Zolpidem Pharmacology


About Zolpidem
Nonbenzodiazepine, Imidazopyridine derivative, Sedative-hypnotic(treatment of insomnia), Anxiolytic.
Mechanism of Action of Zolpidem
Zolpidem is a non benzodiazepine sedative hypnotic drug. It has agonistic action on omega1 binding site on alpha-1 GABA-A receptor subunit which is important in mediating hypnotic effect.
Pharmacokinets of Zolpidem
Absorption: It is rapidly absorbed after oral administration.
Distribution: It is distributed in protein bound form.
Metabolism: It is metabolised in the liver to inactive metabolite.
Excretion: It is excreted mainly in urine
Onset of Action for Zolpidem
15 minutes
Duration of Action for Zolpidem
Half Life of Zolpidem
2 hours
Side Effects of Zolpidem
1. Drowsiness
2. Dizziness
3. Light headedness
4. Headache
5. Amnesia
6. Hangover
7. Depression
8. Lethargy
9. Palpitation
10. Dry mouth
11. Nausea
12. Vomiting
13. Diarrhoea
14. Rash
Contra-indications of Zolpidem
Special Precautions while taking Zolpidem
1. Renal impairment
2. Hepatic impairment
3. Alcoholics
4. Depression
5. Drug abuse
6. Driving vehicles, operating machines or involved in any dangerous activities
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES : Contraindicated
Indications for Zolpidem
1. Insomnia
Interactions for Zolpidem
Imipramine, Chlorpromazine: There is an additive effect of decreased alertness, psychomotor performance.
Flumazenil: The drug`s sedative/hypnotic effects are reversed by flumazenil..
Typical Dosage for Zolpidem
10 mg at bed time
Schedule of Zolpidem
Storage Requirements for Zolpidem
Store at 20 - 25 degree C.
Effects of Missed Dosage of Zolpidem
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Zolpidem
Give symptomatic treatment and supportive measures. Gastric lavage has to be done. Flumazenil can be given as antagonist. Treat hypotension with IV fluids.

Home Delivery for Zolpidem in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including zolpidem.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for zolpidem and other medicines and health products. Home delivery services for zolpidem may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take zolpidem only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for zolpidem before they complete the sale. You can get this information while placing the order for zolpidem with the pharmacy.

Zolpidem is a generic medicine name and there are several brands available for it. Some of the brands for zolpidem might be better known than zolpidem itself. If the pharmacy that's willing to deliver medicines to your home doesn't have zolpidem in stock, you can ask for one of the branded alternatives for zolpidem.