Pancuronium Pharmacology


About Pancuronium
Nicotinic antagonist,Long acting Nondepolarizing Neuromuscular Blocker, Skeletal Muscle Relaxant.
Mechanism of Action of Pancuronium
This bis-quaternary ammonium steroid is a non-depolarizing neuromuscular blocking agent that competes with acetylcholine for cholino- ceptive sites at the postjunctional membrane and thereby blocks competitively the transmitter action of acetylcholine resulting in muscle paralysis. It can also release histamine in the body.
General anaesthesia: It is often administered during the induction of anaesthesia to relax muscles of the jaw, neck and airway and thereby facilitate laryngoscopy and endotracheal intubation. Following induction, continued muscle relaxation is required for many procedures to aid surgical exposure and to provide additional insurance of immobility.
Pharmacokinets of Pancuronium
Absorption- Rapidly absorbed after intravenous administration.
Distribution- Widely distributed in the body as plasma protein bounded (77 to 91%) form.
Metabolism- Metabolized in the liver.
Excretion- Excreted through urine (unchanged form) and bile.
Onset of Action for Pancuronium
3-5 minutes after intravenous administration
Duration of Action for Pancuronium
45-60 minutes
Half Life of Pancuronium
Side Effects of Pancuronium
1. Transient hypotension
2. Tachycardia
3. Dysrhythmias
4. Increased blood pressure
5. Excessive salivation
6. Pain and burning at the injection site
Contra-indications of Pancuronium
1. Hypersensitivity to the drug or any ingredients of it
2. Inability to control airway and/or support ventilations with oxygen and positive pressure
3. Neuromuscular diseases (e.g. Myasthenia gravis)
Special Precautions while taking Pancuronium
1. Artificial respiration with intermittent positive pressure ventilation
2. Myasthenia gravis
3. Renal impairment
4. Hepatic impairment
5. Pulmonary function impairment
6. Biliary tract disease
7. Severe obesity
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Pancuronium
1. Induction or maintenance of paralysis after intubation to assist ventilations
2. Maintenance of muscle relaxation in patients undergoing mechanical ventilation
Interactions for Pancuronium
Antibiotics: Aminoglycosides, Tetracyclines, Bacitracin, Polymyxin B, Clindamycin, Lincomycin & Colistin: Parenteral doses of these antibiotics used pre-operatively may produce unexpected prolongation of neuromuscular blockade.
Azathioprine: Causes reversal of neuromuscular blocking effect of pancuronium.
Inhalation anaesthetics (Halothane, Enflurane, Isoflurane): Potentiation of neuromuscular blockade.
Magnesium Sulphate: Neuromuscular blockade of pancuronium enhanced.
Other neuromuscular blocking agents: (e.g. tubocuraine): Synergistic effect though the blockade is not prolonged.
Quinine: Effects of pancuronium enhanced.
Succinylcholine: Prior administration enhances the relaxant effect of pancuronium and its duration of action.
Theophylline: The effect of pancuronium may be reversed. Chances of cardiac arrhythmias.
Typical Dosage for Pancuronium
0.1 mg/kg slow IV; repeat every 30-60 minutes as needed.
0.04 - 0.1 mg/kg slow IV push (newborn: 0.02 mg/kg )
Schedule of Pancuronium
Storage Requirements for Pancuronium
Store at 2?C - 8?C.Do not freeze.
Effects of Missed Dosage of Pancuronium
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Pancuronium
Give symptomatic and supportive treatment. Administer atropine and neostigmine for the reversal of neuromuscular action of pancuronium.

Home Delivery for Pancuronium in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pancuronium.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pancuronium and other medicines and health products. Home delivery services for pancuronium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take pancuronium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pancuronium before they complete the sale. You can get this information while placing the order for pancuronium with the pharmacy.

Pancuronium is a generic medicine name and there are several brands available for it. Some of the brands for pancuronium might be better known than pancuronium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pancuronium in stock, you can ask for one of the branded alternatives for pancuronium.