Trimipramine Pharmacology

Trimipramine

About Trimipramine
Tricyclic Antidepressant (Tertiary Amine), Antidepressant.
Mechanism of Action of Trimipramine
Trimipramine acts by inhibiting the re-uptake of Noradrenaline and Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitters in the synaptic cleft and produces antidepressant effect. Trimipramine more selectively inhibit the reuptake of Noradrenaline than Serotonin. Trimipramine also has anticholinergic activity.
Pharmacokinets of Trimipramine
Absorption: Trimipramine is rapidly absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form
Metabolism: Trimipramine is metabolised in the liver.
Excretion: Drug is excreted mainly through urine. Some is excreted through faeces also.
Onset of Action for Trimipramine
3 weeks
Duration of Action for Trimipramine
Up to 6 weeks
Half Life of Trimipramine
24 hours
Side Effects of Trimipramine
1. Drowsiness
2. Dizziness
3. Nausea
4. Vomiting
5. Blurred vision
6. Difficulty in micturition
7. Tachycardia
8. Hypotension
9. Arrhythmia
10. Dryness of mouth
11. Constipation
12. Confusion
13. Headache
14. Sedation
15. Agranulocytosis
16. Urticaria
17. Rash
18. Jaundice
19. Anorexia
20. Impotence
21. Loss of libido
22. Galactorrhea
23. Gynecomastia

Contra-indications of Trimipramine
1. Hypersensitivity to Trimipramine
2. Myocardial infarction
Special Precautions while taking Trimipramine
1. Renal impairment
2. Hepatic impairment
3. Cardiac arrhythmia
4. Myocardial infarction
5. Tachycardia
6. Heart failure
7. Strokes
8. Angle closure glaucoma
9. History of urine retention
10. Increased intraocular pressure
11. Hyperthyroidism
12. Alcoholics
13. Patient on MAOI therapy (Discontinue the MAO inhibitor at least 2 weeks before Trimipramine is started),
14. Slowly withdraw the drug with caution
15. Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: Contraindicated
Indications for Trimipramine
1. Depression
Interactions for Trimipramine
Anticholinergics: Enhanced effect of anticholinergics may occur.
Barbiturates: Serum level of imipramine decreased; additive respiratory depressant effect.
Clonidine: Hypertensive crisis.
Dicoumarol: Increase in anticoagulation effects.
Disulfiram: Acute organic brain syndrome.
Fluoxetine & Haloperidol: Potentiate action of Trimipramine.
Levodopa: Its bioavailability is reduced, hypertensive episodes.
MAOIs, Furazolidone: Seizures, sweating, coma, hyperexcitablilty, hyperthermia, tachycardia, mydriasis, confusion, DIC. (Disseminated Intravascular Coagulation) and death.
Oral Contraceptives and Phenothiazines: Increase plasma levels of Trimipramine.
Smoking: Increases metabolic bio-transformation.
Alcohol: Sedative effect of alcohol potentiated.
Typical Dosage for Trimipramine
Adult: 25 mg 3 times a day dose can be gradually increased up to 200 mg / day.
Maintenance dose: 50 - 150 mg / day
Maximum daily dose: 300 mg

Children: Not recommended
Schedule of Trimipramine
H
Storage Requirements for Trimipramine
Store in a cool place in a tightly closed container. Keep out of the reach of children
Effects of Missed Dosage of Trimipramine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Trimipramine
Give supportive measures and treatment. Remove the drug from the body by inducing emesis and gastric lavage. Activated charcoal can be given to reduce the absorption of the drug. Physostigmine can be given to reverse the CNS side effect of overdose. Seizure can be treated with Diazepam or Phenytoin, arrhythmia with Lidocaine, and acidosis with Sodium bicarbonate

Home Delivery for Trimipramine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including trimipramine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for trimipramine and other medicines and health products. Home delivery services for trimipramine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take trimipramine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for trimipramine before they complete the sale. You can get this information while placing the order for trimipramine with the pharmacy.

Trimipramine is a generic medicine name and there are several brands available for it. Some of the brands for trimipramine might be better known than trimipramine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have trimipramine in stock, you can ask for one of the branded alternatives for trimipramine.