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- Pharmacology For Escitalopram + Clonazepam
Escitalopram + Clonazepam Pharmacology
Escitalopram + Clonazepam
About Escitalopram + ClonazepamN/AMechanism of Action of Escitalopram + ClonazepamN/APharmacokinets of Escitalopram + ClonazepamN/AOnset of Action for Escitalopram + ClonazepamN/ADuration of Action for Escitalopram + ClonazepamN/AHalf Life of Escitalopram + ClonazepamN/ASide Effects of Escitalopram + ClonazepamN/AContra-indications of Escitalopram + ClonazepamN/ASpecial Precautions while taking Escitalopram + ClonazepamN/APregnancy Related InformationContraindicated. Since Escitalopram and Clonazepam are contraindicated during pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated. Since Escitalopram and Clonazepam are contraindicated during breast feeding.Children Related InformationN/AIndications for Escitalopram + Clonazepam1.Deparession
2.Panic disorder
Interactions for Escitalopram + ClonazepamN/ATypical Dosage for Escitalopram + Clonazepam1 tablet / daySchedule of Escitalopram + ClonazepamN/AStorage Requirements for Escitalopram + ClonazepamN/AEffects of Missed Dosage of Escitalopram + ClonazepamN/AEffects of Overdose of Escitalopram + ClonazepamN/AEscitalopram
About EscitalopramSelective Serotonin Reuptake Inhibitor (SSRI), Antidepressant.Mechanism of Action of EscitalopramEscitalopram is the S enantiomer of racemic Citalopram. It is 100 times more potent than R-enantiomer. Escitalopram blocks the re-uptake of neurotransmitter Serotonin from the synapse to the presynaptic nerve terminal in the CNS. This potentiates the action of Serotonin (5HT) and it is useful in the treatment of depression.Pharmacokinets of EscitalopramAbsorption: Escitalopram is well absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: Escitalopram undergoes metabolism in the liver and the metabolites are not as active as Escitalopram. Excretion: It is excreted mainly through urine.Onset of Action for Escitalopram1 weekDuration of Action for EscitalopramN/AHalf Life of Escitalopram27 - 32 hoursSide Effects of Escitalopram1.Nausea
2.Diarrhoea
3.Insomnia
4.Somnolence
5.Dry mouth
6.Fatigue
7.Increased sweating
8.Tremor
9.Dizziness
10.Agitation
11.Dyspepsia
12.Anorexia
13.Abdominal pain
14.Dysmenorrhea
15.Amenorrhea
16.Ejaculation disorder
17.Impotence
18.Polyuria
19.Upper respiratory tract infection
20.Fever
21.Myalgia
22.Arthralgia.Contra-indications of Escitalopram1. Hypersensitivity to Escitalopram or Citalopram
2. Patient on MAOI (Monoamine oxidase inhibitor) therapy.Special Precautions while taking Escitalopram1. Hepatic impairment
2. Renal impairment
3. Myocardial infarction
4. Cardiac failure
5. Epilepsy
6. Mania
7. Alcoholics
8. Patient on MAOI therapy (Discontinue the MAO inhibitor at least 2 weeks before Escitalopram is started)
9. Use cautiously in patient at risk for suicide
10. Use caution while driving vehicle, operating machine and activities requiring mental alertness or judgment
11. Withdraw the drug gradually with caution
Pregnancy Related InformationContraindicated
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated
Children Related InformationContraindicated
NEONATES: contraindicated
Indications for EscitalopramDepression.Interactions for EscitalopramN/ATypical Dosage for EscitalopramAdult: Initial dose: 10 mg / day, dose can be increased to 20 mg / day if sufficient response does not occur after a minimum of 1 week.Schedule of EscitalopramHStorage Requirements for EscitalopramStore at 15 - 30 degree C. Keep out of the reach of children. Protect from heat and light.Effects of Missed Dosage of EscitalopramTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the doseEffects of Overdose of EscitalopramGive supportive measures and treatment. Drug can be removed from the body by gastric lavage. Absorption of the drug can be reduced by the administration of Activated charcoal.Clonazepam
About ClonazepamBenzodiazepine derivative, Anticonvulsant, antipanic, muscle relaxant.Mechanism of Action of ClonazepamClonazepam binds to the BZD receptor in the CNS. The binding will facilitate GABA mediated chloride channel opening and produce hyperpolarisation. This will result in an increase in the concentration of the inhibitory neurotransmitter GABA and decreases firing rate of neuron. This in turn alters normal functions of the body. Clonazepam also blocks Pentylenetetrazol which is responsible for seizure production and therefore Clonazepam is useful in the treatment of epilepsy.Pharmacokinets of ClonazepamAbsorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Most metabolites are excreted in urineOnset of Action for Clonazepam20 - 60 minuteDuration of Action for Clonazepam6 - 12 hourHalf Life of Clonazepam18 - 40 hourSide Effects of Clonazepam1.Sedation
2.Dullness
3.Ataxia
4.Drowsiness
5.Behavioural changes
6.Amnesia
7.Lethargy
8.Nystagmus
9.Salivary secretion
10 Constipation
11.Gastritis
12.Enuresis
13.Dysuria
14.Somnolence
15.AnorexiaContra-indications of Clonazepam1.Hypersensitivity to Benzodiazepines
2.Acute narrow angle glaucomaSpecial Precautions while taking Clonazepam1.Renal impairment
2.Hepatic impairment
3.Pulmonary insufficiency
4.Mixed type seizure
5.Porphyria
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES-contraindicated
Indications for Clonazepam1. Anticonvulsant in generalised tonic-clonic, Myoclonic, Status epilepticus and Absence seizures
2. Adjunct treatment in Schizophrenia
3. Neuralgia
4. severe anxietyInteractions for ClonazepamN/ATypical Dosage for ClonazepamAdult:
Anticonvulsant: Initial dose: 0.5 mg three times a day. The dose can be gradually increased by 0.5 - 1 mg up to 20 mg / day. Maintenance dose: 4 - 8 mg / day in 3- 4 divided doses
Adjunct treatment in Schizophrenia: 0.5 - 2 mg at bed time
Neuralgia: 2 - 4 mg / day
Children:
Anticonvulsant: Initial dose10 - 30 mcg / kg / day in 3 divided dose. The dose can be gradually increased up to 200 mcg / day.
Schedule of ClonazepamH DRUGStorage Requirements for ClonazepamThe drug should be kept at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children.Effects of Missed Dosage of ClonazepamTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed doseEffects of Overdose of ClonazepamGive supportive measures and symptomatic treatment. Gastric lavage has to be done. Flumazenil can be given as antagonist. Hypotension can be treated with vasopressors.Home Delivery for Escitalopram + Clonazepam in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including escitalopram + clonazepam.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for escitalopram + clonazepam and other medicines and health products. Home delivery services for escitalopram + clonazepam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take escitalopram + clonazepam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for escitalopram + clonazepam before they complete the sale. You can get this information while placing the order for escitalopram + clonazepam with the pharmacy.
Escitalopram + Clonazepam is a generic medicine name and there are several brands available for it. Some of the brands for escitalopram + clonazepam might be better known than escitalopram + clonazepam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have escitalopram + clonazepam in stock, you can ask for one of the branded alternatives for escitalopram + clonazepam.
