Fluphenazine Pharmacology

Fluphenazine

About Fluphenazine
First-Generation Antipsychotic, phenothiazine:piperazine derivative, Typical Antipsychotic.
Mechanism of Action of Fluphenazine
Fluphenazine binds to the dopamine receptor (D1, D2, D3 &D4).It exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. Peripherally and centrally it acts as a competitive Dopamine antagonist. Fluphenazine also produces alpha adrenergic blocking activity and anticholinergic activity. It also produces weak H1 antihistaminic activity and anti serotonin activity

Pharmacokinets of Fluphenazine
Absorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in plasma protein bound form. Metabolism: It is metabolised in the liver .Excretion: It is excreted mainly through urine. Small amount of drug is excreted through faeces and breast milk.
Onset of Action for Fluphenazine
60 minutes
Duration of Action for Fluphenazine
6 - 8 hour
Half Life of Fluphenazine
14 - 24 hour
Side Effects of Fluphenazine
1.Tardive dyskinesia
2.Extrapyramidal reactions
3.Drowsiness
4.Sedation
5.Dizziness
6.Hypotension
7.Dry mouth
8.Constipation
9.Blurred vision
10.Aplastic anaemia
11.Thrombocytopenia
12.Insomnia
13.Nausea
14.Vomiting
15.Gastritis


Contra-indications of Fluphenazine
1.Hypersensitivity to Fluphenazine and other Phenothiazines
2.Comatose
3.Blood dyscrasias
4.Patient taking antidepressants
5.Liver damage
Special Precautions while taking Fluphenazine
1.Renal impairment
2.Hepatic impairment
3.Cardiovascular disease
4.Pheochromocytoma
5.Hypocalcaemia
6.Epilepsy
7.Cholestatic jaundice
8.Patient exposed to extreme heat or cold or phosphorus insecticides,
9.Ceribrovascular disorder
10.Patient on ECT
11.Reaction to Insulin
12.Prostatic hyperplasia
13.Glaucoma
14.Peptic ulcer
15.Slowly withdraw the drug with caution


Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Below 12 years: Contraindicated
Indications for Fluphenazine
1.Psychoses
2.Schizophrenia
3.Mania
4.Severe anxiety
5.Behavioural disturbances
Interactions for Fluphenazine
Alcohol : CNS depression, extrapyramidal reactions.
Aluminium Salts : Decrease efficacy. Antacids should be given 1 hour before or 2 hours after fluphenazine.
Anticholinergics : Decrease efficacy and increase the anticholinergic side effects of fluphenazine.
Barbiturates : Decreases efficacy.
Barbiturate anaesthetics : Increase frequency and severity of neuromuscular excitation and hypotension.
Bromocriptine : Efficacy decreased by fluphenazine.
Charcoal : Prevents absorption of fluphenazine.
Epinephrine, Norepinephrine : Pressor effect decreased, peripheral vasoconstrictive effect antagonised.
Lithium : Disorientation, unconsciousness and extrapyramidal symptoms.
Meperidine : Excessive sedation and hypotension.
TCAs : Serum concentration increased by fluphenazine.
Valproic acid : Efficacy potentiated.
Propranolol : Increased plasma levels of both drugs.
MAOIs : Additive orthostatic hypotensive effect.
Laboratory Tests : Pregnancy tests : False positive results.
Plasma bound iodine (PBI) : Increase in PBI occurs.


Typical Dosage for Fluphenazine
Adult:
Psychoses, Schizophrenia, Mania
0.5 - 10 mg / day in 3 - 4 divided doses. If needed dose can be increased up to 20 mg / day
Maintenance dose: 1 - 5 mg / day
Behavioral disturbances, Adjunct to anxiety treatment: 2mg / day in 2 divided doses. If required the dose can be increased to 4 mg / day
Schedule of Fluphenazine
H
Storage Requirements for Fluphenazine
The drug should be kept at 25 degree C in a tightly closed container. Protect from heat and light.
Effects of Missed Dosage of Fluphenazine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Fluphenazine
Give supportive measures and treatment. Gastric lavage has to be done followed by charcoal administration. Hypotension can be treated with IV fluids, seizure with Diazepam or Barbiturates and extra pyramidal reactions with Benztropine.

Home Delivery for Fluphenazine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fluphenazine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fluphenazine and other medicines and health products. Home delivery services for fluphenazine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take fluphenazine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fluphenazine before they complete the sale. You can get this information while placing the order for fluphenazine with the pharmacy.

Fluphenazine is a generic medicine name and there are several brands available for it. Some of the brands for fluphenazine might be better known than fluphenazine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluphenazine in stock, you can ask for one of the branded alternatives for fluphenazine.