Desipramine Pharmacology

Desipramine

About Desipramine

Tricyclic Antidepressant (Secondary Amine) , Dibenzazepine derivative, Antidepressant.

Mechanism of Action of Desipramine

Desipramine acts by inhibiting the re-uptake of Noradrenaline and Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitters in the synaptic cleft and produces antidepressant effect. Desipramine more selectively inhibits the reuptake of Noradrenaline than Serotonin. It has less anticholinergic and hypotensive activity than its parent compound Imipramine.

Pharmacokinets of Desipramine

Absorption: It is rapidly absorbed after oral administration. Distribution: Drug is distributed mainly in protein bound form. Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted mainly in urine

Onset of Action for Desipramine

N/A

Duration of Action for Desipramine

N/A

Half Life of Desipramine

14 - 28 days

Side Effects of Desipramine

1. Dryness of mouth
2. Constipation
3. Sedation
4. Tachycardia
5. Difficulty in micturition
6. Urticaria
7. Rash
8. Dizziness
9. Lethargy
10. Headache
11. Feeling of tiredness
12. Tremor
13. Photosensitivity
14. Hypotension
15. Anorexia

Contra-indications of Desipramine

1.Hypersensitivity to Desipramine
2.Patient on MAOI therapy
3.Myocardial infarction

Special Precautions while taking Desipramine

1.Seizure disorders
2.Urine retention
3.Cardiovascular disease
4.Thyroid disease
5.Glaucoma

Pregnancy Related Information

N/A

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindiacted

Children Related Information

Use with caution
Below 12 years:Contraindiacted

Indications for Desipramine

Depression

Interactions for Desipramine

N/A

Typical Dosage for Desipramine

100-200mg /day in divided doses if needed dose can be increased to 300mg/day
Old age: 25 - 100mg / day. Maximum dose: 150mg/day

Schedule of Desipramine

N/A

Storage Requirements for Desipramine

Store at 15 - 30 degree C. Keep out of the reach of children

Effects of Missed Dosage of Desipramine

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose. Continue the regular schedule.

Effects of Overdose of Desipramine

Give supportive measures and treatment.

Home Delivery for Desipramine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including desipramine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for desipramine and other medicines and health products. Home delivery services for desipramine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take desipramine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for desipramine before they complete the sale. You can get this information while placing the order for desipramine with the pharmacy.

Desipramine is a generic medicine name and there are several brands available for it. Some of the brands for desipramine might be better known than desipramine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have desipramine in stock, you can ask for one of the branded alternatives for desipramine.