Zopiclone Pharmacology


About Zopiclone
A non-benzodiazepine, a cyclopyrrolone derivative, Hypnotic,Sedative.
Mechanism of Action of Zopiclone
Zopiclone is a non benzodiazepine sedative hypnotic drug. It has agonistic action on omega1 binding site of alpha1 GABA-A receptor subunit. Zopiclone potentiates the action of GABA and decreases firing rate of neurons. This will produce a sedative-hypnotic effect.
Pharmacokinets of Zopiclone
Absorption: It is rapidly absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes metabolism in the liver.
Excretion: it is excreted mainly through urine. Small amount of the drug is also excreted through faeces and breast milk
Onset of Action for Zopiclone
1.5 - 2 hours
Duration of Action for Zopiclone
Half Life of Zopiclone
3. 5 - 6.5 hours
Side Effects of Zopiclone
1. Bitter taste
2. Nausea
3. Vomiting
4. Drowsiness
5. Headache
6. Incoordination
7. Amnesia
8. Hallucinations
9. Behavioural disturbances
10. Hypersensitivity reactions
Contra-indications of Zopiclone
1. Hypersensitivity to Zopiclone
2. Myasthenia gravis
Special Precautions while taking Zopiclone
1. Renal impairment
2. Hepatic impairment
3. Use caution while driving vehicles or operating machines or involved in any dangerous activities
4. Alcoholics
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES : Contraindicated
Indications for Zopiclone
1. Insomnia
Interactions for Zopiclone
Metoclopramide: Concomitant administration may increase the plasma concentration of zopiclone.
Atropine: May decrease its plasma concentration, when given concurrently.
Trimipramine: If given along with Zopiclone may result in lessened antidepressant effect of the former.
Typical Dosage for Zopiclone
7.5 mg at night
Schedule of Zopiclone
Storage Requirements for Zopiclone
Store at 15 - 30 degree C in a dry place. Protect from light. Keep out of the reach of children.
Effects of Missed Dosage of Zopiclone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Zopiclone
Give supportive measures and symptomatic treatment. Gastric lavage can be done if the ingestion is recent. Flumazenil can be given as antagonist. Treat hypotension with IV fluids.

Home Delivery for Zopiclone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including zopiclone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for zopiclone and other medicines and health products. Home delivery services for zopiclone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take zopiclone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for zopiclone before they complete the sale. You can get this information while placing the order for zopiclone with the pharmacy.

Zopiclone is a generic medicine name and there are several brands available for it. Some of the brands for zopiclone might be better known than zopiclone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have zopiclone in stock, you can ask for one of the branded alternatives for zopiclone.