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- Pharmacology For Olanzapine + Fluoxetine
Olanzapine + Fluoxetine Pharmacology
Olanzapine + Fluoxetine
About Olanzapine + FluoxetineN/AMechanism of Action of Olanzapine + FluoxetineN/APharmacokinets of Olanzapine + FluoxetineN/AOnset of Action for Olanzapine + FluoxetineN/ADuration of Action for Olanzapine + FluoxetineN/AHalf Life of Olanzapine + FluoxetineN/ASide Effects of Olanzapine + FluoxetineN/AContra-indications of Olanzapine + FluoxetineN/ASpecial Precautions while taking Olanzapine + FluoxetineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Olanzapine + FluoxetineN/AInteractions for Olanzapine + FluoxetineN/ATypical Dosage for Olanzapine + FluoxetineN/ASchedule of Olanzapine + FluoxetineN/AStorage Requirements for Olanzapine + FluoxetineN/AEffects of Missed Dosage of Olanzapine + FluoxetineN/AEffects of Overdose of Olanzapine + FluoxetineN/AOlanzapine
About OlanzapineSecond-Generation Antipsychotic, thienobenzodiazepine derivative, Atypical antipsychotic.Mechanism of Action of OlanzapineOlanzapine is a selective monoaminergic antagonist. It is a potent inhibitor of Serotonin (5HT2receptor) and Dopamine receptors (D1, D2, D3&D4). It has also antimuscarinic, alpha 1 adrenergic blocking and antihistamine activity.Pharmacokinets of OlanzapineAbsorption: Olanzapine is well absorbed after oral administration.
Distribution: It is widely distributed in the body in highly protein bound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: It is excreted mainly in urine and also in faeces.
Onset of Action for Olanzapine1 weekDuration of Action for OlanzapineN/AHalf Life of Olanzapine21 - 54 hoursSide Effects of Olanzapine1. Hypotension
2. Dry mouth
3. Sedation
4. Nausea
5. Constipation
6. Weight gain
7. Somnolence
8. Agitation
9. Headache
10.Insomnia
11. Tardive dyskinesia
12. Dizziness
13. Increase in serum transaminases level
14. Increase in prolactin level
15. Rhinitis
16. Suicidal tendencies
17. Dysphagia
Contra-indications of Olanzapine1. Hypersensitivity to OlanzapineSpecial Precautions while taking Olanzapine1. Renal impairment
2. Hepatic impairment
3. Heart disease
4. History of seizure
5. Paralytic ileus
6. Narrow angle glaucoma
7. Prostatic hypertrophy
8. Alcoholics
9. Slowly withdraw the drug with caution
10. Use caution while involving in any hazardous task
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Olanzapine1. PsychosesInteractions for OlanzapineN/ATypical Dosage for OlanzapineAdult:
Dose: 5- 10 mg / day. If sufficient response do not occur dose can be gradually increased by 5 mg every week to 20 mg / day
Schedule of OlanzapineHStorage Requirements for OlanzapineStore at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of OlanzapineTake the missed dose as soon as noticed. If it is the time for next dose then take that dose and skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OlanzapineGive supportive measures and symptomatic treatment. Gastric lavage can be done to remove the drug from the body. Absorption of the drug can be reduced by administration of activated charcoal.Fluoxetine
About FluoxetineSelective Serotonin Reuptake Inhibitor, Antidepressant.Mechanism of Action of FluoxetineFluoxetine preferentially inhibits the re-uptake of Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitter Serotonin in the synaptic cleft and produces antidepressant effect. Fluoxetine has only less affinity towards Dopaminergic, Cholinergic and Adrenergic receptors.Pharmacokinets of FluoxetineAbsorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body in protein bound form. Metabolism: Fluoxetine is extensively metabolised in the liver to Norfluoxetine. Excretion: Excreted mainly through urine.Onset of Action for Fluoxetine2- 4 weeksDuration of Action for FluoxetineUp to 6 weeksHalf Life of Fluoxetine2 - 9 daysSide Effects of Fluoxetine1.Drowsiness
2.Headache
3.Nervousness
4.Insomnia
5.Anxiety
6.Dizziness
7.Tremor
8.Fatigue
9.Asthenia
10.Anorexia
11.Nausea
12.Diarrhoea
13.Dry mouth
14.Sweating
15.Pruritis
16.Rash.Contra-indications of FluoxetineHypersensitivity to FluoxetineSpecial Precautions while taking Fluoxetine1.Hepatic disease
2.Renal disease
3.Cardiovascular disease
4.Epilepsy
5 Diabetes mellitus
6.Patient on MAOI therapy (Discontinue the MAO inhibitor at least 2 weeks before Fluoxetine is started)
7.Alcoholics
8.Patient at high risk of suicide
9.Slowly withdraw the drug with caution
10.Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicated.Children Related InformationContraindicated.
NEONATES: contraindicated
Indications for Fluoxetine1.Depression
2.Panic disorder
3.Obsessive compulsive disorder
4.Obesity
5.Bulimia nervosa.Interactions for FluoxetineMAOIs: Serious life threatening reactions. At least 14 days should elapse after MAOIs withdrawal and initiation of fluoxentine. At least 5 weeks should elapse after fluoxentine withdrawal and initiation of the therapy with MAOIs.
Diazepam: Half-life of diazepam prolonged.
Haloperidol: Chances of severe extrapyramidal reactions.
Lithium: Serum lithium levels increased leading to toxicity.
TCAs: Efiicacy and toxic effects of TCAs enhanced.
Warfarin, Digoxin: Since tightly bound to plasma proteins, concomitant use of other drugs bound to plama proteins may cause shift in plasma concentration resulting in adverse effects.Typical Dosage for FluoxetineAdult:
Depression, Panic disorder: Initial dose: 20 mg in the morning for 1 month. Dose can be increased to 40 mg / day in two divided doses (20 mg at morning and 20 mg at noon) if sufficient response does not occur
Maximum dose: 80 mg / day
Obsessive compulsive disorder, Obesity: 20 - 60 mg / day
Bulimia nervosa: 60 - 80 mg / day
Schedule of FluoxetineHStorage Requirements for FluoxetineStore at 15 - 25 degree C. Keep out of the reach of children.Effects of Missed Dosage of FluoxetineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of FluoxetineGive supportive measures and symptomatic treatment. Gastric lavage can be done to eliminate the drug from the body. Charcoal can be given to reduce the absorption of the drug.Home Delivery for Olanzapine + Fluoxetine in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for olanzapine + fluoxetine and other medicines and health products. Home delivery services for olanzapine + fluoxetine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take olanzapine + fluoxetine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for olanzapine + fluoxetine before they complete the sale. You can get this information while placing the order for olanzapine + fluoxetine with the pharmacy.
Olanzapine + Fluoxetine is a generic medicine name and there are several brands available for it. Some of the brands for olanzapine + fluoxetine might be better known than olanzapine + fluoxetine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have olanzapine + fluoxetine in stock, you can ask for one of the branded alternatives for olanzapine + fluoxetine.
