cholesterol. LDL-cholesterol oxidation is believed to play a significant role in the pathogenesis of atherosclerosis.
Pharmacokinets of Co Enzyme Q10
Absorption- Poorly absorbed after oral administration. Excretion- Excreted through bile and feces
Onset of Action for Co Enzyme Q10
N/A
Duration of Action for Co Enzyme Q10
N/A
Half Life of Co Enzyme Q10
N/A
Side Effects of Co Enzyme Q10
1. Nausea
2. Vomiting
3. Stomach upset
4. Heartburn
5. Diarrhea
6. Loss of appetite
7. Skin itching
8. Rash
9. Insomnia
10. Headache
11. Dizziness
12. Irritability
13. Increased light sensitivity of the eyes
14. Fatigue
15. Flu-like symptoms
Contra-indications of Co Enzyme Q10
N/A
Special Precautions while taking Co Enzyme Q10
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Co Enzyme Q10
1. Dietary supplement
2. Antioxidant
3. Migraine headaches
4. Parkinson`s Disease
5. Mitochondrial Encephalomyopathies
6. Migraine
7. CHF
8. Hypertension
9. Diabetes
10. Cancer
Interactions for Co Enzyme Q10
N/A
Typical Dosage for Co Enzyme Q10
Adult-
Oral-
Mitochondrial cytopathies: 150 mg per day or 2 mg per kg per day with titration up to 3,000 mg per day in some patients
Parkinson`s disease: 300 to 1,200 mg per day in four divided doses
Cardiovascular problems: 50 to 200 mg per day
Migraine 100 to 200 mg per day
Schedule of Co Enzyme Q10
N/A
Storage Requirements for Co Enzyme Q10
Keep tightly closed in a dry place. Do not expose to excessive heat.
Effects of Missed Dosage of Co Enzyme Q10
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.
Effects of Overdose of Co Enzyme Q10
Give supportive measures and symptomatic treatment.

Vitamin E

About Vitamin E
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Mechanism of Action of Vitamin E
Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.
Pharmacokinets of Vitamin E
Absorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.
Onset of Action for Vitamin E
N/A
Duration of Action for Vitamin E
N/A
Half Life of Vitamin E
N/A
Side Effects of Vitamin E
1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence


Contra-indications of Vitamin E
1. Hypersensitivity to the drug
2. Should not administer intravenously
Special Precautions while taking Vitamin E
1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens
Pregnancy Related Information
May be used
Old Age Related Information
N/A
Breast Feeding Related Information
May be used
Children Related Information
N/A
Indications for Vitamin E
1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant


Interactions for Vitamin E
Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.

Typical Dosage for Vitamin E
Oral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.



Schedule of Vitamin E
C1
Storage Requirements for Vitamin E
Store in a well closed container in a cool dry place. Protect from light.
Effects of Missed Dosage of Vitamin E
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin E
Provide supportive measures and symptomatic treatment.

Zinc

About Zinc
Trance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.
Mechanism of Action of Zinc
Zinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.
Pharmacokinets of Zinc
Absorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.
Onset of Action for Zinc
N/A
Duration of Action for Zinc
N/A
Half Life of Zinc
N/A
Side Effects of Zinc
1. Nausea
2. Vomiting
3. Abdominal distress
4. Gastric ulceration
5. Rashes
Contra-indications of Zinc
N/A
Special Precautions while taking Zinc
1.Don`t exceed prescribed dose
2.Renal failure
3.Biliary obstruction

Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Zinc
1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
6. Alopecia
Interactions for Zinc
Fluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.

Typical Dosage for Zinc
Adults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.
Schedule of Zinc
N/A
Storage Requirements for Zinc
Store at a temperature below 30 degree C
Effects of Missed Dosage of Zinc
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Zinc
Provide symptomatic treatment and supportive measures

Selenium

About Selenium
A vital antioxidant, selenium acts with vitamin E to protect the immune system and maintain healthy heart function. It is needed for pancreatic function and tissue elasticity and has been shown to protect against radiation and toxic minerals. High levels of heart disease are associated with selenium-deficient soil in Finland and a tendency to fibrotic heart lesions is associated with selenium deficiency in parts of China. Best sources are butter, Brazil nuts, seafood and grains grown in selenium-rich soil.
Mechanism of Action of Selenium
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Pharmacokinets of Selenium
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Onset of Action for Selenium
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Duration of Action for Selenium
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Half Life of Selenium
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Side Effects of Selenium
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Contra-indications of Selenium
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Special Precautions while taking Selenium
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Selenium
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Interactions for Selenium
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Typical Dosage for Selenium
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Schedule of Selenium
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Storage Requirements for Selenium
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Effects of Missed Dosage of Selenium
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Effects of Overdose of Selenium
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