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- Pharmacology For Calcium Dobesilate + Dioctyl Sodium Sulphosuccinate
Calcium Dobesilate + Dioctyl Sodium Sulphosuccinate Pharmacology
Calcium Dobesilate + Dioctyl Sodium SulphosuccinateAbout Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/AMechanism of Action of Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/APharmacokinets of Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/AOnset of Action for Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/ADuration of Action for Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/AHalf Life of Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/ASide Effects of Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/AContra-indications of Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/ASpecial Precautions while taking Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Calcium Dobesilate + Dioctyl Sodium Sulphosuccinate1.HaemorrhoidsInteractions for Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/ATypical Dosage for Calcium Dobesilate + Dioctyl Sodium SulphosuccinateAdult:1 tablet to be taken 2 times dailySchedule of Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/AStorage Requirements for Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/AEffects of Missed Dosage of Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/AEffects of Overdose of Calcium Dobesilate + Dioctyl Sodium SulphosuccinateN/A
Calcium DobesilateAbout Calcium DobesilateAntithrombotic, vasoprotective.Mechanism of Action of Calcium DobesilateIt acts on capillary and venous walls and decreases increased capillary and venous permeability and fragility and improves decreased resistance. Thus exerting an anti edematous and protective action on blood vessels. It increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase. It acts on endothelial layer and basement membrane of capillaries and decreases histamine and bradykinin induced hyperpermeability. It prevents breakdown of collagen and reduce viscosity of blood and plasma and improves blood flow & prevents stasis but accelerates type-2 collagen fibrinogenesis a major structural component of arterial wall. It exerts antiplatelet and fibrinolytic actions by inhibiting platelet activation factor and enhancing the release of tissue plasminogen activator & hence improves blood flow to tissues. It decreases platelet aggregation stimulated by collagen and thrombin and antiplatelet action counteract thrombosis. It inhibits two pathophysiological reactions in diabetes viz. polyol pathway and glycation of proteins by inhibitory effects on aldose reductase. It also inhibits formation of sorbitol.Pharmacokinets of Calcium DobesilateAbsorption: Well absorbed orally
Distribution: Widely distributed in to the body
Metabolism: A portion is metabolized in kidneys
Excretion: Excreted through urine and faeces
Onset of Action for Calcium DobesilateN/ADuration of Action for Calcium DobesilateN/AHalf Life of Calcium Dobesilate2 to 8hoursSide Effects of Calcium Dobesilate1.Gastro intestinal irritation
Contra-indications of Calcium Dobesilate1.Hypersensitivity to the drugSpecial Precautions while taking Calcium Dobesilate1.Renal impairment
5.Allergic manifestations such as rashes, Pruritus, fever etc.
Pregnancy Related InformationMay be used
First trimester: contraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Calcium Dobesilate1.Diabetic retinopathy
Interactions for Calcium DobesilateN/ATypical Dosage for Calcium DobesilateDiabetic retinopathy and micro angiopathy:
500mg to1000mg/day in two divided doses for 4 to 6months followed by 500mg once daily.
Varicose veins and Haemorrhoids:
500mg 12th hourly up to 3 weeks followed by 500mg once daily
Prevention of secondary myocardial infarction:
Schedule of Calcium DobesilateHStorage Requirements for Calcium DobesilateStore in well closed container and protected from light and moisture. Keep out of reach of childrenEffects of Missed Dosage of Calcium DobesilateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Calcium DobesilateTreatment is supportive and symptomatic. Perform induced emesis and gastric lavage.
Dioctyl Sodium SulphosuccinateAbout Dioctyl Sodium SulphosuccinateAnionic surface-active agent,Stool Softener, Emollient Laxative, Ceruminolytic.Mechanism of Action of Dioctyl Sodium SulphosuccinateDioctyl sodium sulfosuccinate is an emollient laxative. It is an anionic detergent that increases the miscibility of water and thereby enhancing lipid absorption and impairing water absorption. It reduces surface tension and it has no role in peristalsis but it promotes softening of faeces.
It increases mucosal cyclic AMP mediated active anion secretion and produces increased accumulation of luminal fluid and produces defecation.
Pharmacokinets of Dioctyl Sodium SulphosuccinateN/AOnset of Action for Dioctyl Sodium Sulphosuccinate1 - 2 daysDuration of Action for Dioctyl Sodium SulphosuccinateN/AHalf Life of Dioctyl Sodium SulphosuccinateN/ASide Effects of Dioctyl Sodium Sulphosuccinate1.Diarrhoea
Contra-indications of Dioctyl Sodium Sulphosuccinate1.Hypersensitivity to the drug
Special Precautions while taking Dioctyl Sodium Sulphosuccinate1.Prolonged use of this medicine
2.People with nausea, vomiting or persistant abdominal pain.
3.People with a blockage in the gut (intestinal obstruction).
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 12 years: ContraindicatedIndications for Dioctyl Sodium Sulphosuccinate1.Chronic constipation.
2.Softening stools in people with haemorrhoids (piles) or anal fissure
Interactions for Dioctyl Sodium SulphosuccinateN/ATypical Dosage for Dioctyl Sodium Sulphosuccinate100 - 200 mg 3 times a day Schedule of Dioctyl Sodium SulphosuccinateN/AStorage Requirements for Dioctyl Sodium SulphosuccinateStore at 15 - 30 degree C. Protect from heat and light. Kept the container tightly closed after use. Keep out of the reach of childrenEffects of Missed Dosage of Dioctyl Sodium SulphosuccinateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dioctyl Sodium SulphosuccinateGive supportive measures and symptomatic treatment.
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Calcium Dobesilate + Dioctyl Sodium Sulphosuccinate is a generic medicine name and there are several brands available for it. Some of the brands for calcium dobesilate + dioctyl sodium sulphosuccinate might be better known than calcium dobesilate + dioctyl sodium sulphosuccinate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have calcium dobesilate + dioctyl sodium sulphosuccinate in stock, you can ask for one of the branded alternatives for calcium dobesilate + dioctyl sodium sulphosuccinate.