Selegiline Pharmacology


About Selegiline
A selective irreversible MAO-B inhibitor, Phenethylamine derivative, Antiparkinsonian agent, Antidepressant.
Mechanism of Action of Selegiline
Selegiline is a Monoamine oxidase enzyme inhibitor. It selectively blocks MAO-B than MAO-A at recommended dose. Selegiline inhibits the reuptake of Dopamine in to the presynaptic nerve terminal and also blocks presynaptic Dopamine receptor. This will produce Dopaminergic activity. Metabolites of Selegiline (Amphetamine and Methamphetamine) interferes the reuptake and enhances the release of neurotransmitters such as Noradrenaline, Dopamine and Serotonin and produces antidepressant effect.
Antiparkinsonian action: MAO-B (Monoamine oxidase enzyme-B) in the CNS is responsible for the metabolism of Dopamine to DOPAC (3, 4 Dihydroxy-phenyl acetic acid). Selegiline binds to MAO-B and inhibits the Dopamine degradation. Selegiline produces an increase in the concentration of Dopamine in the CNS and therefore used in the treatment of Parkinsonism.
Pharmacokinets of Selegiline
Absorption: Selegiline is rapidly absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: In the liver it is metabolised to active metabolites such as Amphetamine, Methamphetamine and N-Desmethyldeprenyl.
Excretion: It is excreted mainly through urine.
Onset of Action for Selegiline
1 hour
Duration of Action for Selegiline
1 - 3 days
Half Life of Selegiline
1 - 2 hour; under steady state condition half life is 10 hour
Side Effects of Selegiline
1. Nausea
2. Vomiting
3. Abdominal pain
4. Dizziness
5. Abdominal pain
6. Confusion
7. Hallucination
8. Dryness of mouth
9. Headache
10. Tremor
11. Chorea
12. Increased akinetic activity
13. Loss of balance
14. Insomnia
15. Arrhythmia
16. Hypotension
17. Angina pectoris
18. Weight loss
19. Rash
Contra-indications of Selegiline
1. Hypersensitivity to Selegiline
2. Patient on opiate therapy
Special Precautions while taking Selegiline
1. Arrhythmia
2. Angina pectoris
3. Hypertension
4. Peptic ulcer
5. Psychosis
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
NEONATES: Contraindicated

Indications for Selegiline
Treatment of Parkinsonism along with Levodopa.
Interactions for Selegiline
Meperidine: Contraindicated for use with meperidine since reports of fatal interactions related to its MAO inhibiting activity.
Analgesics: Hyperpyrexia and CNS toxicity with pethidine.
Antidepressants: Hypertension & CNS excitation with fluoxetine.
Typical Dosage for Selegiline
10 mg / day in 2 divided doses ;( 5 mg at breakfast and 5 mg at lunch)
Schedule of Selegiline
Storage Requirements for Selegiline
Store at room temperature in a tightly closed container. Protect from heat, light and moisture. Keep out of the reach of children
Effects of Missed Dosage of Selegiline
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Selegiline
Give supportive measures and symptomatic treatment. Drug can be removed from the body by inducing emesis or gastric lavage. To treat seizure Diazepam can be given to the patient.

Home Delivery for Selegiline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including selegiline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for selegiline and other medicines and health products. Home delivery services for selegiline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take selegiline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for selegiline before they complete the sale. You can get this information while placing the order for selegiline with the pharmacy.

Selegiline is a generic medicine name and there are several brands available for it. Some of the brands for selegiline might be better known than selegiline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have selegiline in stock, you can ask for one of the branded alternatives for selegiline.