Zaleplon Pharmacology


About Zaleplon
Pyrazolopyrimidine derivative( a nonbenzodiazepine, Sedative-hypnotic.
Mechanism of Action of Zaleplon
Zaleplon is a non benzodiazepine sedative-hypnotic drug. It binds to the benzodiazepine binding site on GABA-A receptors containing the alpha 1 receptor sub unit and alters the GABA mediated chloride channel opening. This is responsible for sedative effect of the drug.
Pharmacokinets of Zaleplon
Absorption: It is rapidly absorbed after oral administration.
Distribution: It is distributed in protein bound form (60%).
Metabolism: It is metabolised in the liver to inactive metabolite.
Excretion: It is excreted mainly in urine

Onset of Action for Zaleplon
Duration of Action for Zaleplon
Half Life of Zaleplon
1 hour
Side Effects of Zaleplon
1. Amnesia
2. Dizziness
3. Light headedness
4. Headache
5. Somnolence
6. Hallucinations
7. Depression
8. Vertigo
9. Palpitation
10. Dry mouth
11. Nausea
12. Vomiting
13. Diarrhoea
14. Rash
15. Lack of concentrations
16. Paresthesia
Contra-indications of Zaleplon
1. severe hepatic impairment
2. Hypersensitivity to Zaleplon
Special Precautions while taking Zaleplon
2. Debilitated patients
3. Hepatic impairment
4. Severe renal impairment
5. Alcoholics
6. Depression
7. Drug abuse
8. Driving vehicles, operating machines or involved in any dangerous activities.
Pregnancy Related Information

Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Zaleplon
Interactions for Zaleplon
Rifampin: It reduces the AUC of zaleplon.
Cimetidine: It increases the Cmax and AUC of zaleplon.
Food: If zaleplon is taken with or immediately after fatty meal its effect on sleep onset may be reduced.
Typical Dosage for Zaleplon
10 mg at bed time
Schedule of Zaleplon
Storage Requirements for Zaleplon
Store at 20 - 25 degree C. Keep out of the reach of children.
Effects of Missed Dosage of Zaleplon
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Zaleplon
Give supportive measures and symptomatic treatment. Gastric lavage has to be done to remove the drug.

Home Delivery for Zaleplon in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including zaleplon.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for zaleplon and other medicines and health products. Home delivery services for zaleplon may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take zaleplon only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for zaleplon before they complete the sale. You can get this information while placing the order for zaleplon with the pharmacy.

Zaleplon is a generic medicine name and there are several brands available for it. Some of the brands for zaleplon might be better known than zaleplon itself. If the pharmacy that's willing to deliver medicines to your home doesn't have zaleplon in stock, you can ask for one of the branded alternatives for zaleplon.