Doxapram Pharmacology


About Doxapram
Pyrrolidone derivative,Morpholine derivative, CNS stimulant, Respiratory stimulant.
Mechanism of Action of Doxapram
Doxapram acts by promoting excitation of central neurons. It produces respiratory stimulation by an action on peripheral carotid and aortic body chemoreceptors. As the dose is increased Doxapram stimulates respiratory centers in the medulla and other parts of brain. The respiratory stimulant action is manifested by an increase in tidal volume with a slight increase in respiratory rate.
Pharmacokinets of Doxapram
Absorption: Doxapram is well absorbed after IV / IM administration. Distribution: It is very widely distributed throughout the body. Metabolism: Doxapram is metabolised in the liver. Excretion: Drug is excreted mainly in faeces and small amount in urine also.
Onset of Action for Doxapram
20 - 40 seconds
Duration of Action for Doxapram
5-12 minutes.
Half Life of Doxapram
4 - 12 hours
Side Effects of Doxapram
1. Headache
2. Dizziness
3. Nausea
4. Vomiting
5. Diarrhoea
6. Seizure
7. Chest pain
8. Heart rate variation
9. Hypertension
10. Laryngospasm
11. Sneezing
12. Urine retention
13. Bronchospasm
14. Hiccups
15. Pruritis
16. Hyperactivity
Contra-indications of Doxapram
1. Hypersensitivity to Doxapram
2. Heart failure
3. Hypertension
4. Seizure
5. Head injury
6. Dyspnea
7. Pulmonary embolism
8. Pneumothorax
9. Obstructed air way
10. Acute bronchial asthma
11. Muscle paresis
12. Flail chest
13. Head injury
Special Precautions while taking Doxapram
1. Hepatic impairment
2. Heart diseases
3. Obstructive air way disease
Pregnancy Related Information
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution.
CHILDREN below 12 years: contraindicated
Indications for Doxapram
1. Post anaesthesia respiratory stimulation
2. Drug induced CNS depression
3. Acute respiratory failure
Interactions for Doxapram
Sympathomimetics or MAOIs: Additive pressor effects.
Halothane, Cyclopropane & Enflurane: Delay initiation of therapy for at least 10 minutes following discontinuation of anaesthetics.
Muscle Relaxants: May mask residual effects of muscle relaxants.
Theophylline: Agitation, muscle fasciculation and hyperactivity.
Morphine: Antagonises morphine induced respiratory depression.
Alkaline solutions like Aminophylline, Frusemide & Thiopentone: Precipitation occurs.
Typical Dosage for Doxapram
Post anaesthesia respiratory stimulation as IV: 0.5 - 1 mg / kg body weight if necessary repeat after 1 hour
Drug induced CNS depression: Initial dose IV injection: 2 mg / kg body weight if necessary repeat after 5 minutes and again 1 - 2 hour until patient awakens.
Maximum daily dose: 3 g
Acute respiratory failure IV infusion: 1.5 - 4 mg / minute
Schedule of Doxapram
Storage Requirements for Doxapram
Reconstituted solution is store at 15 - 30 degree C and it is stable for only 2 days. Do not freeze the solution. Keep out of the reach of children.
Effects of Missed Dosage of Doxapram
Dosage is decided by healthcare professionals.
Effects of Overdose of Doxapram
Give supportive measures and symptomatic treatment.

Home Delivery for Doxapram in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including doxapram.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for doxapram and other medicines and health products. Home delivery services for doxapram may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take doxapram only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for doxapram before they complete the sale. You can get this information while placing the order for doxapram with the pharmacy.

Doxapram is a generic medicine name and there are several brands available for it. Some of the brands for doxapram might be better known than doxapram itself. If the pharmacy that's willing to deliver medicines to your home doesn't have doxapram in stock, you can ask for one of the branded alternatives for doxapram.