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- Pharmacology For Calcium Dobesilate
Calcium Dobesilate Pharmacology
Calcium DobesilateAbout Calcium DobesilateAntithrombotic, vasoprotective.Mechanism of Action of Calcium DobesilateIt acts on capillary and venous walls and decreases increased capillary and venous permeability and fragility and improves decreased resistance. Thus exerting an anti edematous and protective action on blood vessels. It increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase. It acts on endothelial layer and basement membrane of capillaries and decreases histamine and bradykinin induced hyperpermeability. It prevents breakdown of collagen and reduce viscosity of blood and plasma and improves blood flow & prevents stasis but accelerates type-2 collagen fibrinogenesis a major structural component of arterial wall. It exerts antiplatelet and fibrinolytic actions by inhibiting platelet activation factor and enhancing the release of tissue plasminogen activator & hence improves blood flow to tissues. It decreases platelet aggregation stimulated by collagen and thrombin and antiplatelet action counteract thrombosis. It inhibits two pathophysiological reactions in diabetes viz. polyol pathway and glycation of proteins by inhibitory effects on aldose reductase. It also inhibits formation of sorbitol.Pharmacokinets of Calcium DobesilateAbsorption: Well absorbed orally
Distribution: Widely distributed in to the body
Metabolism: A portion is metabolized in kidneys
Excretion: Excreted through urine and faeces
Onset of Action for Calcium DobesilateN/ADuration of Action for Calcium DobesilateN/AHalf Life of Calcium Dobesilate2 to 8hoursSide Effects of Calcium Dobesilate1.Gastro intestinal irritation
Contra-indications of Calcium Dobesilate1.Hypersensitivity to the drugSpecial Precautions while taking Calcium Dobesilate1.Renal impairment
5.Allergic manifestations such as rashes, Pruritus, fever etc.
Pregnancy Related InformationMay be used
First trimester: contraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Calcium Dobesilate1.Diabetic retinopathy
Interactions for Calcium DobesilateN/ATypical Dosage for Calcium DobesilateDiabetic retinopathy and micro angiopathy:
500mg to1000mg/day in two divided doses for 4 to 6months followed by 500mg once daily.
Varicose veins and Haemorrhoids:
500mg 12th hourly up to 3 weeks followed by 500mg once daily
Prevention of secondary myocardial infarction:
Schedule of Calcium DobesilateHStorage Requirements for Calcium DobesilateStore in well closed container and protected from light and moisture. Keep out of reach of childrenEffects of Missed Dosage of Calcium DobesilateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Calcium DobesilateTreatment is supportive and symptomatic. Perform induced emesis and gastric lavage.
Home Delivery for Calcium Dobesilate in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including calcium dobesilate.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for calcium dobesilate and other medicines and health products. Home delivery services for calcium dobesilate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take calcium dobesilate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for calcium dobesilate before they complete the sale. You can get this information while placing the order for calcium dobesilate with the pharmacy.
Calcium Dobesilate is a generic medicine name and there are several brands available for it. Some of the brands for calcium dobesilate might be better known than calcium dobesilate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have calcium dobesilate in stock, you can ask for one of the branded alternatives for calcium dobesilate.