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- Pharmacology For Alprazolam + Melatonin
Alprazolam + Melatonin Pharmacology
Alprazolam + Melatonin
About Alprazolam + MelatoninN/AMechanism of Action of Alprazolam + MelatoninN/APharmacokinets of Alprazolam + MelatoninN/AOnset of Action for Alprazolam + MelatoninN/ADuration of Action for Alprazolam + MelatoninN/AHalf Life of Alprazolam + MelatoninN/ASide Effects of Alprazolam + MelatoninN/AContra-indications of Alprazolam + MelatoninN/ASpecial Precautions while taking Alprazolam + MelatoninN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Alprazolam + MelatoninSleep disordersInteractions for Alprazolam + MelatoninN/ATypical Dosage for Alprazolam + MelatoninAdult: 1 tablet to be taken at night.
Following combinations are available
Alprazolam 0.25 mg + Melatonin 3 mg and
Alprazolam 0.5 mg + Melatonin 3 mg
Schedule of Alprazolam + MelatoninN/AStorage Requirements for Alprazolam + MelatoninN/AEffects of Missed Dosage of Alprazolam + MelatoninN/AEffects of Overdose of Alprazolam + MelatoninN/AAlprazolam
About AlprazolamBenzodiazepine derivative, Anti anxiety.Mechanism of Action of AlprazolamAlprazolam mainly acts on Limbic system and ascending reticular formation in the CNS and binds to the BZD receptor. The binding will facilitates GABA mediated chloride channel opening and produce hyperpolarisation. This will produce an increase in the concentration of the inhibitory neurotransmitter GABA and increase in chloride ions and decreases firing rate of neuron. This in turn alters normal functions of the body.Pharmacokinets of AlprazolamAbsorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised to active and inactive metabolite in the liver. Excretion: Drug is excreted in urine.Onset of Action for Alprazolam15 - 30 minutesDuration of Action for Alprazolam12 - 16 hoursHalf Life of Alprazolam12 -15 hoursSide Effects of Alprazolam1.Ataxia
2.Drowsiness
3.Light headedness
4. Slurred speech
5.Nausea
6.Constipation or diarrhoea
7.Tremor
8.Dependence
9.Anorexia
0.Confusion
11.Light headedness
12.Mood changes
13.Muscle rigidity
14.AmnesiaContra-indications of Alprazolam1.Hypersensitivity to Benzodiazepines
2.Acute angle closure glaucomaSpecial Precautions while taking Alprazolam1.Renal impairment
2.Hepatic impairment
3.Pulmonary insufficiency
4.Drug abuse
5.Bipolar disorder
6.Driving vehicles and operating machines and people involving any other dangerous activitiesPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES- contraindicated
Indications for Alprazolam1.For the short-term management of anxiety,
2.Treatment of Panic disorder.Interactions for AlprazolamAlcohol & other CNS depressants: Enhanced CNS effects.
Aminophylline: Antagonizes the sedative effect.
Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranolol,
Valproic Acid: Elimination of alprazolam decreased due to inhibition of hepatic metabolism leading to enhanced activity.
Digoxin: Increase in serum concentration of Digoxin.
Imipramine & Desipramine: Enhanced activity of these drugs.
Levodopa: Decrease in antiparkinsonism efficacy.
Rifampicine: Decreases efficacy.Typical Dosage for AlprazolamAdult:
Anxiety: 0.25 - 0.5 mg every 8 hours in a day. Depending on the severity of the disease the dose can be gradually increased every 3 or 4 days.
Maximum dose: 4 mg / day in divided dose.
Anxiety with depression: 0.5 mg every 8 hours in a day
Maintenance dose: 1.5 - 4.5 mg/ day in divided dose
Panic disorder: starting dose: 1.5 mg /day in 3 divided dose. Depending on the severity of the disease the dose can be gradually increased every 3 or 4 days.
Children: Not recommended
Schedule of AlprazolamHStorage Requirements for AlprazolamThe drug should be kept at 15 - 30 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of AlprazolamTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of AlprazolamGive supportive measures and symptomatic treatment. Flumazenil can be given as antagonist. Hypotension can be treated with vasopressors.If the patient is conscious induce emesis followed by charcoal administrationMelatonin
About MelatoninA naturally occurring hormone from pineal gland, In Sleep Disorders, dietary supplement.Mechanism of Action of MelatoninMelatonin is the hormone secreted by the pineal gland. Melatonin synthesis displays circadian rhythm. The rhythm is generalised by a circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Light signals enter through a direct retinal pathway to the suprachiasmatic nucleus and this SCN sends circadian signals over a neural pathway to the pineal gland and regulate the synthesis of Melatonin. Synthesis and release of Melatonin are stimulated by darkness and inhibited by light. Melatonin receptor ML1 belongs to G-protein coupled receptors. Melatonin binds to this receptor and inhibit adenylate cyclase enzyme. Melatonin affect sleep pattern. Because of its possible role in influencing circadian rhythm, melatonin has been tried in the alleviation of jet lag and other disorders resulting from delay of sleep. This action is responsible for the management of insomniaPharmacokinets of MelatoninAbsorption: It is rapidly absorbed after oral administration. Metabolism: It is metabolised in the liver. Excretion: It is excreted mainly through urine.Onset of Action for MelatoninN/ADuration of Action for Melatonin30 minutesHalf Life of Melatonin45 - 60 minutesSide Effects of Melatonin1.Gastric upset
2.Hangover effect
3.Headache
4.Lethargy
5.Amnesia
6.Drowsiness
7.Hypothermia
8.Increased prolactin level
9.Decreased Luteinizing levelContra-indications of Melatonin1.Cardiovascular disorder
2.Mental illness
3.Allergies
4.Autoimmune disease
5.Steroid taking patients
6.Immunosuppression
7.Epilepsy
8.AlcoholicsSpecial Precautions while taking MelatoninUse with caution while driving vehicle or operate machines or involved in any hazardous activities because Melatonin cause drowsiness.Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationContraindicated
NEONATES: contraindicated
Indications for MelatoninInsomnia-abolishes symptom of jet-lagInteractions for MelatoninN/ATypical Dosage for Melatonin3 mg / day; the drug should be taken at night.Schedule of MelatoninN/AStorage Requirements for MelatoninStore at room temperature in a tightly closed container.Effects of Missed Dosage of MelatoninDo not apply.Effects of Overdose of MelatoninGive supportive measures and symptomatic treatment.Home Delivery for Alprazolam + Melatonin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including alprazolam + melatonin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for alprazolam + melatonin and other medicines and health products. Home delivery services for alprazolam + melatonin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take alprazolam + melatonin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for alprazolam + melatonin before they complete the sale. You can get this information while placing the order for alprazolam + melatonin with the pharmacy.
Alprazolam + Melatonin is a generic medicine name and there are several brands available for it. Some of the brands for alprazolam + melatonin might be better known than alprazolam + melatonin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have alprazolam + melatonin in stock, you can ask for one of the branded alternatives for alprazolam + melatonin.
