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- Pharmacology For Buspirone
BuspironeAbout BuspironePsychotropic drug, serotonin 5-HT1A receptor partial agonist, weak Dopamine (D2) antagonist azaspirodecanediones derivative, Sedative, anxiolytic agent.Mechanism of Action of BuspironeBuspirone has a partial agonistic action on 5HT1A receptor and it stimulates presynaptic autoreceptors. This will produce a decrease in serotonin neuronal activity. It also has antagonistic action on post synaptic 5HT1A receptor. Buspirone has a weak Dopamine (D2) antagonistic action. Mood elevation may be due to facilitation of noradrenergic system.Pharmacokinets of BuspironeAbsorption: it is well absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted mainly in the urine and also through faeces.Onset of Action for Buspirone15 - 30 minutesDuration of Action for Buspirone6 - 8 hoursHalf Life of Buspirone2 - 3 hourSide Effects of Buspirone1.Drowsiness
16.PalpitationsContra-indications of Buspirone1.Hypersensitivity to Buspirone
3.Severe hepatic impairment
4.Severe kidney dysfunctionSpecial Precautions while taking Buspirone1.Hepatic disease
2.Renal disease, Alcoholics
3.Therapy with an MAO inhibitor.Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
Indications for BuspironeAnxietyInteractions for BuspironeAlcohol : Though it does not increase alcohol induced impairment in motor and mental performance, still concomitant use should be avoided.
Digoxin : Slight increase in serum digoxin levels causing toxicity.
Haloperidol : Enhanced serum haloperidol concentrations.
MAOIs: Concomitant use avoided because of elevation of blood pressure.Typical Dosage for BuspironeAdult: 15 - 30 mg / day in 3 divided dose
Initial dose: 15 mg / day in 3 divided dose. Dose can be gradually increased in every 3 days. Maximum daily dose: 60 mg / day
Schedule of BuspironeHStorage Requirements for BuspironeStore at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of BuspironeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Continue the regular schedule.Effects of Overdose of BuspironeGive symptomatic treatment and supportive measures. Gastric lavage has to be done.
Home Delivery for Buspirone in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including buspirone.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for buspirone and other medicines and health products. Home delivery services for buspirone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take buspirone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for buspirone before they complete the sale. You can get this information while placing the order for buspirone with the pharmacy.
Buspirone is a generic medicine name and there are several brands available for it. Some of the brands for buspirone might be better known than buspirone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have buspirone in stock, you can ask for one of the branded alternatives for buspirone.