Mianserin Pharmacology


About Mianserin
Tetracyclic antidepressant, Antidepressant, anxiolytic, hypnotic, antiemetic, orexigenic.
Mechanism of Action of Mianserin
Mianserin blocks the presynaptic alpha2 adrenergic receptors and increases the turnover of Noradrenaline in the CNS .It also blocks the serotonin receptors and also increases Serotonin concentration. The increase in concentration of neurotransmitters in the CNS produces antidepressant effect. Mianserin also possess antihistamine activity.
Pharmacokinets of Mianserin
Onset of Action for Mianserin
Duration of Action for Mianserin
Half Life of Mianserin
4 - 60 hours
Side Effects of Mianserin
4.Blurred vision
Contra-indications of Mianserin
Hypersensitivity to Mianserin
Special Precautions while taking Mianserin
1.Renal impairment
2.Hepatic impairment
5.Narrow angle glaucoma
9.Prostate hypertrophy
10 Jaundice
11.Slowly withdraw the drug with caution
12.Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment

Pregnancy Related Information
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
NEONATES: contraindicated.
Indications for Mianserin
Interactions for Mianserin
Alcohol: Additive CNS depression & hence alcohol to be avoided during treatment.
MAOIs: Mianserin should not be administered concomitantly with or within 2 weeks of cessation of therapy with MAOIs.
Anxiolytics and Hypnotics: Enhanced effect.
Antiepileptics: Antagonism (convulsive threshold lowered); reduced antidepressant effect (reduced plasma-mianserin concentration).
Typical Dosage for Mianserin
Initial dose: 30 mg / day taken at night. Dose can be gradually increases to 90 mg / day
Maintenance dose: 30 - 90 mg / day as single dose at night or in 3 divided dose.
Schedule of Mianserin
Storage Requirements for Mianserin
Store in a cool dry place. Protect from direct light and heat. Keep out of the reach of children
Effects of Missed Dosage of Mianserin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Mianserin
Give supportive measures and symptomatic treatment.

Home Delivery for Mianserin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mianserin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mianserin and other medicines and health products. Home delivery services for mianserin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mianserin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mianserin before they complete the sale. You can get this information while placing the order for mianserin with the pharmacy.

Mianserin is a generic medicine name and there are several brands available for it. Some of the brands for mianserin might be better known than mianserin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mianserin in stock, you can ask for one of the branded alternatives for mianserin.