Moclobemide Pharmacology


About Moclobemide
Reversible Monoamine oxidase (MAO-A) inhibitors, Antidepressant.
Mechanism of Action of Moclobemide
Moclobemide is a reversible inhibitor of Monoamine oxidase enzyme. It selectively inhibits MAO-A than MAO-B.It decreases deamination of Serotonin, Noradrenaline and Dopamine. This will result an increase in concentration of neurotransmitters and produces antidepressant activity
Pharmacokinets of Moclobemide
Absorption: It is well absorbed after oral administration. Distribution: Only 50 % of the drug is bound to plasma protein and is extensively distributed to tissues. Metabolism: It undergoes metabolism in the liver and form inactive metabolites. Excretion: Drug and metabolites are excreted through urine.

Onset of Action for Moclobemide
2 - 4 weeks
Duration of Action for Moclobemide
12 - 18 hours
Half Life of Moclobemide
2 - 4 hours
Side Effects of Moclobemide
2.Dry mouth
6.Abdominal pain
17.Blurred vision.
Contra-indications of Moclobemide
1.Hypersensitivity to Moclobemide
2.Patient with state of severe confusion
Special Precautions while taking Moclobemide
1. Renal impairment
2. Hepatic impairment
3. Hypertension
4. Hyperthyroidism
5. Phaeochromocytoma
6. Schizophrenia
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: contraindicated
Indications for Moclobemide
Interactions for Moclobemide
Analgesics: CNS excitation or depression (hypertension or hypotension) with codeine, pethidine and possibly fentanyl, morphine and other opioid analgesics. Effects of ibuprofen and possibly other NSAIDs enhanced.
Other antidepressants: Moclobemide should not be started until at least a week after a tricyclic or related antidepressant or an SSRI or related antidepressant has been stopped (2 weeks in the case of paroxetine and sertraline, and at least 5 weeks in the case of fluoxetine), or at least a week after an MAOI has been stopped.
Dopaminergics: Hypertensive crisis with levodopa.
5HT 1 agonist: Risk of CNS toxicity (reduce dose of zolmitriptan).
Sympathomimetics: Avoid sympathomimetics like ephedrine, psuedoephedrine, and phenylpropanolamine.
Ulcer healing drugs: Cimetidine inhibits metabolism ( increases plasma-moclobemide concentration).
Tyramine rich foods: Moclobemide is likely to cause less potentiation of the presor effect of tyramine than the traditional MAOIs, but patients should be advised to avoid consuming large amounts of tyramine-rich foods (like mature cheese, yeast extracts and fermented soya bean products).
Typical Dosage for Moclobemide
Initial dose: 300 mg / day in 3 divided doses.
Dose can be gradually increases to 600 mg / day according to therapeutic response.
Schedule of Moclobemide
Storage Requirements for Moclobemide
Store at 15 - 30 degree C. Keep out of the reach of children.
Effects of Missed Dosage of Moclobemide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Moclobemide
Give supportive measures and symptomatic treatment. Drug can be removed from the body by inducing emesis and by gastric lavage. Charcoal can be given to reduce the absorption of the drug.

Home Delivery for Moclobemide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including moclobemide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for moclobemide and other medicines and health products. Home delivery services for moclobemide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take moclobemide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for moclobemide before they complete the sale. You can get this information while placing the order for moclobemide with the pharmacy.

Moclobemide is a generic medicine name and there are several brands available for it. Some of the brands for moclobemide might be better known than moclobemide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have moclobemide in stock, you can ask for one of the branded alternatives for moclobemide.