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- Pharmacology For Melatonin + Vit B6
Melatonin + Vit B6 Pharmacology
Melatonin + Vit B6About Melatonin + Vit B6N/AMechanism of Action of Melatonin + Vit B6N/APharmacokinets of Melatonin + Vit B6N/AOnset of Action for Melatonin + Vit B6N/ADuration of Action for Melatonin + Vit B6N/AHalf Life of Melatonin + Vit B6N/ASide Effects of Melatonin + Vit B6N/AContra-indications of Melatonin + Vit B6N/ASpecial Precautions while taking Melatonin + Vit B6N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Melatonin + Vit B6N/AInteractions for Melatonin + Vit B6N/ATypical Dosage for Melatonin + Vit B6N/ASchedule of Melatonin + Vit B6N/AStorage Requirements for Melatonin + Vit B6N/AEffects of Missed Dosage of Melatonin + Vit B6N/AEffects of Overdose of Melatonin + Vit B6N/A
MelatoninAbout MelatoninA naturally occurring hormone from pineal gland, In Sleep Disorders, dietary supplement.Mechanism of Action of MelatoninMelatonin is the hormone secreted by the pineal gland. Melatonin synthesis displays circadian rhythm. The rhythm is generalised by a circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Light signals enter through a direct retinal pathway to the suprachiasmatic nucleus and this SCN sends circadian signals over a neural pathway to the pineal gland and regulate the synthesis of Melatonin. Synthesis and release of Melatonin are stimulated by darkness and inhibited by light. Melatonin receptor ML1 belongs to G-protein coupled receptors. Melatonin binds to this receptor and inhibit adenylate cyclase enzyme. Melatonin affect sleep pattern. Because of its possible role in influencing circadian rhythm, melatonin has been tried in the alleviation of jet lag and other disorders resulting from delay of sleep. This action is responsible for the management of insomniaPharmacokinets of MelatoninAbsorption: It is rapidly absorbed after oral administration. Metabolism: It is metabolised in the liver. Excretion: It is excreted mainly through urine.Onset of Action for MelatoninN/ADuration of Action for Melatonin30 minutesHalf Life of Melatonin45 - 60 minutesSide Effects of Melatonin1.Gastric upset
8.Increased prolactin level
9.Decreased Luteinizing levelContra-indications of Melatonin1.Cardiovascular disorder
5.Steroid taking patients
8.AlcoholicsSpecial Precautions while taking MelatoninUse with caution while driving vehicle or operate machines or involved in any hazardous activities because Melatonin cause drowsiness.Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationContraindicated
Indications for MelatoninInsomnia-abolishes symptom of jet-lagInteractions for MelatoninN/ATypical Dosage for Melatonin3 mg / day; the drug should be taken at night.Schedule of MelatoninN/AStorage Requirements for MelatoninStore at room temperature in a tightly closed container.Effects of Missed Dosage of MelatoninDo not apply.Effects of Overdose of MelatoninGive supportive measures and symptomatic treatment.
Vit B6About Vit B6Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.Mechanism of Action of Vit B6Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.Pharmacokinets of Vit B6Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver
Onset of Action for Vit B6N/ADuration of Action for Vit B6N/AHalf Life of Vit B615-20 daysSide Effects of Vit B61. Neuropathy
2. Unstable gait
4. Perioral numbness
6. Numbness of feet
8. Sensory neuropathy
Contra-indications of Vit B61. Hypersensitivity to Vitamin B6Special Precautions while taking Vit B6N/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Indications for Vit B61. Vitamin B6 deficiency including inadequate diet and drug induced causes
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning
Interactions for Vit B6Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.
Typical Dosage for Vit B6Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.
Schedule of Vit B6N/AStorage Requirements for Vit B6Store it at 15 - 30 degree C. Protect from moisture and heat.Effects of Missed Dosage of Vit B6Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B6Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.
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