Adenosine Pharmacology


About Adenosine
Naturally occuring purine Nucleoside,Class IV Antiarrhythmic Agent, Diagnostic Agent.
Mechanism of Action of Adenosine
Adenosine is a nucleoside; administered as freebase or ATP. It exerts it`s pharmacological action by activating acetyl choline sensitive K+ channels and causes membrane hyperpolarisation through interaction with A1 type of G protein coupled adenosine receptors on SA node and thus causes depression, prolongation of effective refractory period and slowing of conduction in AV node, shortening of action potential and reduced excitability in atrium. It also indirectly reduces Ca2+ current in AV node; depression of reentrant circuit through AV node is responsible for its action against Paroxysmal supra ventricular tachycardia. Adrenergically induced after depolarization; in ventricles is also suppressed. It also causes transient coronary dilatation and it is a local mediator involved in auto regulation of coronary flow in response to ischaemia.
Pharmacokinets of Adenosine
Absorption: It should be administered parenterally as rapid I.V. injection. Distribution: Distributed mostly in to vascular endothelial cells and erythrocytes. Metabolism: Metabolized within the tissues in to inosine monophosphate and adenosine monophosphate and finally in to xanthine
Onset of Action for Adenosine
Duration of Action for Adenosine
Half Life of Adenosine
Below 10 seconds
Side Effects of Adenosine
3.Facial flushing
7.Metallic taste
9.Chest pain
10.Shortness of breath
12.Tightness in throat
13.Blurred vision
14.Back pain
16.Light- headedness
17.Tingling in fingers
18.Neck pain
19.Metallic taste
20.Burning sensation
Contra-indications of Adenosine
1.Hypersensitivity to the drug
2.Second or third degree heart block
3.Sick sinus syndrome
4.Bronchial asthma
5.Atrial fibrillation
6.Atrial flutter
Special Precautions while taking Adenosine
2.Patient with an accessory bypass tract or in atrial flutter or atrial fibrillation may develop increased conduction down the anomalous pathway.
3.Patients in whom significant heart bock develops after a dose of adenosine should not receive additional doses.
4.Along with Dipyridamole.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Adenosine
1.Paroxysmal supra ventricular tachycardia
2.Diagnosis of re-entrant atrial and ventricular tachycardia.
Interactions for Adenosine
Dipyridamole: Potentiate the Adenosine effects
Methyl xanthines(Caffeine, Theophylline): Antagonises adenosine effects
Carbamazepine: Concomitant use of Carbamazepine with Adenosine increases the heart block
Typical Dosage for Adenosine
Starts with 3mg I. V.; by rapid bolus injection over 1 to 2 seconds. Then 6mg may be given after 1 to 2 minutes if required. Further increase in dose up to 12mg and repeat the same dose if required.
Starts with 50 to 100mcg/kg. Increase if required by increments of same dose at 1 to 2 minutes intervals until therapeutic goal is achieved.
Maximum child dose: 300mcg/kg.
Schedule of Adenosine
Storage Requirements for Adenosine
Store at controlled room temperature at a range of 15 to 30 degree C. Do not refrigerate and discard unused portion.
Effects of Missed Dosage of Adenosine
Effects of Overdose of Adenosine
Adverse effects of overdose are self limiting, because half life is lower than 10 seconds. Treatment is supportive and symptomatic

Home Delivery for Adenosine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including adenosine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for adenosine and other medicines and health products. Home delivery services for adenosine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take adenosine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for adenosine before they complete the sale. You can get this information while placing the order for adenosine with the pharmacy.

Adenosine is a generic medicine name and there are several brands available for it. Some of the brands for adenosine might be better known than adenosine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have adenosine in stock, you can ask for one of the branded alternatives for adenosine.