Reboxetine Pharmacology


About Reboxetine
A norepinephrine reuptake inhibitor (NRI), Morpholine derivative, Antidepressant.
Mechanism of Action of Reboxetine
Reboxetine blocks the re-uptake of neurotransmitter Noradrenaline from the synapse in to the presynaptic nerve terminal in the CNS. This will prolong the action of Noradrenaline and lighten the mood.
Pharmacokinets of Reboxetine
Absorption: Reboxetine is well absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It undergoes metabolism in the liver. Excretion: Drug is excreted mainly through urine.
Onset of Action for Reboxetine
2- 3 weeks
Duration of Action for Reboxetine
Half Life of Reboxetine
13 hours
Side Effects of Reboxetine
1. Insomnia
2. Dizziness
3. Dry mouth
4. Constipation
5. Increased sweating
6. Hypotension
7. Tachycardia
8. Impotence
9. Vertigo
10. Paresthesia
11. Dysuria
12. Urinary retention
Contra-indications of Reboxetine
1. Hypersensitivity to Reboxetine
Special Precautions while taking Reboxetine
1.Hepatic impairment
2.Renal impairment
3.Cardiovascular diseases
4.Urinary retention
6.Bipolar disorders
7.Prostatic hypertrophy
9.Use caution while driving vehicle, operating machine and activities requiring mental alertness or judgment
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: Contraindicated
Indications for Reboxetine
Interactions for Reboxetine
Anti-arrhythmics: Use with caution.
Anti-bacterials: Avoid use with macrolides and linezolid.
Other anti-depressants: Risk of increased toxicity with MAOIs.
Antifungals: Caution advised in use with imidazole and triazole.
Antimalarials: Avoid concomitant use with artemether.
Diuretics: Possible increased risk of hypokalaemia in concomitamt use with loop diuretics or thiazides.
Ergotamine: Possible increased blood pressure.
Sibutramine: Increased risk of CNS toxicity; avoid concomitant use.
Typical Dosage for Reboxetine
Initial dose: 8mg / day in 2 divided doses; dose can be increased to 10 mg after 3 - 4 week if sufficient response does not occur.
Maximum dose: 12 mg / day
Schedule of Reboxetine
Storage Requirements for Reboxetine
Store at 15 - 30 degree C. Keep out of the reach of children. Protect from direct light and heat.
Effects of Missed Dosage of Reboxetine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Reboxetine
Give supportive measures and symptomatic treatment.

Home Delivery for Reboxetine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including reboxetine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for reboxetine and other medicines and health products. Home delivery services for reboxetine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take reboxetine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for reboxetine before they complete the sale. You can get this information while placing the order for reboxetine with the pharmacy.

Reboxetine is a generic medicine name and there are several brands available for it. Some of the brands for reboxetine might be better known than reboxetine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have reboxetine in stock, you can ask for one of the branded alternatives for reboxetine.