Chlordiazepoxide Pharmacology


About Chlordiazepoxide
Benzodiazepine derivative, Sedative /hypnotic, Antianxiety and skeletal muscle relaxant.
Mechanism of Action of Chlordiazepoxide
Chlordiazepoxide mainly acts on Limbic system and ascending reticular formation in the CNS. It binds to the BZD receptor. The binding will facilitates GABA mediated chloride channel opening and produce hyperpolarisation. This will increase the concentration of inhibitory neurotransmitter GABA and chloride ions in the CNS and decreases firing rate of neurons. This in turn alters normal excitatory functions of the body.
Pharmacokinets of Chlordiazepoxide
Absorption: It is absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It is metabolised to active metabolite in the liver. Excretion: Most metabolites are excreted through urine
Onset of Action for Chlordiazepoxide
1 - 2 hour
Duration of Action for Chlordiazepoxide
12 - 24 hour
Half Life of Chlordiazepoxide
5 - 30 hour
Side Effects of Chlordiazepoxide
9.Pain at the site of injection
12.Mood changes
Contra-indications of Chlordiazepoxide
Hypersensitivity to Benzodiazepines
Special Precautions while taking Chlordiazepoxide
1.Renal impairment
2.Hepatic impairment
3.Myasthenia gravis
4.Respiratory disease
6.Use caution while driving vehicles, operating machines or other dangerous activities
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
children < 6 years: contraindicated
NEONATES- contraindicated
Indications for Chlordiazepoxide
1. Anxiety
2.Treatment of alcohol withdrawal symptom
3. Insomnia
4. Pre and post operative apprehension
Interactions for Chlordiazepoxide
Alcohol & Other CNS Depressants: Enhanced CNS effects.
Aminophylline: Antagonizes the sedative effect.
Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranolol.
Valproic acid: Elimination of chlordiazepoxide decreased due to inhibition of hepatic metabolism leading to enhanced activity.
Digoxin: Increase in serum concentration of Digoxin.
Imipramine & Desipramine: Enhanced activity of these drugs.
Levodopa : Decrease in antiparkinsonism efficacy.
Morphine, Pethidine, Atropine and Magnesium trisilicate: Absorption of chlordiazepoxide is impaired.
Probenecid: May cause rapid onset or prolonged effect.
Rifampicin: Decreases efficacy.
Typical Dosage for Chlordiazepoxide
Adults: 5 - 10 mg 3 - 4 times daily
Severe anxiety: 20 - 25 mg 3 - 4 times daily
Treatment of alcohol withdrawal symptom: 25 - 100 mg daily; Depending on the patient`s condition dose can be reduced after 2 - 3 weeks
Pre and post operative apprehension: 5 - 10 mg 3 - 4 times daily; the drug should be given one day before surgery in pre operative apprehension
Children: 5mg 3 - 4 times daily.
Schedule of Chlordiazepoxide
Storage Requirements for Chlordiazepoxide
Store at temperature 15 - 30 degree C.Protect from light and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Chlordiazepoxide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Chlordiazepoxide
Give support and symptomatic treatment. Induce emesis or gastric lavage has to be done followed by charcoal administration. Flumazenil can be given as antagonist.

Home Delivery for Chlordiazepoxide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including chlordiazepoxide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for chlordiazepoxide and other medicines and health products. Home delivery services for chlordiazepoxide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take chlordiazepoxide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for chlordiazepoxide before they complete the sale. You can get this information while placing the order for chlordiazepoxide with the pharmacy.

Chlordiazepoxide is a generic medicine name and there are several brands available for it. Some of the brands for chlordiazepoxide might be better known than chlordiazepoxide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have chlordiazepoxide in stock, you can ask for one of the branded alternatives for chlordiazepoxide.