- Medicine India
- Generic Medicines
- A
- Pharmacology For Alprazolam + Paracetamol
Alprazolam + Paracetamol Pharmacology
Alprazolam + Paracetamol
About Alprazolam + ParacetamolN/AMechanism of Action of Alprazolam + ParacetamolN/APharmacokinets of Alprazolam + ParacetamolN/AOnset of Action for Alprazolam + ParacetamolN/ADuration of Action for Alprazolam + ParacetamolN/AHalf Life of Alprazolam + ParacetamolN/ASide Effects of Alprazolam + ParacetamolN/AContra-indications of Alprazolam + ParacetamolN/ASpecial Precautions while taking Alprazolam + ParacetamolN/APregnancy Related InformationContraindicated,since Alprazolam is contraindicated in pregnancyOld Age Related InformationN/ABreast Feeding Related InformationContraindicated,since Alprazolam is contraindicated in pregnancyChildren Related InformationN/AIndications for Alprazolam + ParacetamolAnxiety, agitation or tensionInteractions for Alprazolam + ParacetamolN/ATypical Dosage for Alprazolam + ParacetamolVaries with weight and severity of the disease.The dosage has to be decided by the treating specialist?
Alprazolam: 0.25mg
Paracetamol: 500mg
Schedule of Alprazolam + ParacetamolN/AStorage Requirements for Alprazolam + ParacetamolN/AEffects of Missed Dosage of Alprazolam + ParacetamolN/AEffects of Overdose of Alprazolam + ParacetamolN/AAlprazolam
About AlprazolamBenzodiazepine derivative, Anti anxiety.Mechanism of Action of AlprazolamAlprazolam mainly acts on Limbic system and ascending reticular formation in the CNS and binds to the BZD receptor. The binding will facilitates GABA mediated chloride channel opening and produce hyperpolarisation. This will produce an increase in the concentration of the inhibitory neurotransmitter GABA and increase in chloride ions and decreases firing rate of neuron. This in turn alters normal functions of the body.Pharmacokinets of AlprazolamAbsorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised to active and inactive metabolite in the liver. Excretion: Drug is excreted in urine.Onset of Action for Alprazolam15 - 30 minutesDuration of Action for Alprazolam12 - 16 hoursHalf Life of Alprazolam12 -15 hoursSide Effects of Alprazolam1.Ataxia
2.Drowsiness
3.Light headedness
4. Slurred speech
5.Nausea
6.Constipation or diarrhoea
7.Tremor
8.Dependence
9.Anorexia
0.Confusion
11.Light headedness
12.Mood changes
13.Muscle rigidity
14.AmnesiaContra-indications of Alprazolam1.Hypersensitivity to Benzodiazepines
2.Acute angle closure glaucomaSpecial Precautions while taking Alprazolam1.Renal impairment
2.Hepatic impairment
3.Pulmonary insufficiency
4.Drug abuse
5.Bipolar disorder
6.Driving vehicles and operating machines and people involving any other dangerous activitiesPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES- contraindicated
Indications for Alprazolam1.For the short-term management of anxiety,
2.Treatment of Panic disorder.Interactions for AlprazolamAlcohol & other CNS depressants: Enhanced CNS effects.
Aminophylline: Antagonizes the sedative effect.
Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranolol,
Valproic Acid: Elimination of alprazolam decreased due to inhibition of hepatic metabolism leading to enhanced activity.
Digoxin: Increase in serum concentration of Digoxin.
Imipramine & Desipramine: Enhanced activity of these drugs.
Levodopa: Decrease in antiparkinsonism efficacy.
Rifampicine: Decreases efficacy.Typical Dosage for AlprazolamAdult:
Anxiety: 0.25 - 0.5 mg every 8 hours in a day. Depending on the severity of the disease the dose can be gradually increased every 3 or 4 days.
Maximum dose: 4 mg / day in divided dose.
Anxiety with depression: 0.5 mg every 8 hours in a day
Maintenance dose: 1.5 - 4.5 mg/ day in divided dose
Panic disorder: starting dose: 1.5 mg /day in 3 divided dose. Depending on the severity of the disease the dose can be gradually increased every 3 or 4 days.
Children: Not recommended
Schedule of AlprazolamHStorage Requirements for AlprazolamThe drug should be kept at 15 - 30 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of AlprazolamTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of AlprazolamGive supportive measures and symptomatic treatment. Flumazenil can be given as antagonist. Hypotension can be treated with vasopressors.If the patient is conscious induce emesis followed by charcoal administrationParacetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Alprazolam + Paracetamol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including alprazolam + paracetamol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for alprazolam + paracetamol and other medicines and health products. Home delivery services for alprazolam + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take alprazolam + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for alprazolam + paracetamol before they complete the sale. You can get this information while placing the order for alprazolam + paracetamol with the pharmacy.
Alprazolam + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for alprazolam + paracetamol might be better known than alprazolam + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have alprazolam + paracetamol in stock, you can ask for one of the branded alternatives for alprazolam + paracetamol.
