Calcium Dobesilate Pharmacology

Calcium Dobesilate

About Calcium Dobesilate
Antithrombotic, vasoprotective.
Mechanism of Action of Calcium Dobesilate
It acts on capillary and venous walls and decreases increased capillary and venous permeability and fragility and improves decreased resistance. Thus exerting an anti edematous and protective action on blood vessels. It increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase. It acts on endothelial layer and basement membrane of capillaries and decreases histamine and bradykinin induced hyperpermeability. It prevents breakdown of collagen and reduce viscosity of blood and plasma and improves blood flow & prevents stasis but accelerates type-2 collagen fibrinogenesis a major structural component of arterial wall. It exerts antiplatelet and fibrinolytic actions by inhibiting platelet activation factor and enhancing the release of tissue plasminogen activator & hence improves blood flow to tissues. It decreases platelet aggregation stimulated by collagen and thrombin and antiplatelet action counteract thrombosis. It inhibits two pathophysiological reactions in diabetes viz. polyol pathway and glycation of proteins by inhibitory effects on aldose reductase. It also inhibits formation of sorbitol.
Pharmacokinets of Calcium Dobesilate
Absorption: Well absorbed orally
Distribution: Widely distributed in to the body
Metabolism: A portion is metabolized in kidneys
Excretion: Excreted through urine and faeces
Onset of Action for Calcium Dobesilate
Duration of Action for Calcium Dobesilate
Half Life of Calcium Dobesilate
2 to 8hours
Side Effects of Calcium Dobesilate
1.Gastro intestinal irritation
Contra-indications of Calcium Dobesilate
1.Hypersensitivity to the drug
Special Precautions while taking Calcium Dobesilate
1.Renal impairment
2.Duodenal ulcer
3.Peptic ulcer
5.Allergic manifestations such as rashes, Pruritus, fever etc.
Pregnancy Related Information
May be used
First trimester: contraindicated
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Calcium Dobesilate
1.Diabetic retinopathy
2.Micro angiopathy
3.Varicose veins
5.Myocardial infarction.
Interactions for Calcium Dobesilate
Typical Dosage for Calcium Dobesilate
Diabetic retinopathy and micro angiopathy:
500mg to1000mg/day in two divided doses for 4 to 6months followed by 500mg once daily.
Varicose veins and Haemorrhoids:
500mg 12th hourly up to 3 weeks followed by 500mg once daily
Prevention of secondary myocardial infarction:
Schedule of Calcium Dobesilate
Storage Requirements for Calcium Dobesilate
Store in well closed container and protected from light and moisture. Keep out of reach of children
Effects of Missed Dosage of Calcium Dobesilate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Calcium Dobesilate
Treatment is supportive and symptomatic. Perform induced emesis and gastric lavage.

Home Delivery for Calcium Dobesilate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for calcium dobesilate and other medicines and health products. Home delivery services for calcium dobesilate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take calcium dobesilate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for calcium dobesilate before they complete the sale. You can get this information while placing the order for calcium dobesilate with the pharmacy.

Calcium Dobesilate is a generic medicine name and there are several brands available for it. Some of the brands for calcium dobesilate might be better known than calcium dobesilate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have calcium dobesilate in stock, you can ask for one of the branded alternatives for calcium dobesilate.