Trazodone Pharmacology


About Trazodone
Serotonin Reuptake Inhibitor/Antagonist, a triazolopyridine derivative, Antidepressant.
Mechanism of Action of Trazodone
Trazodone has prominent 5HT2 antagonistic action and alpha adrenergic blocking action. It selectively but less efficiently blocks the re-uptake of neurotransmitter Serotonin from the synapse in to the presynaptic nerve terminal in the CNS. Trazodone potentiates the neurotransmitter activity and produces antidepressant action. It also produces sedation.
Pharmacokinets of Trazodone
Absorption: Trazodone is well absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: It undergoes metabolism in the liver.
Excretion: Excreted mainly in urine and rest in faeces.
Onset of Action for Trazodone
3 - 4 days
Duration of Action for Trazodone
Upto 6 weeks
Half Life of Trazodone
6 hours
Side Effects of Trazodone
1. Drowsiness
2. Dizziness
3. Nervousness
4. Dry mouth
5. Constipation
6. Blurred vision
7. Nausea
8. Vomiting
9. Fatigue
10. Headache
11. Insomnia
12. Rash
13. Prurits
14. Priapism
15. Confusion
16. Tremor
Contra-indications of Trazodone
1. Hypersensitivity to Trazodone
Special Precautions while taking Trazodone
1. Hepatic impairment
2. Renal impairment
3. Myocardial infarction
4. Hypertension
5. Epilepsy
6. Alcoholics
7. Use cautiously in patient at risk for suicide
8. Use caution while driving vehicle, operating machine and activities requiring mental alertness or judgment
9. Slowly withdraw the drug with caution
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
NEONATES: Contraindicated
Indications for Trazodone
1. Depression.
Interactions for Trazodone
Alcohol, Barbiturates and other CNS depressants : Trazodone enhances the CNS depressant effects of these drugs.
Digoxin : Serum levels of digoxin increased.
MAOIs : Exercise caution when coadministering trazodone.
Phenytion : Increased serum levels of phenytoin.
Warfarin: The hypoprothrombinemic effect of warfarin may be decreased.
Typical Dosage for Trazodone
Initial dose: 150mg / day in 2- 3 divided doses with food. If sufficient response do not occur dose can be increased by 50 mg every 3 - 4 days intervals up to 400 mg / day.
Maximum dose: 600 mg / day.
Schedule of Trazodone
Storage Requirements for Trazodone
Store at 15 - 30 degree C. Keep out of the reach of children. Protect from direct light and heat.
Effects of Missed Dosage of Trazodone
Take the missed dose as soon as noticed. If it is the time for next dose then take only that dose and skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Trazodone
Give supportive measures and symptomatic treatment. Drug can be removed from the body by inducing emesis and by gastric lavage. Activated charcoal can be given to reduce the absorption of the drug. Forced diuresis can also be done to eliminate the drug from the body.

Home Delivery for Trazodone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including trazodone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for trazodone and other medicines and health products. Home delivery services for trazodone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take trazodone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for trazodone before they complete the sale. You can get this information while placing the order for trazodone with the pharmacy.

Trazodone is a generic medicine name and there are several brands available for it. Some of the brands for trazodone might be better known than trazodone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have trazodone in stock, you can ask for one of the branded alternatives for trazodone.